Accelerating recovery from acute hemarthrosis in patients with hemophilia

Corte‐Rodríguez, Hortensia De la; Rodríguez-Merchán, E. Carlos; Álvarez‐Román, María Teresa; Martín‐Salces, Mónica; Romero-Garrido, José Antonio; Jiménez‐Yuste, Víctor

doi:10.1097/mbc.0000000000000803

Cited by 30 publications

(26 citation statements)

References 34 publications

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“…A very recent article by De la Corte-Rodríguez et al . showed that arthrocentesis carried out immediately after the diagnosis of acute hemarthrosis in strictly aseptic conditions and under hemostatic coverage was well tolerated and accelerated joint recovery 72 . Lastly, Rezende et al .…”

Section: A New Wave In the Evaluation Of Hemophilic Arthropathymentioning

confidence: 99%

Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia

Bakeer

Shapiro

2019

F1000Res

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Bleeding with resultant hemophilic arthropathy constitutes the largest cause of morbidity in patients with hemophilia. It results from repeated bleeding episodes in the joint and is characterized by synovial hypertrophy and cartilage and bony destruction. Hemophilic arthropathy assessment is a continually evolving process and is particularly challenging in children and young adults in whom joint disease may be missed or underestimated as obtaining serial “baseline” magnetic resonance imaging scans of multiple clinically asymptomatic or nearly asymptomatic joints may be unjustifiable and cost-ineffective. Musculoskeletal ultrasound—particularly, point-of-care musculoskeletal ultrasound—has emerged as a promising imaging modality for the early detection and management of hemophilic arthropathy, and for the evaluation of hemarthrosis and painful musculoskeletal episodes in patients with hemophilia. This review summarizes currently available data on the emerging role of this new imaging modality, its limitations, and gaps in knowledge. The review also raises unanswered questions, highlights the need for consolidated research efforts, and delineates future directions expected to advance this technology and optimize its use in this patient population.

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Section: A New Wave In the Evaluation Of Hemophilic Arthropathymentioning

confidence: 99%

Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia

Bakeer

Shapiro

2019

F1000Res

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“…In acute hemarthroses treatment should be administered intensively, therapy named enhanced on-demand treatment, until the resolution of symptoms. Ultrasonography is a Propper diagnostic technique to assess the evolution of acute hemarthrosis in hemophilia (90,91).…”

Section: Surgical Interventions For the Hemophilic Patientmentioning

confidence: 99%

“…Arthrocentesis must be carried out immediately after diagnosis of acute hemarthrosis in liquid phase. Patients must be infused with the deficient coagulation factor and instructed to observe relative rest until resolution of hemarthrosis (91).…”

Section: Surgical Interventions For the Hemophilic Patientmentioning

confidence: 99%

Current therapeutic approaches in the management of hemophilia—a consensus view by the Romanian Society of Hematology

et al. 2021

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Hemophilia A (HA) and hemophilia B (HB) are rare disorders, being caused by the total lack or under-expression of two factors from the coagulation cascade coded by genes of the X chromosome. Thus, in hemophilic patients, the blood does not clot properly. This results in spontaneous bleeding episodes after an injury or surgical intervention. A patient-centered regimen is considered optimal. Age, pharmacokinetics, bleeding phenotype, joint status, adherence, physical activity, personal goals are all factors that should be considered when individualizing therapy. In the past 10 years, many innovations in the diagnostic and treatment options were presented as being either approved or in development, thus helping clinicians to improve the standard-of-care for patients with hemophilia. Recombinant factors still remain the standard of care in hemophilia, however they pose a challenge to treatment adherence because they have short halflife, which where the extended half-life (EHL) factors come with the solution, increasing the half-life to 96 hours. Gene therapies have a promising future with proven beneficial effects in clinical trials. We present and critically analyze in the current manuscript the pros and cons of all the major discoveries in the diagnosis and treatment of HA and HB, as well as identify key areas of hemophilia research where improvements are needed.

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“…Because arthrocentesis can lessen the deposition of damaging blood products within the joint cartilage and synovium; therefore, it could be accelerating resolution of joint bleeds as well as reducing the number of days of pain and decreased joint ROM, and the number of days away from school/work for HB patients who have a painful and tense haemarthrosis or suspicion of infection. Besides, the literature on haemophilia regards arthrocentesis as a well‐tolerated associated with a minimum rebleeding and infections risk in the short‐ or the medium‐/long‐term under cover of deficient factor and in aseptic conditions 4 …”

Section: Figurementioning

confidence: 99%

A rare case of long‐term complications of squamous cell carcinoma in haemophilia B after arthrocentesis, and review of the literature

Liu

Tong

et al. 2021

Haemophilia

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Accelerating recovery from acute hemarthrosis in patients with hemophilia

Cited by 30 publications

References 34 publications

Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia

Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia

Current therapeutic approaches in the management of hemophilia—a consensus view by the Romanian Society of Hematology

A rare case of long‐term complications of squamous cell carcinoma in haemophilia B after arthrocentesis, and review of the literature

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