Acceptability of Mini-Tablets in Young Children: Results from Three Prospective Cross-over Studies

Klingmann, Viviane

doi:10.1208/s12249-016-0639-3

Cited by 34 publications

(21 citation statements)

References 9 publications

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“…Despite the promise hold by multi-particulate formulations these dosage forms are not yet a well-established platform mainly due to manufacture and administration constrains, such as weight control, content uniformity and handling by patients. The impact on adherence has not been yet studied even though higher acceptability and capacity to swallow mini-tablets over syrup has been demonstrated in the paediatric population [102,103].…”

Section: Multi-particulate Formulationsmentioning

confidence: 99%

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

et al. 2020

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Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients. Interventions for improving adherence need to consider the characteristics of the individual therapeutic regimens according to the needs of the patients. In particular, geriatric and paediatric populations as well as dermatological patients have special needs/preferences that should be considered when designing drug products. Patient Centric Drug Product Pharmaceutical Design (PCDPD) offers the opportunity to meet the needs and preferences of patients. Packaging, orodispersible formulations, fixed dose combinations products, multiparticulate formulations, topical formulations and 3D printing are of particular relevance in a PCDPD process. These will be addressed in this review as well as their impact on medication adherence.

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Section: Multi-particulate Formulationsmentioning

confidence: 99%

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

et al. 2020

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“…The various types of marketed oral dosage forms include solutions, syrups, suspensions, powders, granules, tablets, orally disintegrating tablets (ODT), chewable tablets, dispersible tablets, capsules, oral thin strips, chewing gums, powder for reconstitution, tablets for constituton to suspension, oral drops and troches [10] . Chewable tablets, orodispersible formulations such as ODT, orally disintegrating mini-tablets and orodispersible films (ODF) and multi-particulate formulations can be conveniently consumed by school going children and geriatric patients due to advantages like convenient administration and less swallowing difficulties [11][12][13][14][15] . A flexible tablet formulation administered as chewable tablets, ODT, orally dispersible tablets dispersed in a small quantity of water, and also be orally swallowed.…”

Section: Review Articlementioning

confidence: 99%

Solid Oral Flexible Formulations for Pediatric and Geriatric patients: Age-appropriate Formulation Platforms

Ch¹,

rasekaran²,

Ruckmani³

et al. 2018

pharmaceutical-sciences

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Chandrasekaran and Kandasamy: Solid Oral Flexible Formulation Platform for Paediatrics and Geriatrics The oral route of drug administration is mostly preferred by paediatric and geriatric patients. Patient non-compliance due to poor taste and swallowing problems are major issues in paediatric and geriatric drug therapy. Lack of age-appropriate formulations, inadequate labelling instructions, non-compatible and non-palatable medicines are the main reasons for medication errors in paediatric patients. This review mainly highlights major issues of paediatric and geriatric drug therapy and provides the design of oral flexible formulations as an alternative formulation design for age appropriate formulation development. Development of solid oral flexible formulations as an alternative to existing marketed formulations such as conventional tablets, orally disintegrating tablets, chewable and dispersible tablets for paediatric and geriatrics patients is described. Details about drug properties, excipient selection and taste masking approaches were described. The need for bioavailability and bioequivalence studies for flexible formulations also described. Development of flexible formulations as an alternative to marketed different formulations of the same drug would reduce the cost of the formulation for patients particularly developing countries where accessibility to various types of formulations is less. Flexible tablet formulations can be conveniently used by the patients as orally swallowable, orally disintegrating, chewable and as dispersible tablets. Sprinkle formulations such as pellets, granules packed in capsules or sachets can be conveniently used by paediatric and geriatric patients. Properly designed and developed flexible formulations for new chemical entities and off-patent drugs are need of the hour to provide better treatment to varying age groups of paediatrics and geriatrics.

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“…Recently, the miniaturization of tablets has emerged as a focus of pharmaceutical research. 1,2) Mini-tablets, defined by WHO as tablets with a diameter of ≤4 mm, 3) have attracted attention as a new dosage form to improve adherence, and their pharmaceutical and clinical suitability has been investigated. 4,5) Many pharmaceutical aspects have been studied, including the development of mini-tablets with a diameter of 1-2 mm to increase miniaturization, enhance dissolution control, and the improvement of absorption by modification of the tablet surfaces.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Weight Variation in Mini-Tablets Manufactured by a Multiple-Tip Tool

Kurashima

Uchida

Kashiwagura

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

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Recently, owing to their pharmaceutical and clinical utility, mini-tablets have been well studied by researchers. Mini-tablets are usually manufactured by compression molding using a multiple-tip tool in a rotary tableting machine. Owing to their special structure, ensuring uniformity is a very important challenge in the manufacturability of mini-tablets using the multiple-tip tool. In this study, we aimed to evaluate the weight variation in mini-tablets produced by a multiple-tip tool, which is considered to be the root cause affecting the uniformity, and to investigate the physical properties of drug granules and tableting conditions in a rotary tableting machine that could reduce this weight variation. In addition, the relationship between these factors and response was visualized using response surface analysis. It was shown that the weight variation in mini-tablets produced by a multiple-tip tool was reduced when using a forced feeder compared with an open feeder. Furthermore, in the case of an open feeder, the optimal range of the average particle size diameter of drug granules and the rotational speed of the rotating disc in the rotary tableting machine were determined from response surface analysis. It was suggested that it is possible to reduce the weight variation in the mini-tablets by selecting drug granules with an average particle size diameter of 100-150 µm and using tableting conditions with a rotational speed of 40-60 rpm. This study elucidated the factors that affect uniformity and determined their optimal range for the manufacture of mini-tablets.

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Acceptability of Mini-Tablets in Young Children: Results from Three Prospective Cross-over Studies

Cited by 34 publications

References 9 publications

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

Solid Oral Flexible Formulations for Pediatric and Geriatric patients: Age-appropriate Formulation Platforms

Evaluation of Weight Variation in Mini-Tablets Manufactured by a Multiple-Tip Tool

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