Acceleration of Primary Wound Healing by Insulin

Rosenthal, Stoyan P.

doi:10.1001/archsurg.1968.01330190055012

Cited by 47 publications

(37 citation statements)

References 6 publications

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“…Since control of blood glucose levels have been shown to improve wound healing in diabetics, 37 it is quite possible that the enhanced healing of wounds in diabetic rats by oral administration of MC flower extract is the result of its hypoglycemic activity that has been demonstrated in a previous study. 38 Furthermore, wounds in diabetics have a higher propensity to become infected, which may impede the progress or completion of healing.…”

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confidence: 90%

The wound healing property of ethanolic extract of <i>Michelia champaca</i> flowers in diabetic rats

Gowda

Shanbhag

Bangalore

et al. 2014

Int J Basic Clin Pharmacol

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confidence: 90%

The wound healing property of ethanolic extract of <i>Michelia champaca</i> flowers in diabetic rats

Gowda

Shanbhag

Bangalore

et al. 2014

Int J Basic Clin Pharmacol

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“…Previous reports have indicated that wound healing capacity is markedly decreased in human and animal models of diabetes [1][2][3][4][5][6][7][8][9]. In this context, Goodson and Hunt documented deficiencies in the inflammatory and proliferative phases of wound healing in poorly controlled diabetic patients [3].…”

Section: Figmentioning

confidence: 99%

“…This phenomenon constitutes a serious problem for surgical incision and decubitus ulcer outcome in diabetic patients. Studies in human and animal models of diabetes have revealed abnormalities in the various phases of the wound healing process including inflammation, collagen deposition and differentiation of the extracellular matrix, fibroplasia, and contraction of open wounds [1][2][3][4][5]. In addition, skin tensile strength and the levels of growth-promoting polypeptides including insulin like growth factor 1 (IGF-1) and transforming growth factor ␤ (TGF-␤) in the wound environment are also altered as a function of diabetes [6 -9].…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid-Dependent Impairment of Wound Healing in Experimental Diabetes: Amelioration by Adrenalectomy and RU 486

Bitar¹,

Thameem²,

Wahid³

et al. 1999

Journal of Surgical Research

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“…The effect of insulin on muscle protein has been investigated extensively in the normal state (2, 6, 7, 9, 11-13, 18, 21) and also in catabolic states such as after severe burns (5,17). However, although the general role of insulin in wound healing is well known (10,14,16), the effect of insulin on protein metabolism in skin wound has not been assessed sufficiently.…”

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confidence: 99%

Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids

Zhang

Chinkes

Irtun

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

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Zhang, Xiao-Jun, David L. Chinkes, Øivind Irtun, and Robert R. Wolfe. Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids. Am J Physiol Endocrinol Metab 282: E1308-E1315, 2002; 10.1152/ ajpendo.00361.2001.-To investigate the metabolic basis of skin wound healing, we measured in anesthetized rabbits the responses of protein kinetics in scalded skin to insulin and amino acids. L-[ring-13 C6]Phe was infused on the 7th day after the ear was scalded, and the scalded ear was used as an arteriovenous unit to reflect protein kinetics in skin wound. The ipsilateral carotid artery was clamped to control the wound blood flow within four-to fivefold the normal skin rate to measure the enrichment difference in the scalded ear during hyperaminoacidemia. Neither insulin (2.5 mU ⅐ kg Ϫ1 ⅐ min Ϫ1 ) nor amino acid (2.5 mg ⅐ kg Ϫ1 ⅐ min Ϫ1 ) infusion alone improved net protein balance in the skin wound. In contrast, combined infusion of insulin and amino acids increased the net protein balance in skin wound from Ϫ6.5 Ϯ 4.5 to 1.4 Ϯ 5.2 mol ⅐ 100 g Ϫ1 ⅐ h Ϫ1 (P Ͻ 0.01, control vs. insulin plus amino acids). We conclude that there is an interactive effect of insulin and sufficient amino acid supply on protein metabolism in skin wound, meaning that their combined anabolic effect is greater than the sum of their individual effects. stable isotopes; gas chromatograph-mass spectrometer; rabbit ear; arteriovenous balance INSULIN IS A KEY ANABOLIC HORMONE and not only plays an important role in substrate metabolism but also is a regulator of protein synthesis and breakdown. The effect of insulin on muscle protein has been investigated extensively in the normal state (2, 6, 7, 9, 11-13, 18, 21) and also in catabolic states such as after severe burns (5, 17). However, although the general role of insulin in wound healing is well known (10, 14, 16), the effect of insulin on protein metabolism in skin wound has not been assessed sufficiently.The lack of information regarding the effect of insulin on protein metabolism in skin wound is largely because of the lack of a method to quantify both protein synthesis and breakdown in vivo. To this end, we developed a rabbit ear model for measurement of protein metabolism in skin wound (24,26). Using this animal model, we demonstrated in our previous experiment (24) that insulin had an anabolic effect on wound protein resulting from the inhibition of protein breakdown. It is possible that the failure of insulin to stimulate protein synthesis was because of an insufficient supply of amino acids (AAs). Although AAs were infused during the insulin infusion, the plasma AA concentrations were only maintained at levels that were either comparable to the postabsorptive state (during insulin infusion at 0.6 mU ⅐ kg Ϫ1 ⅐ min Ϫ1) or even lower (during insulin infusion at 2.3-3.4 mU ⅐ kg Ϫ1 ⅐ min Ϫ1). Consequently, the potential role of sufficient AA supply in conjunction with insulin on wound protein metabolism is not clear.The present study was designed to investigate the p...

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Acceleration of Primary Wound Healing by Insulin

Cited by 47 publications

References 6 publications

The wound healing property of ethanolic extract of <i>Michelia champaca</i> flowers in diabetic rats

The wound healing property of ethanolic extract of <i>Michelia champaca</i> flowers in diabetic rats

Glucocorticoid-Dependent Impairment of Wound Healing in Experimental Diabetes: Amelioration by Adrenalectomy and RU 486

Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids

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Acceleration of Primary Wound Healing by Insulin

Cited by 47 publications

References 6 publications

The wound healing property of ethanolic extract of &lt;i&gt;Michelia champaca&lt;/i&gt; flowers in diabetic rats

The wound healing property of ethanolic extract of &lt;i&gt;Michelia champaca&lt;/i&gt; flowers in diabetic rats

Glucocorticoid-Dependent Impairment of Wound Healing in Experimental Diabetes: Amelioration by Adrenalectomy and RU 486

Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids

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The wound healing property of ethanolic extract of <i>Michelia champaca</i> flowers in diabetic rats

The wound healing property of ethanolic extract of <i>Michelia champaca</i> flowers in diabetic rats