Access schedules mediate the impact of high fat diet on ethanol intake and insulin and glucose function in mice

Coker, Caitlin R.; Aguilar, Elizabeth; Snyder, Angela E.; Bingaman, Sarah S.; Graziane, Nicholas; Browning, Kirsteen N.; Arnold, Amy C.; Silberman, Yuval

doi:10.1016/j.alcohol.2020.03.007

Cited by 11 publications

(11 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our recent work indicates that an intermittent HFD model using repeated acute HFD access periods once per week and intermittent, limited access to EtOH on days HFD is not given significantly increases EtOH intake in mice compared to both continuous control and HFD diet access (Coker et al, 2020). This is in contrast to other studies that show intermittent high fat/high sucrose diets given twice a week or more reduce EtOH intake in rats (Sirohi et al, 2017b).…”

Section: Clinical and Preclinical Studies Of High Fat Diet-induced Alcohol Intakecontrasting

confidence: 60%

“…The two-bottle choice model is a voluntary consumption model providing the animal a choice between a bottle containing an EtOH solution (typically in water, but other vehicles may be used) and a second bottle containing water (or vehicle). This model allows for behavioral analysis of intake including assessment of EtOH preference and consumption, typically in a home cage setting (Coker et al, 2020). Access schedules to the EtOH solution can be readily altered to induce binge-like intake (Melendez, 2011;Thiele et al, 2014) and allows for discrete time periods for access to EtOH and HFD.…”

Section: Animal Models Of Alcohol Intakementioning

confidence: 99%

“…The well-known physiological consequences of obesity in the clinical population, such as insulin resistance, glucose intolerance, and increased risk for developing type II diabetes (Haslam and James, 2005), are recapitulated in rodent models. Animal studies show that both short-term and chronic HFD consumption results in glucose intolerance and insulin resistance as well as increased fasting glucose, insulin, free fatty acid, triglyceride, and leptin levels compared to regular chow diet (Hariri and Thibault, 2010;Paulson et al, 2010;Dutheil et al, 2016;Coker et al, 2020). Female mice are often shown as being more resistant to these HFD-induced physiological changes, potentially due to metabolically protective effects of estrogen (Gelineau et al, 2017).…”

Section: Changes By Dietmentioning

confidence: 99%

“…As discussed above, many of the discrepancies in the HFD and EtOH co-consumption literature may be due to differences in methodology of consumption between studies. To address this possibility, studies by our lab (Coker et al, 2020) show that differences in the scheduling of EtOH and HFD access mediate the amount of EtOH consumed and the resultant impact on insulin and glucose function. This study showed that moderate and binge EtOH consumption does not improve insulin sensitivity or glucose tolerance in HFDfed mice.…”

Section: Changes By Combination Of Diet and Alcoholmentioning

confidence: 99%

See 3 more Smart Citations

Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function

Coker

Keller

Arnold

et al. 2021

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

The prevalence of psychiatry disorders such as anxiety and depression has steadily increased in recent years in the United States. This increased risk for anxiety and depression is associated with excess weight gain, which is often due to over-consumption of western diets that are typically high in fat, as well as with binge eating disorders, which often overlap with overweight and obesity outcomes. This finding suggests that diet, particularly diets high in fat, may have important consequences on the neurocircuitry regulating emotional processing as well as metabolic functions. Depression and anxiety disorders are also often comorbid with alcohol and substance use disorders. It is well-characterized that many of the neurocircuits that become dysregulated by overconsumption of high fat foods are also involved in drug and alcohol use disorders, suggesting overlapping central dysfunction may be involved. Emerging preclinical data suggest that high fat diets may be an important contributor to increased susceptibility of binge drug and ethanol intake in animal models, suggesting diet could be an important aspect in the etiology of substance use disorders. Neuroinflammation in pivotal brain regions modulating metabolic function, food intake, and binge-like behaviors, such as the hypothalamus, mesolimbic dopamine circuits, and amygdala, may be a critical link between diet, ethanol, metabolic dysfunction, and neuropsychiatric conditions. This brief review will provide an overview of behavioral and physiological changes elicited by both diets high in fat and ethanol consumption, as well as some of their potential effects on neurocircuitry regulating emotional processing and metabolic function.

