Access to females and early life castration individually extend maximal but not median lifespan in male mice

Garratt, Michael; Try, Heather; Brooks, Robert C.

doi:10.1007/s11357-020-00308-8

Cited by 6 publications

(7 citation statements)

References 44 publications

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“…Mating without additional odour exposure tended to reduce male mortality compared to unmated males without odour exposure (Chi squared test for proportion alive: Chi-square statistic = 3.35, d.f. = 1, p = 0.067), as previously reported [22]; however, mating with additional odour exposure reversed this effect and led to males showing increased mortality compared to other groups (figure 1a).…”

Section: (A) the Effect Of Odour Exposure And Mating On Mortalitysupporting

confidence: 82%

“…We expected that some mice would die by 24 months of age, but with an initial sample size of 30 per group we would have sufficient power to determine effects of social environments on reproductive senescence that have previously been reported. Animals were exposed to differing social environments starting at 40 weeks of age, because in our previous study we had noted slightly increased mortality in mating environments earlier in life [22], and we wished to mitigate these effects by pairing males later in life.…”

Section: (B) Experimental Designmentioning

confidence: 99%

“…In male mice, it has been shown that alterations in metabolic rate and body weight with mating are linked to olfactory perception of female odorants via specific neurons in the accessory olfactory system [21]. Long-term effects of female odours on male lifespan or ageing have not been reported, although housing male rodents with females throughout life can improve survival [22] and reduce reproductive senescence [23]. This suggests that mating and/or a cue associated with female presence influences aspects of ageing in male mice.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice

Garratt,

Try,

Neyt

et al. 2024

Proc. R. Soc. B.

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Theories of ageing predict that investment in reproduction will trade-off against survival and later-life reproduction. Recent evidence from invertebrates suggests that just perceiving cues of a potential mate's presence can reduce lifespan, particularly in males, and that activation of neuroendocrine reward pathways associated with mating can alleviate these effects. Whether similar effects occur in vertebrates remains untested. We tested whether exposure to olfactory cues from the opposite sex would influence mortality and reproductive senescence in male mice. We observed that males exposed to female olfactory cues from middle- to old age (from 10 to 24 months of age) showed reduced late-life fertility, irrespective of whether they had also been allowed to mate with females earlier in life. Males that were exposed to female odours in conjunction with mating also showed an increased mortality rate across the exposure period, indicating that olfactory cues from females can increase male mortality in some environments. Our results show that exposure to female odours can influence reproductive ageing and mortality in male mice, highlighting that sensory perception of mates may be an important driver of life-history trade-offs in mammals.

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Section: (A) the Effect Of Odour Exposure And Mating On Mortalitysupporting

confidence: 82%

Section: (B) Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice

Garratt,

Try,

Neyt

et al. 2024

Proc. R. Soc. B.

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“…Castration did not show benefit when the castration was performed at the time around or after puberty (Bame et al, 2012). In contrast, when the castration was done during or before puberty, potentially lifespan expansion was observed (Garratt et al, 2021).…”

Section: Confused Data From Animal Modelsmentioning

confidence: 87%

“…Laboratory animals, such as mice and rats can be used for such a study. They are widely used animal models and the studies can be done under controlled same environment within the same species (Garratt et al, 2021).…”

Section: It Is Possible To Test the Hypothesis By A Variety Of Studiesmentioning

confidence: 99%

Testosterone and lifespan in males: At the right time and the right level

Wang

Yin

2022

Andrologia

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It is well known that sex features of humans are mainly regulated by sex hormones. For men, testosterone made from the testicle is the primary sex hormone. During puberty, stimulated by sex determining region Y (SRY), testosterone facilitates the development of male features such as body and facial hair, deeper voice, muscle strength, and bone mass (Dufty, 1989). In adult females, testosterone concentrations are about 15-fold lower than that in males and androgen precursors are converted to estrogens. Whilst testosterone has been recognized as the major factor for the physiological features of male,

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Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice

Garratt¹,

Neyt²,

Ladyman³

et al. 2023

iScience

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Access to females and early life castration individually extend maximal but not median lifespan in male mice

Cited by 6 publications

References 44 publications

Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice

Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice

Testosterone and lifespan in males: At the right time and the right level

Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice

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