Acceleration of Socket Healing by Using Placental Collagen with BDNF: Radiological and Histological Studies

Al-Hijazi, Athraa Y.; Al-Rifae, Imad K. Abbas; Akram, Zaid M.; Kaka, Luay N.

doi:10.5958/0976-5506.2019.01666.8

Cited by 2 publications

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“…The holes were treated with a combination of 0.5 microliter BMP2 (rhBMP-2, Medtronic Sofamor Danek, TN, USA) and 1 microliter BDNF (ab9794, Abcam, UK), dried gently and sutured. Determination of effective dose for BMP2/ BDNF depends on previous studies 15,16 .…”

Section: Induction Of Osteoporosismentioning

confidence: 99%

Association of Syndecan 4 and Osteocalcin with Application of BMP2 and BDNF in Bone Healing of Osteoporotic Rats

2020

MLU

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Background: Bone tissue contains multipotent stromal cells, which have the ability to differentiate into different specialized cells. Induced stem cells have been developed with various growth factors using many biomaterials, which are the most common strategiesin tissue engineering. Syndecan 4 and osteocalcin expressions during healing of bone defect in osteoporotic rat, along with the application of bone morphogenic protein 2 (BMP-2) and brain-derived neurotrophic factor (BDNF), were evaluated in this study. Method:Ten normal rats and 10 induced osteoporotic rats were used in this study. Three mm bone defects were created in the femur of each rat, one on the left side and another one on the right side. The left bone defects were left to heal spontaneously without any application, while the right ones were treated with a combination of BMP2 and BDNF. Immunohistochemical evaluation was done for positive expression of syndecan 4 and osteocalcin in bone tissue during healing periods.Results: Application of BMP2 and BDNF for both normal and osteoporotic rats increased the expressions of syndecan 4 and osteocalcin. In addition, expression of Syndecan 4 was decreased with increment period, while Osteocalcin expression showed the reverse. Statistical analysis revealed a significant difference regarding both positive expression of Syndecan 4 and osteocalcin in the treated groups compared to their untreated counterpart. Conclusion:Application of BMP-2 and BDNF enhances syndecan 4 and osteocalcin expressions in bone repair of osteoporotic rat.

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Section: Induction Of Osteoporosismentioning

confidence: 99%

Association of Syndecan 4 and Osteocalcin with Application of BMP2 and BDNF in Bone Healing of Osteoporotic Rats

2020

MLU

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Physiological and histological studies of dental response of Luxate tooth with application of VEGF

Al-khafaji

Faris²,

Al-Hijazi³

2022

ijhs

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Background During luxate injury many dental tissue will be involved including pulp, periodontal ligament ,mucosa, hard dental tissue and alveolar bone with affecting the nerve and dental blood supplement. Growth factors may involved in healing process after replantation of tooth in its socket and the Vascular endothelial factor (VEGF ) is a potent one that increase angiogenesis and accelerate repairing and healing of dental pulp and the supporting tissues. The study was designed to illustrate the effect of application of growth factor on healing process of luxate molar tooth of rat. Materials & Methods Twenty male Wistar rats with luxate lower right first molar teeth were included in this study. The control were injected with normal saline (0.5μl ) around the apex of mesial root .Experimental group injected with VEGF (0.5μl ). Histological assessment of physiological responses of (dental pulp, cementum, periodontal ligament (PDL) and alveolar bone in both control and experimental groups with Receptor activator of nuclear factor kappa-Β ligand (RANKL) expression evaluation were recorded during the healing period in the examined tissue.

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Acceleration of Socket Healing by Using Placental Collagen with BDNF: Radiological and Histological Studies

Cited by 2 publications

References 0 publications

Association of Syndecan 4 and Osteocalcin with Application of BMP2 and BDNF in Bone Healing of Osteoporotic Rats

Association of Syndecan 4 and Osteocalcin with Application of BMP2 and BDNF in Bone Healing of Osteoporotic Rats

Physiological and histological studies of dental response of Luxate tooth with application of VEGF

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