Access to infertility care and ART treatment in India: A clinician's perspective

GA, Ramaraju; Muvvala, Sanni Prasada Rao

doi:10.1016/j.bpobgyn.2022.102302

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Infertility is a condition characterized by the inability of a woman to conceive after a year of regular, unprotected intercourse. It poses a significant global health concern, affecting approximately 15% of couples worldwide, with female factors alone accounting for at least 35% [1][2][3]. Beyond the physiological challenges, long-term infertility can lead to emotional distress, strained relationships, and societal stigma, impacting the overall well-being of couples aspiring to have children [4].…”

Section: Introductionmentioning

confidence: 99%

Connecting the dots: the role of fatigue in female infertility

Li,

Huang,

Wei

et al. 2024

Reprod Biol Endocrinol

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Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model. Its persistence not only significantly compromises an individual’s quality of life but also correlates with chronic organ damage. Surprisingly, the intricate relationship between fatigue and female reproductive health, specifically infertility, remains largely unexplored. Our exploration into the existing body of evidence establishes a compelling link between fatigue with uterine and ovarian diseases, as well as conditions associated with infertility, such as rheumatism. This observation suggests a potentially pivotal role of fatigue in influencing overall female fertility. Furthermore, we propose a hypothetical mechanism elucidating the impact of fatigue on infertility from multiple perspectives, postulating that neuroendocrine, neurotransmitter, inflammatory immune, and mitochondrial dysfunction resulting from fatigue and its co-factors may further contribute to endocrine disorders, menstrual irregularities, and sexual dysfunction, ultimately leading to infertility. In addition to providing this comprehensive theoretical framework, we summarize anti-fatigue strategies and accentuate current knowledge gaps. By doing so, our aim is to offer novel insights, stimulate further research, and advance our understanding of the crucial interplay between fatigue and female reproductive health.

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Section: Introductionmentioning

confidence: 99%

Connecting the dots: the role of fatigue in female infertility

Li,

Huang,

Wei

et al. 2024

Reprod Biol Endocrinol

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“…20 During ICSI the sperm is directly injected into the ooplasm, which leads to bypassing the zona reaction and sperm oocyte penetration. [21][22][23][24][25] Furthermore, ICSI increases the probability of fertilization rate which leads to an increase in success rate. 26 Sperm have three main structural regions: the head, midpiece, and tail (flagellum).…”

Section: Introductionmentioning

confidence: 99%

Impact of Oocytes with Mild and Heavy Debris in Perivitelline Space on Blastocyst Quality

Ram,

Chandan,

Mahalakshmi

et al. 2023

Journal of Obstetric and Gynaecological Practices POGS

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Aim:The aim of this study is to compare the blastocyst quality of oocytes with mild and heavy debris in perivitelline space (DPVS). Objective: To investigate the rate of blastocyst development of oocytes with mild DPVS and to investigate the rate of blastocyst development of oocytes with heavy DPVS, then to compare the rate of blastocyst development of oocytes with mild and heavy DPVS and to identify ideal blastocyst for transfer. Study population: Patients who have undergone controlled ovarian stimulation for the intracytoplasmic sperm injection (ICSI) cycle from March 2023 to May 2023 ARC International Fertility and Research Centre. Study groups: Two groups were considered-oocytes with mild debris or granularity in perivitelline space (PVS) and oocytes with heavy debris or granularity in PVS. Results: This study from March 2023 to May 2023 was done at ARC International Fertility and Research Centre. Patients undergoing the Antagonist protocol for the ICSI cycle were considered. Around 371 M2 oocytes were analyzed, in that 203 had mild debris or granularity in PVS and 168 had heavy debris or granularity in PVS.In oocytes with mild debris or granularity in PVS, their fertilization rate, cleavage rate, and frozen blastocyst rate are 88, 81, and 47%, respectively. In oocytes with heavy debris or granularity in PVS their fertilization rate, cleavage rate, and frozen blastocyst rate are 76, 59, and 15%, respectively. Oocytes with heavy debris or granularity in PVS have compromised blastocyst quality compared with mild debris or granularity in PVS. Conclusion:In this study, we conclude that debris or granularity in PVS can be considered an indicator of oocyte competence. This can help in identifying a cohort of oocytes with a lower chance of forming viable embryos. This helps in reducing the culture of supernumerary embryos. We suggest that when the patients enroll for donor oocytes, oocytes without heavy debris or granularity in PVS should be used because heavy granularity in PVS has compromised blastocyst conversion. Further studies are needed with a large sample size to get a conclusion.

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Preface: Health economics and outcomes research in reproductive medicine: Methods and comparative effectiveness of treatment protocols

D'Hooghe

2024

Best Practice & Research Clinical Obstetrics & Gynaecol

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Access to infertility care and ART treatment in India: A clinician's perspective

Cited by 3 publications

References 27 publications

Connecting the dots: the role of fatigue in female infertility

Connecting the dots: the role of fatigue in female infertility

Impact of Oocytes with Mild and Heavy Debris in Perivitelline Space on Blastocyst Quality

Preface: Health economics and outcomes research in reproductive medicine: Methods and comparative effectiveness of treatment protocols

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