Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3‐Azabicyclo[4.1.0]hept‐4‐enes

Abstract

A series of substituted 3-azabicyclo[4.1.0]hept-4-ene derivatives were prepared and analysed by cyclic voltammetry. Preparative aerobic electrochemical oxidation reactions were then carried out. Three original endoperoxides were isolated, characterised and subjected to antimalarial and cytotoxicity activity assays.

Advances in the synthesis of 1,2-dioxolanes and 1,2-dioxanes

“…100,101 A vinylogous process was also explored from some piperidine derivatives Laurent Ferrié BioCIS Université Paris-Saclay and proved to be effective. 102 As described by Wimalesena and coworkers, the main difficulty in this study was the instability of the amino-dioxolanes. Only few examples were found to be stable and isolable.…”

Use of Electrochemistry in the Synthesis of Heterocyclic Structures

“…On the basis of this observation, the authors expanded the electrochemical oxidation process to more complex 3-azabicyclo­[4,1,0]­hept-4-ene derivatives 491 . Under similar electrolytic conditions, as shown in Scheme , the corresponding endoperoxides 492 were generated, although in low yields.…”