Acceptability of prenatal diagnosis of sickle cell anaemia (SCA) by female patients and parents of SCA patients in Nigeria

Durosinmi, M. A.; Odebiyi, A.I.; Adediran, I A; Akinola, N. O.; Adegorioye, D.E.; Okunade, M A

doi:10.1016/0277-9536(94)00361-v

Cited by 39 publications

(50 citation statements)

References 8 publications

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“…25 To some extent, this attitude can be compared to that of Nigerian SCA female patients, who in more than 85%, would like prenatal diagnosis to be offered in Nigeria, but only 35% would opt for termination of an affected pregnancy. 26 Similarly, 78% of educated Nigerians would want prenatal diagnosis started in Nigeria and only 45% would opt for termination of affected pregnancy. 27 Although we do know that what people say they would do before the fact does not always predict what they actually choose to do when faced with a real decision, an evaluation of these attitudes might still give us an idea on how to initiate policy.…”

Section: Discussionmentioning

confidence: 99%

“…26 Similarly, 78% of educated Nigerians would want prenatal diagnosis started in Nigeria and only 45% would opt for termination of affected pregnancy. 27 Although we do know that what people say they would do before the fact does not always predict what they actually choose to do when faced with a real decision, an evaluation of these attitudes might still give us an idea on how to initiate policy.…”

Section: Discussionmentioning

confidence: 99%

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Knowledge and attitudes concerning medical genetics amongst physicians and medical students in Cameroon (sub-Saharan Africa)

Wonkam

Njamnshi

Angwafo

2006

Genetics in Medicine

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Purpose: Little is known about physician's knowledge of, and attitudes toward genetics in sub-Saharan Africa.Methods: Survey of 101 pre-clinical, 95 clinical medical students, and 110 physicians, in Cameroon. Results: The awareness of DNA diagnosis was poor: 0, 2.2, and 1.2%, respectively, for sickle cell anemia. The majority of the respondents considered genetic counseling as indispensable (97.6, 98.9 and 100%); and prenatal diagnosis as acceptable. The acceptance of medical abortion increased with the level of medical education (62.6, 74.7 and 90.7%). Sickle cell anemia was considered as a "serious disease" by a greater majority of respondents than Down syndrome (P Ͻ 0.001). But, in all three groups, the acceptance of termination of affected pregnancy "if the respondent's own child was affected" was lower for sickle cell anemia than Down syndrome (

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Knowledge and attitudes concerning medical genetics amongst physicians and medical students in Cameroon (sub-Saharan Africa)

Wonkam

Njamnshi

Angwafo

2006

Genetics in Medicine

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“…The prevalence of sickle cell anemia is approximately 20 per 1000 births, indicating that approximately 150,000 children are born annually in Nigeria with sickle cell anemia [1]. Nigeria has the largest concentration of patients with sickle cell anemia in the world [5].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Impairment among Patients with Sickle Cell Anemia

Williams¹,

Inyama²,

Ameh³

et al. 2017

Recent Advances in Biology and Medicine

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“…Each year about 300,000 infants are born with major hemoglobin disorders -including more than 200,000 cases of sickle-cell anemia in Africa [5,6] . In Nigeria, by far the most populous country in the sub-region, 24% of the population are carriers of the mutant gene (HbAS) and the prevalence of sicklecell anemia (HbSS) is about 2% [5,[7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Chronic Liver Disease among Adult Patients with Sickle Cell Anemia in Steady State in Ile-Ife, Nigeria

Oluwagbenga

Ndububa

Yusuf

et al. 2016

Journal of Gastroenterology and Hepatology Research

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those of 50 age-and sex-matched subjects with HbAA as controls. RESULTS: Each of the study groups (patients and controls) comprised of 21 (42%) males and 29 (58%) females. The age range of the patients was 18-45years with a mean (± SD) of 27.6 ± 7.607 while that of the controls was 21-43years with a mean (± SD) of 28.0 ± 5.079 (p = 0.746). Amongst the patients, 32 (64%) had hepatomegaly while 18 (36%) had normal liver ultrasound findings. In the control group, 1(2%) had fatty liver but none had hepatomegaly. Forty-nine (98%) of the controls had normal liver ultrasound findings. There was a statistically significant difference in the prevalence of hepatomegaly between the patients and controls with p value < 0.001. Twenty-four (48%) of the patients were in CTP class A; 7 (29.2%) males and 17 (70.8%) females, while the remaining 26 (52%) patients were in CTP class B; 14 (53.8%) males and 12 (46.2%) females. None of the patients was in CTP class C. CONCLUSION: In this study, hepatomegaly was a common ultrasound finding in patients with sickle cell anemia. It is essential to assess for evidence of liver disease in patients with sickle cell anemia even when they are not yet symptomatic. ABSTRACT AIM: Chronic liver disease encompasses a range of hepatic pathology arising from a wide variety of insults to the liver which can occur in patients with sickle cell anemia. This study is aimed to investigate the state of chronic liver disease among adult patients with sickle cell anemia in steady state attending the hematology clinic of a federal tertiary health institution in Ile-Ife, Nigeria. METHODS: Basic demographic data, liver ultrasound scan as well as liver function test and Child-Turcotte-Pugh class of 50 consecutive sickle cell anemia (HbSS) patients were compared with

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Acceptability of prenatal diagnosis of sickle cell anaemia (SCA) by female patients and parents of SCA patients in Nigeria

Cited by 39 publications

References 8 publications

Knowledge and attitudes concerning medical genetics amongst physicians and medical students in Cameroon (sub-Saharan Africa)

Knowledge and attitudes concerning medical genetics amongst physicians and medical students in Cameroon (sub-Saharan Africa)

Neuropsychiatric Impairment among Patients with Sickle Cell Anemia

Chronic Liver Disease among Adult Patients with Sickle Cell Anemia in Steady State in Ile-Ife, Nigeria

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