Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex

Polyelectrolyte complex materials from chitosan and gellan gum

“…Chitosan-alginate 95,295 , chitosan-carrageenan 149 and chitosan-heparin 160 are mixable by stirring and the resulting solution can be cast into films. In contrast, chitosan (CH) and gellan gum (GG) solutions are unable to be mixed together due to insoluble gellan gum in acidic medium.…”

“…Many studies have been devoted to the preparation of wound dressing from polysaccharides based polyelectrolyte complex (PEC) techniques 95,310,[364][365][366] .…”

Novel Chitin and Chitosan Materials in Wound Dressing

“…In smad3 ASOs-polyelectrolyte complex, the healing process suggested by wound closure and histological observation was faster than other groups because collagen contents increased and level of TGF-b1 decreased. These results demonstrate that the smad3 ASOs-polyelectrolyte complex composed of chitosan and sodium alginate scaffold could be applied for accelerated wound healing (Hong et al, 2008). The gold colloid/chitosan film scaffold, accelerate proliferation of newborn mice keratinocytes, was fabricated by self-assembly technology (Zhang et al, 2009).…”

“…Smad3 mediates the intracellular signaling of TGF-b1 superfamily and plays a critical role in the cellular proliferation, differentiation and elaboration of matrix pivotal to cutaneous wound healing. Smad3 antisense oligonucleotides (ASOs) impregnated polyelectrolyte complex scaffold containing chitosan and sodium alginate was prepared for accelerated wound healing (Hong et al, 2008). Physicochemical properties of polyelectrolyte complex were characterized by zeta potential, SEM and bioadhesive test.…”

In VivoPerformance of Chitosan/Soy-Based Membranes as Wound-Dressing Devices for Acute Skin Wounds

“…Among the many different animal models to study wound healing and skin regeneration, excision of rat skin portions is a model widely used. 8,17,22,[40][41][42][43][44][45] Therefore, a wound-dressing rat model of partial-thickness skin wound, under impaired healing conditions, was used to assess the suitability of the cht/soy membranes to promote wound healing. Comparatively, Epigard Ò , a clinically accepted wound dresser, was used as control.…”