Accelerating worldwide syphilis screening through rapid testing: a systematic review

Incidência de sífilis congênita e fatores associados à transmissão vertical da sífilis: dados do estudo Nascer no Brasil

“…Testes rápidos treponêmicos apresentam sensibilidade e especificidade semelhantes aos de testes treponêmicos realizados em laboratório 27 . Sua sensibilidade e especificidade foram comparáveis às de testes não treponêmi-cos utilizados na testagem de rotina realizada em clínicas de DST ou em serviços de pré-natal 28 . Sua utilização em locais com recursos limitados na África Subsaariana mostrou-se altamente custo-efetiva, mesmo se ocorrer redução da prevalência de sífilis na gestação 29 .…”

Assessment of the impact of rapid syphilis tests on syphilis screening and treatment of pregnant women in Zambia

“…Recently-developed rapid syphilis tests (RST; BIOLINE, Korea) have a high sensitivity (85.7% to 100%) and specificity (96% to 100%), and do not require the traditional laboratory infrastructure used for rapid plasma reagin (RPR) tests [7][8][9]. Previous studies have suggested increased syphilis screening post-RST implementation, but longerterm evaluation of screening rates after initial training is needed [10].…”

“…Treatment of syphilis-seroreactive pregnant women with 1 dose of intramuscular penicillin at least 30 days prior to delivery reduces the risk of adverse pregnancy outcomes to that of a non-infected mother, although full treatment of latent maternal syphilis requires three doses of intramuscular penicillin [3][4][5]. However, modeling data suggest that less than 10% of women with syphilis during pregnancy are screened and appropriately treated [1], despite the 2007 World Health Organization's Global Elimination of Congenital Syphilis initiative goals of testing more than 90% of pregnant women and of treating more than 90% of those who are seroreactive by 2015 [6].Recently-developed rapid syphilis tests (RST; BIOLINE, Korea) have a high sensitivity (85.7% to 100%) and specificity (96% to 100%), and do not require the traditional laboratory infrastructure used for rapid plasma reagin (RPR) tests [7][8][9]. Previous studies have suggested increased syphilis screening post-RST implementation, but longerterm evaluation of screening rates after initial training is needed [10].…”

Scaling up syphilis testing in China: implementation beyond the clinic

“…3 Although validated point-of-care syphilis tests are available at prices negotiated by the World Health Organization (WHO), successful pilot programmes have been implemented in high burden areas, and policy latitude for screening and scale-up already exist, routine syphilis screening has not been widely implemented in China. 4 Public health authorities keep records of syphilis testing and treatment since syphilis cases cluster and re-infection rates are high. 5 Coordination of clinical and public health functions is no small task, and this is why developing rationale syphilis policy is very important.…”