Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial

Abstract

Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. However, many individuals encounter barriers that limit the uptake of face-to-face exercise. Technology-enabled interventions offer a distance-based alternative. This pilot study aimed to explore the acceptability, safety and preliminary efficacy of a web-based exercise intervention (ExerciseGuide) in individuals with metastatic prostate cancer. Forty participants (70.2 ± 8.5 years) with metastatic prostate cancer were randomised into the 8-week intervention (N = 20) or a wait-list control (N = 20). The intervention arm had access to a computer-tailored website, personalised exercise prescription and remote supervision. ExerciseGuide was deemed acceptable with a score ≥20 on the client satisfaction questionnaire; however, the usability score was just below the pre-specified score of ≥68 on the software usability scale. There were no serious adverse events reported. Moderate-to-vigorous physical activity levels between baseline and follow-ups were significantly higher (10.0 min per day; 95% CI = (1.3–18.6); p = 0.01) in the intervention group compared to wait-list control. There were also greater improvements in step count (1332; 95% CI = (159–2505); p = 0.02) and identified motivation (0.4, 95% CI = (0.0, 0.7); p = 0.04). Our findings provide preliminary evidence that ExerciseGuide is acceptable, safe and efficacious among individuals with metastatic prostate cancer.

Feasibility of a tailored and virtually supported home exercise program for people with multiple myeloma using a novel eHealth application

“…Taken together, these results support the program's feasibility. This suggests that, consistent with the findings of other malignancy groups, [23][24][25][26] an eHealth intervention is a feasible way to deliver an exercise intervention to individuals with MM. This program included three key elements which likely bolstered the program's feasibility: (1) tailoring, (2) virtual supervision/active support, and (3) trained personnel.…”

“…22 Recent trials have found eHealth interventions to be feasible and acceptable in older adults with cancer, 23,24 individuals with thoracoabdominal malignancies, 25 and individuals with metastatic prostate cancer. 26 Other trials identify the promise of eHealth interventions for outcomes such as fatigue, strength, pain, and functional capacity in various cancer populations. 27,28 The purpose of this study was to determine the safety, feasibility, and preliminary efficacy of a 12-week virtually supported home exercise program.…”

Exercise Intervention for Bone Metastasis: Safety, Efficacy and Method of Delivery

“…Of the 26 included trials, one trial was a non-randomised clinical trial [ 8 ] and the remaining 25 were randomised controlled trials (RCT) [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Twelve trials (46.2%) assessed only participants with bone metastases; the remaining fourteen (53.8%) included both participants with and without bone metastases.…”

“…A total of 1777 participants were included in the present review; of which 1319 participants (74.2%) had bone metastases, and 1132 participants (63.7%) were allocated to an exercise intervention ( Figure 2 ). Seventeen trials (65.4%) included participants with prostate cancer [ 8 , 9 , 10 , 11 , 13 , 14 , 15 , 17 , 20 , 21 , 22 , 23 , 24 , 26 , 30 , 31 , 32 ]; 11 trials (42.3%) included participants with breast cancer [ 8 , 10 , 12 , 14 , 17 , 18 , 19 , 20 , 22 , 27 , 34 ]. Trials that recruited participants with mixed tumours (including breast and prostate) accounted for 65.4% (17 trials) [ 8 , 10 , 14 , 17 , 20 , 22 , 25 , 28 , 29 , 32 , 34 ] ( Figure 2 ).…”

Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree

“…Essentially, IF an individual selects a statement, THEN they will be shown a pre-determined answer. ExerciseGuide UK has been adapted from previous versions of ExerciseGuide [7][8][9][10][11]. A detailed protocol of the adaptation and redevelopment of ExerciseGuide UK has been published [12].…”