Access to bone mineral density testing in patients at risk for osteoporosis

Solomon, Daniel H.; Truppo, Colleen; Egan, Catherine; Jan, S.; Patel, Mrinali; Weiß, Thomas; Chen, Y. T.; Brookhart, M. Alan

doi:10.1007/s00198-006-0180-4

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Unlike the acute or life threatening nature of these conditions, however, DXA is often performed as a screening test and thus the impetus to perform it may be less compelling. Correspondingly, given less perceived need to obtain testing, barriers to access may be even more important [15, 16], A previous report that evaluated the relationship between travel distance and receipt of DXA in New Jersey found only a weak relationship [21]. However, as the authors pointed out, New Jersey is a relatively small, urban state and travel distance were likely shorter than would be expected in other states with a higher proportion of rural residents.…”

Section: Discussionmentioning

confidence: 99%

The geographic availability and associated utilization of dual-energy X-ray absorptiometry (DXA) testing among older persons in the United States

et al. 2008

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Section: Discussionmentioning

confidence: 99%

The geographic availability and associated utilization of dual-energy X-ray absorptiometry (DXA) testing among older persons in the United States

et al. 2008

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“…Although measuring BMD using dual energy X-ray absorptiometry (DXA) has been associated with lower hip fracture rates (1), as few as 32% of patients with indications for osteoporosis screening undergo BMD testing (2). Even in high-risk populations, average BMD testing rates were 8% in patients with fractures and 9% in patients using oral glucocorticoids (3–5).…”

Section: Introductionmentioning

confidence: 99%

Utility of Heel Dual-Energy X-ray Absorptiometry in Diagnosing Osteoporosis

Chou

Hwang

et al. 2014

Journal of Clinical Densitometry

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While peripheral dual energy X-ray absorptiometry (DXA) measurements have been found to predict fractures in population studies of Caucasians, little is known about their utility in other races and in patients with higher fracture risk. In a cross-sectional study of 874 women referred for bone mineral density (BMD) testing, we examined the utility of heel BMD in African-American (AA) compared to Caucasian (CA) women and in women using glucocorticoids. The ability of heel T-score to predict central osteoporosis was similar in AA and CA women (OR per 1 unit decrease in T-score of 2.79 [CI 2.16–3.60] and 3.15 [CI 2.53–3.92], respectively). The association between heel T-score and prevalent vertebral fractures was also similar in the two races (OR 1.46 [CI 1.15–1.85] in AA and 1.42 [CI 1.16–1.74] in CA). In women using glucocorticoids heel T-score was better than central T-score in predicting presence of vertebral fractures (OR 1.38 [CI 1.03–1.85] and 1.22 [CI 0.86–1.73], respectively). We conclude that in a multiracial referral population heel BMD predicts central osteoporosis and prevalent vertebral fractures equally well in AA as in CA women and may be better than central BMD in assessing fragility in glucocorticoid users.

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“…5 The most serious condition is hip fracture, such as femoral neck fracture or femur intertrochanteric fracture, because of the high morbidity and associated mortality and their attendant high-cost treatments. 7 Thus, the ultimate goal of the pharmacologic treatment of patients with osteoporosis is to reduce the risk of fractures by increasing their bone mass to a normal quality. Moreover, fractures at a number of other sites also are more frequent in osteoporotic bones than in healthy bones.…”

Section: Introductionmentioning

confidence: 99%

Acute and Subacute Oral Toxicity Tests of Sintered Dicalcium Pyrophosphate on Ovariectomized Rats for Osteoporosis Treatment

Yang

Wang

et al. 2010

Biomed. Eng. Appl. Basis Commun.

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Sintered dicalcium pyrophosphate (SDCP) is a synthetic pyrophosphate analog that could be utilized in the treatment for osteoporosis. In this study, an ovariectomized rat model is used to evaluate the systematic toxicity of orally administered SDCP relative to its effects on bone mass. Ovariectomized Wistar rats were treated with experimental medication with different dosing strategies (0.5 mg/kg five days weekly, and 2.5 mg/kg once weekly) for once (acute oral toxicity test) and four weeks (subacute oral toxicity test) followed by recovery period. Clinical signs of toxicity, body weight, and food consumption of rats were recorded. Blood samples were collected for hematological and blood biochemical analyses. Rats were sacrificed for necropsy and major visceral organs were harvested for histological examination after the recovery period. Long bones of four limbs were harvested to evaluate the effects of SDCP on bone mass. Results showed that there was no change in clinical signs, body weight, food consumption, hematology, blood biochemistry, necropsy, and histological examination attributable to the oral administration with SDCP to rats during the dosing period and the recovery period. Analysis of bone ashes revealed that the ovariectomized rats ingested with 0.5 mg/kg SDCP five days weekly continually for four weeks increased bone mineral contents significantly. In the ovariec-169 Biomed. Eng. Appl. Basis Commun. 2010.22:169-176. Downloaded from www.worldscientific.com by NANYANG TECHNOLOGICAL UNIVERSITY on 08/26/15. For personal use only.tomized rats ingested with 2.5 mg/kg SDCP once weekly continually for four weeks, the bone mineral contents were increased to normal bone quality. This study indicates that the SDCP can increase bone mass in the ovariectomized rat with no deleterious effects.

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Access to bone mineral density testing in patients at risk for osteoporosis

Abstract: Among beneficiaries of one large health insurer in New Jersey, two different measures of access to BMD testing were not important predictors of receiving testing and/or medications for osteoporosis.

Cited by 8 publications

References 10 publications

The geographic availability and associated utilization of dual-energy X-ray absorptiometry (DXA) testing among older persons in the United States

The geographic availability and associated utilization of dual-energy X-ray absorptiometry (DXA) testing among older persons in the United States

Utility of Heel Dual-Energy X-ray Absorptiometry in Diagnosing Osteoporosis

Acute and Subacute Oral Toxicity Tests of Sintered Dicalcium Pyrophosphate on Ovariectomized Rats for Osteoporosis Treatment

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