Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines

Bondada, Subbarao; Wu, Ho‐Ting; Robertson, Darrell A.; Chelvarajan, R. Lakshman

doi:10.1016/s0264-410x(00)00161-4

Cited by 59 publications

(44 citation statements)

References 71 publications

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“…Similar findings were reported by Bondada et al (25) who found that purified B cells were unable to produce Abs against TNP-Ficoll, a TI-2 Ag. This is at odds with previously published data that indicate that the Ab response in athymic nude mice is essentially unchanged relative to euthymic mice (20,21), indicating that the Ab response to caps-PS can occur independent of T lymphocytes.…”

Section: Discussionsupporting

confidence: 90%

“…Garg et al (28) showed that, in contrast to in vitro culture of spleen cells, in vitro culture of lymph node cells did not respond to caps-PS, and that addition of APCs isolated from spleen cells enabled the lymph node to respond to caps-PS. It was further put forward that defects in APC function might play a critical role in the failure of neonates to respond to caps-PS (29).…”

Section: Discussionmentioning

confidence: 99%

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CD4+ T Lymphocytes Expressing CD40 Ligand Help the IgM Antibody Response to Soluble Pneumococcal Polysaccharides via an Intermediate Cell Type

Jeurissen

Billiau²,

Moens³

et al. 2006

The Journal of Immunology

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Streptococcus pneumoniae causes serious infections in children, the elderly, and immunocompromised patients. Protection against infections with S. pneumoniae is mediated through Abs against the capsular polysaccharides (caps-PS). We previously showed that the murine Ab response to caps-PS is dependent on CD40-CD40L interaction. In the present paper, we addressed the question of whether the CD40-CD40L-mediated modulation of the anti-caps-PS immune reaction is the result of a direct interaction between B lymphocytes and T lymphocytes or of an indirect interaction. SCID/SCID mice reconstituted with B lymphocytes from wild-type mice did not mount anti-caps-PS Abs. SCID/SCID mice reconstituted with B lymphocytes from wild-type mice and CD4+ T lymphocytes from wild-type mice but not CD4+ T lymphocytes from CD40L knockout mice stimulated the anti-caps-PS Ab response. This indicated that CD4+ T lymphocytes stimulated the anti-caps-PS Ab response in a CD40L-dependent manner. SCID/SCID mice reconstituted with B lymphocytes from CD40 knockout mice and CD4+ T lymphocytes from wild-type mice generated an anti-caps-PS Ab response that could be inhibited by MR1, a blocking anti-CD40L Ab. These data indicated that CD4+ T lymphocytes stimulated the anti-caps-PS Ab response in an indirect way. Finally, lethally irradiated CD40 knockout mice reconstituted with bone marrow from wild-type mice mounted an anti-caps-PS Ab response that was comparable to the Ab response in wild-type mice, revealing that the required CD40 was on hemopoietic cells. In conclusion, we provide evidence that CD4+ T lymphocytes expressing CD40L stimulate the Ab response to soluble caps-PS by interacting with CD40-expressing non-B cells.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

CD4+ T Lymphocytes Expressing CD40 Ligand Help the IgM Antibody Response to Soluble Pneumococcal Polysaccharides via an Intermediate Cell Type

Jeurissen

Billiau²,

Moens³

et al. 2006

The Journal of Immunology

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“…We recently proposed that PEG on the PEGylated liposome stimulates the immune system as one of the TI antigens, 37,38) such as bacterial polysaccharide and polyvinyl pyrrolidone. 39) Once the PEGylated proteins reach the spleen, they may bind and crosslink to anti-PEG IgM expressed on the surface of B cells, and consequently trigger the production of an anti-PEG IgM. With respect to PEGylated liposome, we showed that lipid dose for injection is one of crucial factors to determine the level of anti-PEG IgM induction; the higher the dose the smaller the anti-PEG IgM induction.…”

Section: Discussionmentioning

confidence: 86%

Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response

Shimizu

Ichihara

Yoshioka

et al. 2012

Biological & Pharmaceutical Bulletin

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“…Deficiencies in MZ B cells are also associated with elevated risk of pneumococcal infection and poor antibody responses to capsular polysaccharides 12, 13. Invasive pneumococcal disease from S. pneumoniae infection is a leading cause of mortality in people > 65 years old,14 and the efficacy of vaccines against this disease is decreased in the elderly 15. Although many studies have addressed the ageing‐related changes to the thymus, T cells and T‐cell‐dependent antibody responses, nothing was known of how ageing influenced the function of MZ B cells and their rapid induction of TI antibody responses.…”

Section: Introductionmentioning

confidence: 99%

Ageing adversely affects the migration and function of marginal zone B cells

Turner

Mabbott

2017

Immunology

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SummaryMarginal zone (MZ) B cells are positioned within the spleen to capture blood‐borne antigen and immune complexes and deliver them to follicular dendritic cells in the B‐cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, were impaired. The ability of aged MZ B cells to migrate towards the MZ chemoattractant sphingosine‐1‐phosphate was increased, suggesting that aged MZ B cells had a greater propensity to be retained within the MZ. An extrinsic impairment in aged B‐cell migration towards the MZ was demonstrated using bone marrow chimeras. The follicular shuttling of MZ B cells derived from either young or aged bone marrow was similarly reduced in aged recipient spleens, showing that ageing effects on splenic stromal cells were responsible for the impaired follicular shuttling of MZ B cells. MZ B cells rapidly mount T‐cell‐independent (TI) antibody‐responses to microbial polysaccharide antigen. In aged mice the ability to produce immunoglobulins in response to the TI type 1 antigen TNP‐LPS was impaired. These ageing‐related changes to the MZ and MZ B cells have implications for the clearance of blood‐borne pathogens. Indeed elderly people have increased susceptibility to Streptococcus pneumoniae, a TI antigen, and decreased responses to vaccination. A thorough analysis of the mechanisms that underpin the ageing‐related decline in the status of the MZ and MZ B cells will help the design of novel treatments to improve immunity in the elderly.

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Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines

Cited by 59 publications

References 71 publications

CD4+ T Lymphocytes Expressing CD40 Ligand Help the IgM Antibody Response to Soluble Pneumococcal Polysaccharides via an Intermediate Cell Type

CD4+ T Lymphocytes Expressing CD40 Ligand Help the IgM Antibody Response to Soluble Pneumococcal Polysaccharides via an Intermediate Cell Type

Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response

Ageing adversely affects the migration and function of marginal zone B cells

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