Accelerator-based analytical technique in the study of some anti-diabetic medicinal plants of Nigeria

Olabanji, S.O.; Omobuwajo, O.R.; Ceccato, D.; Adebajo, AC; Buoso, M.C.; Moschini, G.

doi:10.1016/j.nimb.2008.03.016

Cited by 15 publications

(8 citation statements)

References 4 publications

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“…The decoction/infusion of the root of the plant is also used as an antidiabetic. 14 Antiinflammatory 15 and antitrypanosomal 16 activities of the plant have also been reported.…”

Section: Introductionmentioning

confidence: 94%

Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae)

Akindele

Wani

Mahajan

et al. 2015

Journal of Traditional and Complementary Medicine

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Cancer is a leading cause of death worldwide and sustained focus is on the discovery and development of newer and better tolerated anticancer drugs especially from plants. The sulforhodamine B (SRB) in vitro cytotoxicity assay, sarcoma-180 (S-180) ascites and solid tumor, and L1210 lymphoid leukemia in vivo models were used to investigate the anticancer activity of root extracts of Aristolochia ringens Vahl. (Aristolochiaceae; 馬兜鈴 mǎ dōu líng). AR-A001 (IC50 values of 20 μg/mL, 22 μg/mL, 3 μg/mL, and 24 μg/mL for A549, HCT-116, PC3, and THP-1 cell lines, respectively), and AR-A004 (IC50 values of 26 μg/mL, 19.5 μg/mL, 12 μg/mL, 28 μg/mL, 30 μg/mL, and 22 μg/mL for A549, HCT-116, PC3, A431, HeLa, and THP-1, respectively), were observed to be significantly active in vitro. Potency was highest with AR-A001 and AR-A004 for PC3 with IC50 values of 3 μg/mL and 12 μg/mL, respectively. AR-A001 and AR-A004 produced significant (p < 0.05–0.001) dose-dependent inhibition of tumor growth in the S-180 ascites model with peak effects produced at the highest dose of 120 mg/kg. Inhibition values were 79.51% and 89.98% for AR-A001 and AR-A004, respectively. In the S-180 solid tumor model, the inhibition of tumor growth was 29.45% and 50.50% for AR-A001 (120 mg/kg) and AR-A004 (110 mg/kg), respectively, compared to 50.18% for 5-fluorouracil (5-FU; 20 mg/kg). AR-A001 and AR-A004 were also significantly active in the leukemia model with 211.11% and 155.56% increase in mean survival time (MST) compared to a value of 211.11% for 5-FU. In conclusion, the ethanolic (AR-A001) and dichloromethane:methanol (AR-A004) root extracts of AR possess significant anticancer activities in vitro and in vivo.

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“…The decoction/infusion of the root of the plant is also used as an antidiabetic. 14 Antiinflammatory 15 and antitrypanosomal 16 activities of the plant have also been reported.…”

Section: Introductionmentioning

confidence: 94%

Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae)

Akindele

Wani

Mahajan

et al. 2015

Journal of Traditional and Complementary Medicine

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“…Bark, leaves and roots Angola, South Africa, Tanzania and Togo (Moshi et al, 2004;Kantati et al, 2016) Diabetes Leaves Angola, Côte d'Ivoire, Guinea and Nigeria (Olabanji et al, 2008;Göhre et al, 2016) Earache Fruits South Africa and Zimbabwe (Gelfand et al, 1985;Hutchings et al, 1996) Fever Leaves Togo (Koudouvo et al, 2011 Gastro-intestinal problems (diarrhoea, dysentery and stomach pains) Bark, leaves and roots Angola, Guinea-Bissau, Mali and Mozambique (Silva et al, 1996;Bruschi et al, 2011) Haemorrhoids Fruits Ethiopia (Yineger and Yewhalaw, 2007) Headache and migraine…”

Section: Convulsions and Epilepsymentioning

confidence: 99%

Gardenia ternifolia Schum. & Thonn. (Rubiaceae): Review of medicinal uses, phytochemistry and biological activities

