Accelerating the development of implantable neurochemical biosensors by using existing clinically applied depth electrodes

MacDonald, Alexander; Charlton, Francessca; Corrigan, Damion K.

doi:10.1007/s00216-022-04445-1

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Thus, enormous efforts have been dedicated towards the design and development of novel electrochemical biosensors, due to which significant advances have recently taken place in the field of electrochemical biosensing, aptasensing, and immunosensing. Furthermore, electrochemical-based technologies such as wearables, continuous monitoring devices, implants, chips, and microfluidic devices are being developed [ 169 , 170 , 171 , 172 , 173 , 174 ]. Thus, we sought to write a summarized review of the recent advancements in the design and fabrication of electrochemical biosensor platforms using various tailor-made functional materials, molecules, and their sensible hybrids.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces.

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Section: Summary and Future Perspectivesmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Recent Progress and Challenges of Implantable Biodegradable Biosensors

Alam,

Ashfaq Ahmed,

Jalal

et al. 2024

Micromachines

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Implantable biosensors have evolved to the cutting-edge technology of personalized health care and provide promise for future directions in precision medicine. This is the reason why these devices stand to revolutionize our approach to health and disease management and offer insights into our bodily functions in ways that have never been possible before. This review article tries to delve into the important developments, new materials, and multifarious applications of these biosensors, along with a frank discussion on the challenges that the devices will face in their clinical deployment. In addition, techniques that have been employed for the improvement of the sensitivity and specificity of the biosensors alike are focused on in this article, like new biomarkers and advanced computational and data communicational models. A significant challenge of miniaturized in situ implants is that they need to be removed after serving their purpose. Surgical expulsion provokes discomfort to patients, potentially leading to post-operative complications. Therefore, the biodegradability of implants is an alternative method for removal through natural biological processes. This includes biocompatible materials to develop sensors that remain in the body over longer periods with a much-reduced immune response and better device longevity. However, the biodegradability of implantable sensors is still in its infancy compared to conventional non-biodegradable ones. Sensor design, morphology, fabrication, power, electronics, and data transmission all play a pivotal role in developing medically approved implantable biodegradable biosensors. Advanced material science and nanotechnology extended the capacity of different research groups to implement novel courses of action to design implantable and biodegradable sensor components. But the actualization of such potential for the transformative nature of the health sector, in the first place, will have to surmount the challenges related to biofouling, managing power, guaranteeing data security, and meeting today’s rules and regulations. Solving these problems will, therefore, not only enhance the performance and reliability of implantable biodegradable biosensors but also facilitate the translation of laboratory development into clinics, serving patients worldwide in their better disease management and personalized therapeutic interventions.

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Accelerating the development of implantable neurochemical biosensors by using existing clinically applied depth electrodes

Cited by 2 publications

References 34 publications

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Recent Progress and Challenges of Implantable Biodegradable Biosensors

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