“…In addition to disparities in education, several reported that in rural areas, more individuals live below the poverty line compared with urban areas, which could limit the ability of rural individuals to meet research-related demands, such as cost for transportation, diagnostic testing and medication, as well as the time required to participate in clinical trials [18, 19, 22, 23]. Further, two reports concluded that compared with urban residents, rural individuals are more likely to report reduced health statuses and suffer from chronic conditions that compromise their ability to participate clinical research studies [24, 32]. In some cases, competing priorities in caring for their own chronic conditions and those of family members, as well as busy farming and ranching schedules, precluded individuals from participation [19, 22, 29].…”