“…In a general sense, prior research has indicated that use of certain soft drugs (alcohol, tobacco, marijuana) does precede the use of hard drugs (opioids, cocaine, amphetamines, etc.) in terms of progression (Cappelli et al, 2021; Kandel et al, 1992; Keyes et al, 2019). However, research regarding the mechanisms by which these relationships are posited to occur is a bit more equivocal.…”