Access to γ‐Iodo‐gem‐Diborylated Cyclopentanes and to Bicyclic Cyclopropanes
Dace Circule,
Fabrice Dénès,
Philippe Renaud
Abstract:A formal atom transfer radical [3+2] annulation (ATRAn) reaction between different homoallyl radical precursors and 1,1‐diborylethene was developed. It provides a rapid access to polysubstituted cyclopentanes containing a gem‐diboronic ester moiety. The synthetic utility of theses uniquely functionalized 5‐membered rings is highlighted by their easy conversion to attractive borylated building blocks such as 1‐borylated bicyclo[3.1.0]hexanes. The ATRAn reaction was extended to homopropagylic radicals giving acc… Show more
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