Accessible pediatric neuroimaging using a low field strength MRI scanner

Deoni, Sean; Bruchhage, Muriel; Beauchemin, Jennifer; Volpe, Alexandra; D’Sa, Viren; Huentelman, Matthew J.; Williams, Steven

doi:10.1016/j.neuroimage.2021.118273

Cited by 42 publications

(48 citation statements)

References 33 publications

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“…High-field systems offer an array of imaging technqiues and acquisition protocols that are not currently matched on the Hyperfine system. However, in some cases, for example structural neuroimaging and brain volumetric analysis, the Hyperfine system can provide complementary information 16 .…”

Section: Discussionmentioning

confidence: 99%

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Development of a mobile low-field MRI scanner

Deoni

Medeiros²,

Deoni

et al. 2022

Sci Rep

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Magnetic resonance imaging (MRI) allows important visualization of the brain and central nervous system anatomy and organization. However, unlike electroencephalography (EEG) or functional near infrared spectroscopy, which can be brought to a patient or study participant, MRI remains a hospital or center-based modality. Low magnetic field strength MRI systems, however, offer the potential to extend beyond these traditional hospital and imaging center boundaries. Here we describe the development of a modified cargo van that incorporates a removable low-field permanent magnet MRI system and demonstrate its proof-of-concept. Using phantom scans and in vivo T2-weighted neuroimaging data, we show no significant differences with respect to geometric distortion, signal-to-noise ratio, or tissue segmentation outcomes in data acquired in the mobile system compared to a similar static system in a laboratory setting. These encouraging results show, for the first time, MRI that can be performed at a participant’s home, community center, school, etc. Breaking traditional barriers of access, this mobile approach may enable imaging of patients and participants who have mobility challenges, live long distances from imaging centers, or are otherwise unable to travel to an imaging center or hospital.

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Section: Discussionmentioning

confidence: 99%

“…17 min, including pre-scan calibration and localizer scans. While the Hyperfine Swoop is currently capable of T 1 , T 2 , and T 2 -FLAIR weighted anatomical imaging, we have restricted our analysis to T 2 -weighted data as we find it provides the best image contrast and quality 16 .…”

Section: Methodsmentioning

confidence: 99%

Development of a mobile low-field MRI scanner

Deoni

Medeiros²,

Deoni

et al. 2022

Sci Rep

Self Cite

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“…One key question is how can non-invasive techniques (neuroimaging, microbiome, functional measures such as EEG, culturally appropriate developmental tools) be used in resource-limited settings to address questions around the trajectory of brain growth and development in this high-risk context? While these tools are available in limited contexts across the continent, the challenge is to take this new technology to scale in this rich, but barely explored region ( Deoni et al, 2021 ).…”

Section: Six Domains Of Distinction For Potential Of Neuroscience In ...mentioning

confidence: 99%

What is next in African neuroscience?

Donald

Maina

Patel

et al. 2022

eLife

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Working in Africa provides neuroscientists with opportunities that are not available in other continents. Populations in this region exhibit the greatest genetic diversity; they live in ecosystems with diverse flora and fauna; and they face unique stresses to brain health, including child brain health and development, due to high levels of traumatic brain injury and diseases endemic to the region. However, the neuroscience community in Africa has yet to reach its full potential. In this article we report the outcomes from a series of meetings at which the African neuroscience community came together to identify barriers and opportunities, and to discuss ways forward. This exercise resulted in the identification of six domains of distinction in African neuroscience: the diverse DNA of African populations; diverse flora, fauna and ecosystems for comparative research; child brain health and development; the impact of climate change on mental and neurological health; access to clinical populations with important conditions less prevalent in the global North; and resourcefulness in the reuse and adaption of existing technologies and resources to answer new questions. The article also outlines plans to advance the field of neuroscience in Africa in order to unlock the potential of African neuroscientists to address regional and global mental health and neurological problems.

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“…Portable LF MRI systems may be suitable for hospitalized patients, such as those in intensive care units or isolation wards, for whom transport to a standard clinical scanner carries unacceptable risk [ 7 – 10 ]. More broadly, portable LF MRI units could potentially be used in ambulances, emergency departments, physician’s offices or rural clinics [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%