The efficiency of telestroke programs in improving the rates of recombinant
tissue plasminogen activator (rtPA) in stroke patients has been reported.
Previous studies have reported favorable treatment outcomes with the use of
telestroke programs to improve the use of rtPA, but functional outcomes are not
fully understood. This study investigated the effect of telestroke technology in
the administration of rtPA and related functional outcomes associated with
baseline clinical variables. Retrospective data of a telestroke registry were
analyzed. Univariate analysis was used to compare demographic and clinical
variables in the rtPA group and the no rtPA group and between the improved
functional ambulation group and the no improvement group. A stepwise binary
logistic regression identified factors associated with improved functional
outcome in the total telestroke population and in the subset of the telestroke
population who received rtPA. In adjusted analysis and elimination of any
multicollinearity for patients who received rtPA in the telestroke setting,
obesity (odds ratio [OR] = 2.138, 95% confidence interval [CI], 1.164-3.928,
P < .05), higher systolic blood pressure at the time of
presentation (OR = 1.015, 95% CI, 1.003-1.027, P < .05), and
baseline high-density lipoprotein at the time of admission (OR = 1.032, 95% CI,
1.005-1.059, P < .05) were associated with improved
functional outcomes. Increasing age (OR = 0.940, 95% CI, 0.916-0.965,
P < .0001) and higher calculated National Institutes of
Health Stroke Scale (OR = 0.903, 95% CI, 0.869-0.937) were associated with a
poorer outcome in rtPA-treated patients. Telestroke technology improves
functional outcomes at spoke stations where neurological expertise is
unavailable. Further studies are necessary to determine how telestroke
technology can be optimized, especially to improve contraindications and
increase eligibility for thrombolysis therapy.