Acceleration of skin wound healing by low‐dose indirect ionizing radiation in male rats

Jabbari, Nasrollah; Farjah, Gholam Hossein; Ghadimi, Behnam; Zanjani, Hajar; Heshmatian, Behnam

doi:10.1016/j.kjms.2017.05.013

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…23,24 More recent studies have reported an accelerated healing of bone fractures with single doses (0.5 Gy) of X-rays in male Sprague-Dawley rats. 32 Similarly, Jabbari et al 33 reported that a single dose of γ-rays (0.75 Gy) immediately after surgery significantly accelerated the healing process for a full-thickness wound in male Sprague-Dawley rats. Supporting this possibility was an experimental study by Kataoka et al 34 in which a single 0.25 Gy exposure significantly enhanced liver catalase activity in adult mice 24 h after exposure.…”

Section: Resultsmentioning

confidence: 98%

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

et al. 2019

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During the early part of the past century, hundreds of clinical studies involving more than 37,000 patients were conducted that showed radiotherapy (RT) to be a successful and safe alternative to drug therapy for the treatment of many diverse inflammatory conditions and diseases (e.g. tendonitis, bursitis, arthritis, and serious inflammatory lung conditions). Data from these studies were collected and analyzed with the intent of estimating an optimal dosing range for RT that would induce an efficacious treatment response. RT was reported to be frequently effective after only a single treatment, with a rapid (within 24 h) and often long-lasting (from months to years) relief from symptoms. Over a two-decade span from the 1920s to the 1940s, the therapeutic responses to a single RT treatment consistently improved as the dosing for multiple ailments decreased over time to between 30 roentgen (r) and 100 r. These findings are significant and in agreement with a number of contemporary reports from Germany where RT has been commonly and successfully employed in treating ailments with an inflammatory origin. A proposed mechanism by which RT mitigates inflammation and facilitates healing is via the polarization of macrophages to an anti-inflammatory or M2 phenotype.

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Section: Resultsmentioning

confidence: 98%

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

et al. 2019

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“…The relationship between low doses of radiation and wound healing, however, is not straightforward. Depending on factors such as the duration of exposure, the severity of the wound, and the individual’s overall health, low doses of radiation could either positively or negatively affect wound healing [ 21 , 82 , 83 , 84 ]. The findings from this study in HMEC-1, a group of human dermal microvascular ECs, may encourage further research to investigate the effects of acute exposure to low doses of radiation on angiogenesis in wounds and the healing process.…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Effects of Radiation on Mitochondrial Morphology and Clonogenic Cell Survival in Human Microvascular Endothelial Cells

Wang,

Rivas,

Wilson

et al. 2023

Cells

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To better understand radiation-induced organ dysfunction at both high and low doses, it is critical to understand how endothelial cells (ECs) respond to radiation. The impact of irradiation (IR) on ECs varies depending on the dose administered. High doses can directly damage ECs, leading to EC impairment. In contrast, the effects of low doses on ECs are subtle but more complex. Low doses in this study refer to radiation exposure levels that are below those that cause immediate and necrotic damage. Mitochondria are the primary cellular components affected by IR, and this study explored their role in determining the effect of radiation on microvascular endothelial cells. Human dermal microvascular ECs (HMEC-1) were exposed to varying IR doses ranging from 0.1 Gy to 8 Gy (~0.4 Gy/min) in the AFRRI 60-Cobalt facility. Results indicated that high doses led to a dose-dependent reduction in cell survival, which can be attributed to factors such as DNA damage, oxidative stress, cell senescence, and mitochondrial dysfunction. However, low doses induced a small but significant increase in cell survival, and this was achieved without detectable DNA damage, oxidative stress, cell senescence, or mitochondrial dysfunction in HMEC-1. Moreover, the mitochondrial morphology was assessed, revealing that all doses increased the percentage of elongated mitochondria, with low doses (0.25 Gy and 0.5 Gy) having a greater effect than high doses. However, only high doses caused an increase in mitochondrial fragmentation/swelling. The study further revealed that low doses induced mitochondrial elongation, likely via an increase in mitochondrial fusion protein 1 (Mfn1), while high doses caused mitochondrial fragmentation via a decrease in optic atrophy protein 1 (Opa1). In conclusion, the study suggests, for the first time, that changes in mitochondrial morphology are likely involved in the mechanism for the radiation dose-dependent effect on the survival of microvascular endothelial cells. This research, by delineating the specific mechanisms through which radiation affects endothelial cells, offers invaluable insights into the potential impact of radiation exposure on cardiovascular health.

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“…Recent studies revealed that tissue repairing might be enhanced by low dose irradiation through up-regulation of the level of VEGF (12). Jabbari concluded that gamma-ray irradiation is effective for the acceleration of wound healing (13). However, there is no basic or clinical research of low-dose radiation in the treatment of pressure ulcer.…”

Section: Discussionmentioning

confidence: 99%

Low-dose Radiotherapy for Unstageable Pressure Ulcer:A Case Report

Lin¹,

Mao²,

Guan³

et al. 2021

Preprint

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Background：Pressure ulcer is a common complication of long-term bedridden patients, but current treatment strategies have limited efficacy for pressure ulcer. Case presentation：We present a 17-year-old man with unstageable pressure ulcer treated with three-dimensional conformal radiotherapy. We irradiate the posterior lumbosacral pressure ulcer with 3D-CRT using a 6 MV photon beam. The patient was placed in a prone position and a total dose of 50cGy was administered. Then, the healing was evaluated using PUSH scale score on days 8，12 and 3 months after radiotherapy. After radiotherapy, beefy red tissue with a shiny, moist, granular appearance tissue are present in the wound bed, exudate amount was decreased, the depth of the pressure ulcer became significantly shallower and the wound surface area was reduced. PUSH scale score descreased from15 to 7.Conclusion: Radiotherapy could be a promising treatment strategy of unstageable pressure ulcer.

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Acceleration of skin wound healing by low‐dose indirect ionizing radiation in male rats

Cited by 10 publications

References 26 publications

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

Dose-Dependent Effects of Radiation on Mitochondrial Morphology and Clonogenic Cell Survival in Human Microvascular Endothelial Cells

Low-dose Radiotherapy for Unstageable Pressure Ulcer:A Case Report

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