Maroyi

2020

ijrps

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Gardenia ternifolia Schum. & Thonn. is a shrub or small tree widely used as a traditional medicine throughout its distributional range in tropical Africa. Gardenia ternifolia is widespread in tropical Africa, extending from Senegal eastwards to Ethiopia and Kenya, through the Democratic Republic of Congo (DRC) southwards to Namibia, South Africa and Mozambique. This study was aimed at providing a critical review of the medicinal uses, phytochemistry and biological activities of G. ternifolia. Documented information on the medicinal uses, phytochemistry and biological activities of G. ternifolia was collected from several online sources which included Scopus, Google Scholar, PubMed and Science Direct. Additional information was gathered from pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. This study showed that the species is widely used as an aphrodisiac and protective charm, and traditional medicine for headache, migraine, respiratory infections, sore eyes, hypertension, diabetes, gastro-intestinal problems, erectile dysfunction, malaria, convulsions and epilepsy. Phytochemical compounds identified from the species include alkaloids, anthocyanins, coumarins, flavonoids, phenols, quinones, saponins, steroids, stereoisomeric neolignans, tannins and terpenoids. Pharmacological research revealed that G. ternifolia extracts and compounds isolated from the species have antibacterial, antiviral, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, antisickling, antitheilerial, hepatotoxicity, larvicidal and cytotoxicity activities. Future research on G. ternifolia should focus on detailed phytochemical evaluations, including toxicological, in vivo and clinical studies to corroborate the traditional medical applications of the species.

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“…Its composition of magnesium, phosphorus, calcium, iron, zinc, copper and other elements have also been reported. 15 Clearly, A. ringens contains other useful phytochemicals that could be harnessed as lead compounds for drug development in the management of various disorders including primary hypertension. A pilot study carried out in our laboratory revealed that it reduces inotropic and chronotropic effects of an isolated rabbit heart and also induces vasomodulatory activity on isolated rat aortic ring.…”

Section: Introductionmentioning

confidence: 99%

Alterations of haemodynamic parameters in spontaneously hypertensive rats by A ristolochia ringens Vahl. (Aristolochiaceae)

Aigbe

Munavvar

Rathore

et al. 2018

Journal of Traditional and Complementary Medicine

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Aristolochia ringens Vahl. (Aristolochiaceae (AR); 馬兜鈴 mǎ dōu líng) is used traditionally in Nigeria for the management of various disorders including oedema. Preliminary investigation revealed its modulatory effect on the cardiovascular system. This study was aimed at investigating the effect of the aqueous root extract of A. ringens (AR) on haemodynamic parameters of spontaneously hypertensive rats (SHRs). The effect of oral subacute (21 days) and intravenous acute exposure of SHRs to the extract were assessed using tail cuff and carotid artery canulation methods respectively. In the latter, the effect of chloroform, butanol and aqueous fractions of AR were also evaluated. The extract significantly reduced systolic and diastolic blood pressures in SHRs, with peak reductions of 20.3% and 26.7% respectively at 50 mg/kg by the 21st day of oral subacute exposure. Upon intravenous exposure, AR (50 mg/kg) reduced systolic and diastolic blood pressure by as much as 53.4 ± 2.2 and 49.2 ± 2.8 mmHg respectively. A dose-dependent reduction in heart rate, significant at 25 and 50 mg/kg was also observed. Hexamethonium (20 mg/kg) and atropine (1 mg/kg) inhibited the extract's reduction of systolic blood pressure, diastolic blood pressure and heart rate significantly. The extract's butanol fraction produced the greatest systolic and diastolic blood pressures reduction of 67.0 ± 3.8 and 68.4 mmHg respectively at 25 mg/kg and heart rate reduction of 40 ± 7 beats per minute at 50 mg/kg. HPLC analysis revealed the presence of 4-hydroxybenzoic acid and quercetin in AR. The extract's alterations of haemodynamic parameters in this study show that it has hypotensive effect on spontaneously hypertensive rats.

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Accelerator-based analytical technique in the study of some anti-diabetic medicinal plants of Nigeria

Cited by 15 publications

References 4 publications

Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae)

Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae)

Gardenia ternifolia Schum. & Thonn. (Rubiaceae): Review of medicinal uses, phytochemistry and biological activities

Alterations of haemodynamic parameters in spontaneously hypertensive rats by A ristolochia ringens Vahl. (Aristolochiaceae)

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