Accessory Chromosomes of the Fusarium oxysporum Species Complex and Their Contribution to Host Niche Adaptation

Yu, Houlin; Ayhan, Dilay Hazal; Martínez‐Soto, Domingo; Cochavi, Shira Milo; Ma, Lijun

doi:10.1007/978-3-031-16503-0_16

Cited by 6 publications

(9 citation statements)

References 141 publications

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“…The fungal species complex of Fusarium oxysporum (FOSC) has been used as a model to study cross-kingdom fungal pathogenesis. Members within FOSC can cause devastating fusarium wilt diseases among economically important crops [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ] and is listed among the top five most important plant pathogens [ 8 ]. With strong host specificity, plant pathogenic F. oxysporum strains are further grouped as formae speciales [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…cubense [ 10 ]. Recently, members within FOSC have also been reported to be responsible for fusariosis, the top emerging opportunistic mycosis [ 1 , 7 , 12 ], and fusarium keratitis, one of the major causes of cornea infections in the developing world and the leading cause of blindness among fungal keratitis patients [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Comparative genomics studies on this cross-kingdom pathogen revealed that the FOSC genomes, both human and plant pathogens, are compartmentalized into two components: the core chromosomes (CCs) and accessory chromosomes (ACs). While CCs are conserved and vertically inherited to execute essential housekeeping functions, horizontally transmitted ACs are lineage- or strain-specific and are related to fungal adaptation and pathogenicity [ 1 , 7 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex

Haridas

et al. 2023

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The Fusarium oxysporum species complex (FOSC) includes both plant and human pathogens that cause devastating plant vascular wilt diseases and threaten public health. Each F. oxysporum genome comprises core chromosomes (CCs) for housekeeping functions and accessory chromosomes (ACs) that contribute to host-specific adaptation. This study inspects global transcription factor profiles (TFomes) and their potential roles in coordinating CC and AC functions to accomplish host-specific interactions. Remarkably, we found a clear positive correlation between the sizes of TFomes and the proteomes of an organism. With the acquisition of ACs, the FOSC TFomes were larger than the other fungal genomes included in this study. Among a total of 48 classified TF families, 14 families involved in transcription/translation regulations and cell cycle controls were highly conserved. Among the 30 FOSC expanded families, Zn2-C6 and Znf_C2H2 were most significantly expanded to 671 and 167 genes per family including well-characterized homologs of Ftf1 (Zn2-C6) and PacC (Znf_C2H2) that are involved in host-specific interactions. Manual curation of characterized TFs increased the TFome repertoires by 3% including a disordered protein Ren1. RNA-Seq revealed a steady pattern of expression for conserved TF families and specific activation for AC TFs. Functional characterization of these TFs could enhance our understanding of transcriptional regulation involved in FOSC cross-kingdom interactions, disentangle species-specific adaptation, and identify targets to combat diverse diseases caused by this group of fungal pathogens.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex

Haridas

et al. 2023

JoF

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“…The core genome, very similar among all the formae speciales sequenced to date and also to the related species F. graminearum and F. verticillioides, encompasses 11 chromosomes that contain genes required for basic metabolism and differentiation. The accessory genome, which spands several lineage-specific chromosomes and some parts of the core genome chromosomes, contains sophisticated genomic elements linked to pathogenicity, virulence and host specificity [5,6]. The term "accessory" relates to the fact that the genetic elements in this genome are not required for basic saprophytic growth and development.…”

Section: Introductionmentioning

confidence: 99%

The Role of the <em>Fusarium oxysporum</em> FTF2 Transcription Factor in Host Colonization and Virulence

Castillo¹,

Benito²,

Díaz-Mínguez.³

2023

Preprint

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The FTF (Fusarium Transcription Factor) gene family is composed of two members (FTF1 and FTF2) with high sequence homology. Both genes encode Zn(II)2Cys6 binuclear zinc finger transcription factors involved in the modulation of virulence in the F. oxysporum species complex (FOSC). While FTF1 is a multicopy gene exclusive of highly virulent strains of FOSC and is located in the accessory genome, FTF2 is a single copy gene, located in the core genome, and well conserved in all filamentous ascomycete fungi, except yeast. The involvement of FTF1 in the colonization of the vascular system and regulation of the expression of SIX effectors has been stablished. To address the role of FTF2 we generated and characterized null FTF2 mutants in a F. oxysporum f. sp. phaseoli weakly virulent strain and analyzed them together with the equivalent mutants formerly obtained in a highly virulent strain. The results obtained highlight a role for FTF2 as a negative regulator of the production of macroconidia and demonstrate that it is required for full virulence and positive regulation of SIX effectors. In addition, gene expression analyses provide compelling evidence that FTF2 is involved in the regulation of hydrophobins likely required for plant colonization.

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“…The core genome, very similar among all the formae speciales sequenced to date and also to the related species F. graminearum and F. verticillioides , encompasses 11 chromosomes that contain genes required for basic metabolism and differentiation. The accessory genome, which spans several lineage-specific chromosomes and some parts of the core-genome chromosomes, contains sophisticated genomic elements linked to pathogenicity, virulence, and host specificity [ 5 , 6 ]. The term “accessory” relates to the fact that the genetic elements in this genome are not required for basic saprophytic growth and development.…”

Section: Introductionmentioning

confidence: 99%

The Role of the Fusarium oxysporum FTF2 Transcription Factor in Host Colonization and Virulence in Common Bean Plants (Phaseolus vulgaris L.)

2023

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The FTF (Fusarium Transcription Factor) gene family is composed of two members (FTF1 and FTF2) with high-sequence homology that encode transcription factors involved in the modulation of virulence in the F. oxysporum species complex (FOSC). While FTF1 is a multicopy gene exclusive of highly virulent strains of FOSC and is located in the accessory genome, FTF2 is a single-copy gene, located in the core genome, and well-conserved in all filamentous ascomycete fungi, except yeast. The involvement of FTF1 in the colonization of the vascular system and regulation of the expression of SIX effectors has been stablished. To address the role of FTF2, we generated and characterized mutants defective in FTF2 in a F. oxysporum f. sp. phaseoli weakly virulent strain and analyzed them together with the equivalent mutants formerly obtained in a highly virulent strain. The results obtained highlight a role for FTF2 as a negative regulator of the production of macroconidia and demonstrate that it is required for full virulence and the positive regulation of SIX effectors. In addition, gene expression analyses provided compelling evidence that FTF2 is involved in the regulation of hydrophobins likely required for plant colonization.

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Accessory Chromosomes of the Fusarium oxysporum Species Complex and Their Contribution to Host Niche Adaptation

Cited by 6 publications

References 141 publications

Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex

Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex

The Role of the <em>Fusarium oxysporum</em> FTF2 Transcription Factor in Host Colonization and Virulence

The Role of the Fusarium oxysporum FTF2 Transcription Factor in Host Colonization and Virulence in Common Bean Plants (Phaseolus vulgaris L.)

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