Accelerometer-measured sedentary time and cardiometabolic biomarkers: A systematic review

Abstract

Total sedentary time was consistently shown to be associated with poorer insulin sensitivity, even after adjusting for time spent in physical activity. This finding supports the proposed association between sedentary time and the development of Type 2 diabetes and reinforces the need to identify interventions to reduce time spent sedentary.

El sedentarismo se asocia a un incremento de factores de riesgo cardiovascular y metabólicos independiente de los niveles de actividad física

“…Los resultados encontrados en la presente investigación concuerdan con numerosos estudios que han sido resumidos en revisiones sistemáticas y metaanálisis recientes [20][21][22] . Brocklebank y cols., en una revisión sistemática, identificaron 28 estudios que reportaron asociación entre sedentarismo y factores de riesgo cardiovascular, donde los mayores efectos nocivos del sedentarismo fueron observados en marcadores de diabetes mellitus, incluyendo, glicemia, insulina y marcadores de resistencia a la insulina 20 .…”

“…Brocklebank y cols., en una revisión sistemática, identificaron 28 estudios que reportaron asociación entre sedentarismo y factores de riesgo cardiovascular, donde los mayores efectos nocivos del sedentarismo fueron observados en marcadores de diabetes mellitus, incluyendo, glicemia, insulina y marcadores de resistencia a la insulina 20 . Por su parte, Wilmot y cols., en un metaanálisis encontraron que individuos con altos niveles de sedentarismo presentan un riesgo de desarrollar diabetes 112% mayor en comparación a aquellos que destinan menor tiempo a actividades sedentarias 21 .…”

Adding exercise or subtracting sitting time for glycaemic control: where do we stand?

“…Recent epidemiological evidence, including a harmonised meta-analysis of 16 prospective studies with over 1 million individuals (2-18 years follow-up) [1] probably confirm what the Diabetologia readership already suspected-too much sitting and too little physical activity are bad news. Indeed, these studies indicate that low levels of physical activity and large volumes of sedentary time (sitting) are jointly associated with increased cardiometabolic morbidity and mortality in a dose-dependent manner [1][2][3][4][5][6][7]. However, for many of those with type 2 diabetes, the more pertinent question continues to linger: what are the most effective countermeasures?…”

“…The study by Duvivier and colleagues [8] is an important addition to the rapidly expanding evidence base on the glycaemic consequences of excessive sitting [7,[12][13][14][15]. However, only one previous experimental study has examined the effects of breaking up prolonged sitting with brief, intermittent bouts of light-intensity activities in a sample of type 2 diabetes patients, albeit under controlled experimental conditions [16].…”

Two consecutive lapses in participation in a weekend exercise program may lessen the benefit of the intervention for hyperglycemia

“…Recently, the amount and pattern of sedentary behavior have also been studied. A review by Brocklebank suggested that longer total sedentary time decreased insulin sensitivity, but breaks in sedentary time had no effect on insulin sensitivity 2) . In addition, cross-sectional analysis of total amount and patterns of sedentary behavior and type 2 diabetes has also suggested that each additional hour of sedentary time increases the prevalence of type 2 diabetes, but the number of sedentary breaks, number of prolonged sedentary bouts and average bout duration did not affect glucose metabolism 3) .…”