Acceleration tests of a 3GHz proton linear accelerator (LIBO) for hadrontherapy

Martinis, C. De; Giove, D.; Amaldi, U.; Berra, P. Bruce; Crandall, K.R.; Mauri, M.; Weiss, M.; Zennaro, R.; Rosso, E.; Szeless, B.; Vretenar, M.; Masullo, M.R.; Vaccaro, V. G.; Calabretta, L.; Rovelli, A.

doi:10.1016/j.nima.2012.04.017

Cited by 26 publications

(18 citation statements)

References 7 publications

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“…The prototype device, which is composed of 9 coupled modules (1 module comprises 4 tanks, each of them consist of 13 accelerating cells), is able to increase the energy of protons extracted from a cyclotron from 62 MeV/u up to 200 MeV/u. 78,79 It is important that the energy of protons entering LIBO cannot be lower than 30 MeV/u, in order to avoid the decrease in the shunt impedance. However, the use of 15-MeV proton beams produced by small commercial cyclotrons will also be possible, thanks to the 1.5-GHz CLUSTER (Coupled-cavity Linac Using Transverse Electric Radial field).…”

Section: Tumour Trackingmentioning

confidence: 99%

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Kubiak¹

2016

BJR

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Particle therapy of moving targets is still a great challenge. The motion of organs situated in the thorax and abdomen strongly affects the precision of proton and carbon ion radiotherapy. The motion is responsible for not only the dislocation of the tumour but also the alterations in the internal density along the beam path, which influence the range of particle beams. Furthermore, in case of pencil beam scanning, there is an interference between the target movement and dynamic beam delivery. This review presents the strategies for tumour motion monitoring and moving target irradiation in the context of hadron therapy. Methods enabling the direct determination of tumour position (fluoroscopic imaging of implanted radio-opaque fiducial markers, electromagnetic detection of inserted transponders and ultrasonic tumour localization systems) are presented. Attention is also drawn to the techniques which use external surrogate motion for an indirect estimation of target displacement during irradiation. The role of respiratory-correlated CT [four-dimensional CT (4DCT)] in the determination of motion pattern prior to the particle treatment is also considered. An essential part of the article is the review of the main approaches to moving target irradiation in hadron therapy: gating, rescanning (repainting), gated rescanning and tumour tracking. The advantages, drawbacks and development trends of these methods are discussed. The new accelerators, called "cyclinacs", are presented, because their application to particle therapy will allow making a breakthrough in the 4D spot scanning treatment of moving organs.

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Section: Tumour Trackingmentioning

confidence: 99%

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Kubiak¹

2016

BJR

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“…The energy and the dose are at the threshold of clinical relevance. Acceleration to higher energies is possible using another stage such as the linac booster [47][48][49]. Supposing that these results can be confirmed in a single shot experiment, important technological developments are necessary to reach the 10 Hz maximum laser repetition rate in a stable and reliable way.…”

Section: Discussionmentioning

confidence: 99%

Transport and energy selection of laser generated protons for postacceleration with a compact linac

Sinigardi

Turchetti

Londrillo

et al. 2013

Phys. Rev. ST Accel. Beams

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Laser accelerated proton beams have a considerable potential for various applications including oncological therapy. However, the most consolidated target normal sheath acceleration regime based on irradiation of solid targets provides an exponential energy spectrum with a significant divergence. The low count number at the cutoff energy seriously limits at present its possible use. One realistic scenario for the near future is offered by hybrid schemes. The use of transport lines for collimation and energy selection has been considered. We present here a scheme based on a high field pulsed solenoid and collimators which allows one to select a beam suitable for injection at 30 MeV into a compact linac in order to double its energy while preserving a significant intensity. The results are based on a fully 3D simulation starting from laser acceleration.

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“…Linear accelerators (linacs) historically pre-date all the accelerator types mentioned so far [58], Wideroe having first proposed the concept in the 1920s to overcome the limitations of static voltages [83]. [84,85,86,87,88], and the TERA LIBO side-coupled structure has been adopted as the technology for the Advanced Oncotherapy (AVO) linacbased solution presently under construction at CERN. Similar to other applications of linacs one issue is about beam injection into such high-frequency structures.…”

Section: Linacsmentioning

confidence: 99%

Current and future accelerator technologies for charged particle therapy

Owen

Lomax

Jolly

2016

Nuclear Instruments and Methods in Physics Research Section A:

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The past few years have seen significant developments both of the technologies available for proton and other charged particle therapies, and of the number and spread of therapy centres. In this review we give an overview of these technology developments, and outline the principal challenges and opportunities we see as important in the next decade. Notable amongst these is the ever-increasing use of superconductivity both in particle sources and for treatment delivery, which is likely to greatly increase the accessibility of charged particle therapy treatments to hospital centres worldwide.

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Acceleration tests of a 3GHz proton linear accelerator (LIBO) for hadrontherapy

Cited by 26 publications

References 7 publications

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Particle therapy of moving targets—the strategies for tumour motion monitoring and moving targets irradiation

Transport and energy selection of laser generated protons for postacceleration with a compact linac

Current and future accelerator technologies for charged particle therapy

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