Acceleration of Wound Healing in Man With Zinc Sulphate Given by Mouth

Pories, W.J.; Henzel, J H; Rob, Charles; Strain, William H.

doi:10.1016/s0140-6736(67)91031-8

Cited by 262 publications

(88 citation statements)

References 8 publications

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“…In other countries, including the United States, there have been isolated reports of zinc deficiency complicating chronic illness [4] or malabsorption [27]. Pories et al [36] have shown that oral supplementation with zinc accelerates healing of wounds in surgical patients, and Sandstead et al [44] have demonstrated that, in the rat, a beneficial effect of such supplementation is observed only in the presence of a pre-existing zinc deficiency. Henkin and associates have reported recently that hypogeusia and dysgeusia are relatively common disorders in adults [15,19], and that these abnormalities of taste can frequently be corrected with oral therapy with zinc [15,16,19]; however, it is not known whether these patients had a pre-existing zinc deficiency [52].…”

Section: Introductionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

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ExtractConcentrations of zinc in hair were determined for 338 apparently normal subjects living in Denver with ages ranging from 0-40 years. Mean concentrations of zinc in hair were: neonates (25) 174 db 8 (1 SEM); 3 months^-years (93) 88 ± 5; 4-17 years (132) 153 ± 5, and 17^0 years (88) 180 ±4. Ten children more than 4 years of age had levels of zinc in hair of less than 70 ppm. Seven of these ten children had a history of poor appetite and eight had heights on or below the 10th percentile; the high incidence of low growth percentiles was not explicable on a familial basis. Taste acuity was tested in six of these children, and five had evidence of obj ective hypogeusia. After supplementing the diet with small quantities of zinc, taste acuity was normalized in each of these children and levels of zinc in hair increased. Speculation

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Section: Introductionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

View full text Add to dashboard Cite

show abstract

“…ZINC plays an important role in wound healing (Pories et al, 1967) and may also be concerned with the body's attempt to localize malignant disease. The latter possibility is suggested by the finding of elevated zinc concentrations in the uninvolved portions of liver invaded by metastases (Olson, Heggen and Edwards, 1958;Wright and Dormandy, 1973) or in liver tissue when a neoplasm is present elsewhere (Olson et al, 1958;Wright and Dormandy, 1973), and also by the inhibitory effect of oral zinc on the development of certain tumours in experimental animals (Poswilo and Cohen, 1971).…”

mentioning

confidence: 99%

Hepatic zinc concentrations in primary cancer of the liver

Kew¹,

Mallett²

1974

Br J Cancer

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“…6.2 days. Results of this study did not agree with those of other studies (Pories,, Henzel, Rob, & Strain, 1967). The reasons are not apparent, but it is suggested that either zinc sulfate is not a significant factor in the acceleration of wound healing or that neither study could be controlled sufficiently to cover all variations in individual patients.…”

Section: Zinccontrasting

confidence: 81%

“…Studies relating certain components of the diet (such as vitamins and zinc) in wound healing are varied. Some studies have reported no significance in the development of pressure ulcers (Barcia, 1970); while other studies have demonstrated beneficial effects in patients with slow healing of wounds (Gode and Burns, 1992;Pories, Henzel, Rob, & Strain, 1967). More rigorous studies are needed to further clarify these findings.…”

Section: Discussionmentioning

confidence: 99%

Pressure ulcers and nutritional deficits in elderly long-term care patients : effects of a comprehensive nutritional program on pressure ulcer healing, length of hospital stay and charges to patients

Allen¹

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Allen, Beverlin, "Pressure ulcers and nutritional deficits in elderly long-term care patients : effects of a comprehensive nutritional program on pressure ulcer healing, length of hospital stay and charges to patients" (2010 The dissertation of Beverlin Allen is approved. The elderly are at the highest risk of developing pressure ulcers that result in prolonged hospitalization, high health care costs, increased mortality, and decreased quality of life. The burden of pressure ulcers will intensify because of a rapidly increasing elderly population in the United States (US). Poor nutrition is a major predictor of pressure ulcer formation. The purpose of this study was to examine the effects of a comprehensive, interdisciplinary nutritional protocol on: 1) pressure ulcer wound healing 2) length of hospital stays, and 3) charges for pressure ulcer management. Interim Dean Sharon PontiusUsing a pre-intervention/post intervention quasi-experimental design the study sample was composed of 100 patients 60 years or older, admitted with or acquiring a pressure ulcer. A pre-intervention group (n= 50) received routine pressure ulcer care (standard diet, dressing changes, and equipment). A post-intervention group received routine care plus an interdisciplinary nutrition intervention (physical therapy, speech therapy, occupational therapy, added protein and calories to the diet). Research questions were vi analyzed using descriptive statistics, frequencies, Chi-Square Tests, and T-tests.

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Acceleration of Wound Healing in Man With Zinc Sulphate Given by Mouth

Cited by 262 publications

References 8 publications

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Hepatic zinc concentrations in primary cancer of the liver

Pressure ulcers and nutritional deficits in elderly long-term care patients : effects of a comprehensive nutritional program on pressure ulcer healing, length of hospital stay and charges to patients

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