Purpose
To develop a compressed sensing (CS) acceleration method with a high spectral bandwidth exploiting the spatial-spectral sparsity of MR spectroscopic imaging (MRSI).
Methods
Accelerations were achieved using blip gradients during the readout to perform non-overlapped and stochastically delayed random walks in kx-ky-t space, combined with block-Hankel matrix completion for efficient reconstruction. Both retrospective and prospective CS accelerations were applied to 13C MRSI experiments, including in vivo rodent brain and liver studies with administrations of hyperpolarized [1-13C] pyruvate at 7T and [2-13C] dihydroxyacetone at 3T, respectively.
Results
In retrospective undersampling experiments using in vivo 7T data, the proposed method preserved spectral, spatial and dynamic fidelities with R2 ≥ 0.96 and ≥ 0.87 for pyruvate and lactate signals, respectively, 750-Hz spectral separation and up to 6.6-fold accelerations. In prospective in vivo experiments, with 3.8-fold acceleration, the proposed method exhibited excellent spatial localization of metabolites and peak recovery for pyruvate and lactate at 7T as well as for dihydroxyacetone and its metabolic products with a 4.5-kHz spectral span (140 ppm at 3T).
Conclusion
This study demonstrated the feasibility of a new CS approach to accelerate high spectral bandwidth MRSI experiments.