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Maret, Susan

doi:10.5260/chara.18.2.17

Cited by 4 publications

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“…109,110 MTs are involved in metal (particularly zinc and copper) homeostasis and so participate in different ocular functions. MTs are key zinc buffers intracellularly 111 by accepting and releasing zinc ions in response to various stimuli. Given its role in the modulation of free zinc concentrations, MTs would be expected to be localized in regions where zinc is playing a regulatory role in a loosely-bound form readily exchanging binding sites.…”

Section: Retinal Zinc Homeostasismentioning

confidence: 99%

Recent advances in the understanding of the role of zinc in ocular tissues

Ugarte

Osborne

2014

Metallomics

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Zinc levels are high in ocular tissues and the distribution is non-uniform. Zinc is particularly concentrated in the corneal epithelium and posterior stroma. Zinc is the most abundant trace metal in the retina. Bound-zinc is particularly located in the inner nuclear layer, (e.g. forming part of the structure of zinc finger transcription factors), while loosely-bound zinc is prominent in the retinal pigment epithelium and photoreceptor layers. Loosely-bound zinc ions in the photoreceptors might play a role in the phototransduction cascade and rhodopsin regeneration. Loosely-bound zinc is also found in presynaptic vesicles of photoreceptor cells in the outer plexiform and inner plexiform layers and can be synaptically released to affect both ionotropic and metabotropic receptors and also ion channels to modulate neurotransmission. The correct amount of loosely-bound zinc ions is maintained by regulating the function of zinc transporters, sensors and trafficking/storage proteins (i.e. metallothionein). The retinal homeostasis of zinc is dysregulated in systemic zinc depletion, aging and diseases such as age-related macular degeneration. Manipulation of retinal zinc metabolism in these situations might improve visual function.

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Section: Retinal Zinc Homeostasismentioning

confidence: 99%

Recent advances in the understanding of the role of zinc in ocular tissues

Ugarte

Osborne

2014

Metallomics

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The bio-relevant metals of the periodic table of the elements

Sigel

2019

Zeitschrift Für Naturforschung B

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The bio-relevant metals (and derived compounds) of the Periodic Table of the Elements (PTE) are in the focus. The bulk elements sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca) from the s-block, which are essential for all kingdoms of life, and some of their bio-activities are discussed. The trace elements of the d-block of the PTE as far as they are essential for humans (Mn, Fe, Co, Cu, Zn, Mo) are emphasized, but V, Ni, Cd, and W, which are essential only for some forms of life, are also considered. Chromium is no longer classified as being essential. From the p-block metals only the metalloid (half-metal) selenium (Se) is essential for all forms of life. Two other metalloids, silicon and arsenic, are briefly mentioned, but they have not been proven as being essential for humans. All metals of the PTE and a plethora of their compounds are used in industry and many of them are highly toxic, like lead (Pb), which is discussed as a prime example. Several metals of the PTE, that is, their ions and complexes, are employed in medicine and we discuss the role of lithium, gallium, strontium, technetium, silver, gadolinium (the only f-block element), platinum, and gold.

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“An Idyl of a Berry Pasture”: A Rediscovered Mary Wilkins Freeman Story

Aydelott¹,

Wilkins²

2015

Resources for American Literary Study

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In 1889, Mary E. Wilkins Freeman published a short story called “An Idyl of a Berry Pasture” in Once a Week, an early imprint of Collier's Weekly. Since that time, the story has been lost. Rediscovered, the tale depicts a meeting between the impoverished Viola Bell and the upstanding Elisha Burney and Viola's unsuccessful attempt to win his heart. Besides realistic dialect, careful descriptions of nature and village life, and pointed observations about the domestic lives and attitudes of New England men and women, Freeman revisits themes of poverty and class distinctions, and the polarities of freedom and safety, masculinity and femininity, authenticity and conformity, and individual and community. Published at a time when Freeman had established herself as a writer of the New England soil, and containing hallmarks of her best work, “An Idyl of a Berry Pasture” deserves placement among Freeman's strong and evocative New England stories.

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Accessible Archives

Cited by 4 publications

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Recent advances in the understanding of the role of zinc in ocular tissues

Recent advances in the understanding of the role of zinc in ocular tissues

The bio-relevant metals of the periodic table of the elements

“An Idyl of a Berry Pasture”: A Rediscovered Mary Wilkins Freeman Story

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