show abstract

Section: Clinical and Preclinical Studies Of High Fat Diet-induced Alcohol Intakecontrasting

confidence: 60%

Section: Animal Models Of Alcohol Intakementioning

confidence: 99%

Section: Changes By Dietmentioning

confidence: 99%

Section: Changes By Combination Of Diet and Alcoholmentioning

confidence: 99%

See 2 more Smart Citations

Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function

Coker

Keller

Arnold

et al. 2021

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this sense, consumption of HFD during adolescence may be a risk factor for the onset and escalation of excessive alcohol consumption in adulthood. The few studies that have explored how HFD bingeing impacts ethanol consumption have yielded diverging results depending on the access schedule used [ 55 , 56 ]. Some of these studies reported increases in alcohol intake after intermittent exposure to HFD [ 57 , 58 ], while other works observed a decrease in alcohol consumption following intermittent HFD [ 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

González-Portilla

Montagud‐Romero

Navarrete

et al. 2021

IJMS

View full text Add to dashboard Cite

Alcohol binge drinking (BD) and poor nutritional habits are two frequent behaviors among many adolescents that alter gut microbiota in a pro-inflammatory direction. Dysbiotic changes in the gut microbiome are observed after alcohol and high-fat diet (HFD) consumption, even before obesity onset. In this study, we investigate the neuroinflammatory response of adolescent BD when combined with a continuous or intermittent HFD and its effects on adult ethanol consumption by using a self-administration (SA) paradigm in mice. The inflammatory biomarkers IL-6 and CX3CL1 were measured in the striatum 24 h after BD, 3 weeks later and after the ethanol (EtOH) SA. Adolescent BD increased alcohol consumption in the oral SA and caused a greater motivation to seek the substance. Likewise, mice with intermittent access to HFD exhibited higher EtOH consumption, while the opposite effect was found in mice with continuous HFD access. Biochemical analyses showed that after BD and three weeks later, striatal levels of IL-6 and CX3CL1 were increased. In addition, in saline-treated mice, CX3CL1 was increased after continuous access to HFD. After oral SA procedure, striatal IL-6 was increased only in animals exposed to BD and HFD. In addition, striatal CX3CL1 levels were increased in all BD- and HFD-exposed groups. Overall, our findings show that adolescent BD and intermittent HFD increase adult alcohol intake and point to neuroinflammation as an important mechanism modulating this interaction.

show abstract

Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats

2023

View full text Add to dashboard Cite

Background Binge alcohol drinking is considered a prominent risk factor for the development of alcohol-use disorders, and could be model in rodents through the standard two-bottle preference choice test. The goal was to recreate an intermittent use of alcohol during 3 consecutive days each week to ascertain its potential impact on hippocampal neurotoxicity (neurogenesis and other neuroplasticity markers), and including sex as a biological variable, given the well-known sex differences in alcohol consumption. Methods Ethanol access was granted to adult Sprague–Dawley rats for 3 consecutive days per week, followed by 4 days of withdrawal, during 6 weeks, mimicking the most common pattern of intake in people, drinking over the weekends in an intensive manner. Hippocampal samples were collected to evaluate signs of neurotoxicity. Results Female rats consumed significantly more ethanol than males, although intake did not escalate over time. Ethanol preference levels remained below 40% over time and did not differ between sexes. Moderate signs of ethanol neurotoxicity were observed in hippocampus at the level of decreased neuronal progenitors (NeuroD + cells), and these effects were independent of sex. No other signs of neurotoxicity were induced by ethanol voluntary consumption when measured through several key cell fate markers (i.e., FADD, Cyt c, Cdk5, NF-L) by western blot analysis. Conclusions Overall, the present results suggest that even though we modeled a situation where no escalation in ethanol intake occurred across time, mild signs of neurotoxicity emerged, suggesting that even the use of ethanol during adulthood in a recreational way could lead to certain brain harm.

show abstract

Access schedules mediate the impact of high fat diet on ethanol intake and insulin and glucose function in mice

Cited by 11 publications

References 41 publications

Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function

Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats

Contact Info

Product

Resources

About