Accelerating neovascularization and kidney tissue formation with a 3D vascular scaffold capturing native vascular structure

Min, Sang Il; Cleveland, D E; Ko, In Kap; Kim, Ji Hyun; Yang, Hee Jo; Atala, Anthony; Yoo, James J.

doi:10.1016/j.actbio.2021.01.040

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…The natural vascular wall is considered to be the best anticoagulation surface, with the endothelium playing an important role. − The endothelium synthesizes and secretes a variety of bioactive substances, ,, which regulate blood pressure and maintain the balance of coagulation and anticoagulation while maintaining normal blood flow and long-term vascular patency. − …”

Section: Resultsmentioning

confidence: 99%

Artificial Extracellular Matrix Composed of Heparin-Mimicking Polymers for Efficient Anticoagulation and Promotion of Endothelial Cell Proliferation

Wang

Wang²,

Feng

et al. 2022

ACS Appl. Mater. Interfaces

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Heparin-mimicking polymers have emerged as an alternative to heparin to construct effective and safe anticoagulant surfaces. However, the present heparin-mimicking polymers are usually limited to the combinations of glucose and sulfonic acid units, and the structure origin of their anticoagulant properties remains vague. Inspired by the structure of natural heparin, we synthesized a series of novel heparin-mimicking polymers (named GSAs) composed of three units, glucose, sulfonic acid, and carboxylic acid. Then, we constructed artificial extracellular matrices composed of GSAs and two typical cationic polymers, polyethyleneimine and chitosan, to investigate the anticoagulation and endothelialization of GSAs. By changing the ratio of the three units, their functions in the matrices were studied systematically. We found that an increase in the sulfonic acid content enhanced surface anticoagulant activity, an increase in glucose and sulfonic acid content promoted the proliferation of human umbilical vein vascular endothelial cells, and an increase in the carboxylic acid content inhibited the adherence of human umbilical vein vascular smooth muscle cells. This work uncovers the important role of the GSAs structure to the anticoagulation properties, which sheds new light on the design and preparation of heparin-mimicking polymers for practical engineering applications.

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Section: Resultsmentioning

confidence: 99%

Artificial Extracellular Matrix Composed of Heparin-Mimicking Polymers for Efficient Anticoagulation and Promotion of Endothelial Cell Proliferation

Wang

Wang²,

Feng

et al. 2022

ACS Appl. Mater. Interfaces

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show abstract

“…138,139 The surface of the material is loaded with VEGF in the form of physical coating or electrostatic deposition for orderly release in the body, which can significantly improve the in-situ endothelialization ability of the vascular implant material. 140,141 Min et al 142 used collagen to construct biomimetic renal vascular 3D stent, and then VEGF is introduced into the surface of the material by grafting heparin on the stent to prepare a vascular implant material with VEGF controlled release ability. Due to the short half-life of VEGF in the blood environment, early burst release can increase the content of VEGF in the environment, so as to achieve rapid endothelialization.…”

Section: Surface Design Based On Biological Function Intervention And...mentioning

confidence: 99%

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

Bian

Chen

Weng

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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In recent years, more and more metal or non-metal materials have been used in the treatment of cardiovascular diseases, but the vascular complications after transplantation are still the main factors restricting the clinical application of most grafts, such as acute thrombosis and graft restenosis. Implant materials have been extensively designed and surface optimized by researchers, but it is still too difficult to avoid complications. Natural vascular endodermis has excellent function, anti-coagulant and anti-intimal hyperplasia, and it is also the key to maintaining the homeostasis of normal vascular microenvironment. Therefore, how to promote the adhesion of endothelial cells (ECs) on the surface of cardiovascular materials to achieve endothelialization of the surface is the key to overcoming the complications after implant materialization. At present, the surface endothelialization design of materials based on materials surface science, bioactive molecules, and biological function intervention and feedback has attracted much attention. In this review, we summarize the related research on the surface modification of materials by endothelialization in recent years, and analyze the advantages and challenges of current endothelialization design ideas, explain the relationship between materials, cells, and vascular remodeling in order to find a more ideal endothelialization surface modification strategy for future researchers to meet the requirements of clinical biocompatibility of cardiovascular materials.

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“…Furthermore, considering the renal tissue is a highly vascularized tissue, angiogenesis may play a crucial role in renal injury repair and regeneration. Although previous studies have shown that the vascularization of renal tissue engineering scaffolds after implantation in vivo contribute to the repair and regeneration of renal injury [ 9 , 10 ], how to efficiently induce and promote the in-situ vascularization or angiogenesis is challenging yet critical for the repair and regeneration of damaged kidneys [ 13 , 14 ]. An ideal tissue-engineered scaffold needs to respond effectively to local damage microenvironments for maximum effectiveness.…”

Section: Introductionmentioning

confidence: 99%

3D hypoxia-mimicking and anti-synechia hydrogel enabling promoted neovascularization for renal injury repair and regeneration

Zhang

Qiu

et al. 2023

Materials Today Bio

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Accelerating neovascularization and kidney tissue formation with a 3D vascular scaffold capturing native vascular structure

Cited by 7 publications

References 32 publications

Artificial Extracellular Matrix Composed of Heparin-Mimicking Polymers for Efficient Anticoagulation and Promotion of Endothelial Cell Proliferation

Artificial Extracellular Matrix Composed of Heparin-Mimicking Polymers for Efficient Anticoagulation and Promotion of Endothelial Cell Proliferation

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

3D hypoxia-mimicking and anti-synechia hydrogel enabling promoted neovascularization for renal injury repair and regeneration

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