Accidental and iatrogenic causes of acute kidney injury

Twombley, Katherine; Baum, Michel; Gattineni, Jyothsna

doi:10.1097/mop.0b013e328343cd16

Cited by 10 publications

(2 citation statements)

References 94 publications

(94 reference statements)

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“…Although AKI is potentially reversible, it is one of the leading causes of in-hospital mortality. In spite of potential recovery from AKI, patients remain predisposed to long-term impairment or loss of kidney function (Bonventre & Yang 2011, Srisawat & Kellum 2011, Twombley et al 2011, Zarjou & Agarwal 2011, Bellomo et al 2012, Yap & Lee 2012.…”

Section: Introductionmentioning

confidence: 99%

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Linking non‐invasive parametric MRI with invasive physiological measurements (MR‐PHYSIOL): towards a hybrid and integrated approach for investigation of acute kidney injury in rats

et al. 2013

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Acute kidney injury of various origins shares a common link in the pathophysiological chain of events: imbalance between renal medullary oxygen delivery and oxygen demand. For in vivo assessment of kidney haemodynamics and oxygenation in animals, quantitative but invasive physiological methods are established. A very limited number of studies attempted to link these invasive methods with parametric Magnetic Resonance Imaging (MRI) of the kidney. Moreover, the validity of parametric MRI (pMRI) as a surrogate marker for renal tissue perfusion and renal oxygenation has not been systematically examined yet. For this reason, we set out to combine invasive techniques and non-invasive MRI in an integrated hybrid setup (MR-PHYSIOL) with the ultimate goal to calibrate, monitor and interpret parametric MR and physiological parameters by means of standardized interventions. Here we present a first report on the current status of this multi-modality approach. For this purpose, we first highlight key characteristics of renal perfusion and oxygenation. Second, concepts for in vivo characterization of renal perfusion and oxygenation are surveyed together with the capabilities of MRI for probing blood oxygenation-dependent tissue stages. Practical concerns evoked by the use of strong magnetic fields in MRI and interferences between MRI and invasive physiological probes are discussed. Technical solutions that balance the needs of in vivo physiological measurements together with the constraints dictated by small bore MR scanners are presented. An early implementation of the integrated MR-PHYSIOL approach is demonstrated including brief interventions of hypoxia and hyperoxia.

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Section: Introductionmentioning

confidence: 99%

“…In spite of potential recovery from AKI, patients remain predisposed to long‐term impairment or loss of kidney function (Bonventre & Yang , Srisawat & Kellum , Twombley et al . , Zarjou & Agarwal , Bellomo et al . , Yap & Lee ).…”

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confidence: 99%