Accelerated Transport of a-Aminoisobutyric Acid in Kidney During Compensatory Hypertrophy

Ross, Jeffrey S.; Vancura, P; Malt, Ronald A.

doi:10.3181/00379727-142-37082

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…indicating that protein synthesis is required for stimulated transport. An increased uptake of AlB is also aso sociated with compensatory growth of muscle (Goldberg 1971) and kidney (Ross, Vancura and Malt 1973). In some systems, inhibition of growth by cyc- 1972;Blat, Baix and Hasel 1973).…”

Section: Introductionmentioning

confidence: 99%

Cyclic AMP Mediated Increased Amino Acid Transport: Effect of Isoproterenol Administration

Malamud¹,

Chiu

1978

Horm Metab Res

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A single injection of isoproterenol (IPR) stimulates cell proliferation in rodent salivary glands after a lag period of about 24 hrs. Among the many events occurring prior to stimulated DNA synthesis, there is an early increase in cAMP levels and elevated transport of amino acids into the parotid gland. Amino acid transport is also elevated in liver and pancreas, tissues not induced to proliferate by IPR. IPR-stimulated alpha-aminoisobutyric acid (AIB) transport in parotid, pancreas and liver is augmented by prior injection of theophylline and is mimicked by dibutyryl cAMP. In all three tissues, changes in cAMP levels and subsequent increases in AIB transport appear to be closely related events. Since only the parotid gland is stimulated to grow after IPR injection, amino acid transport and growth would not appear to be directly related.

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Section: Introductionmentioning

confidence: 99%

Cyclic AMP Mediated Increased Amino Acid Transport: Effect of Isoproterenol Administration

Malamud¹,

Chiu

1978

Horm Metab Res

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Renal Growth Factor

Malt¹

1973

Humoral Control of Growth and Differentiation

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Humoral factors in regulation of compensatory renal hypertrophy

Malt

1983

Kidney International

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Compensatory renal hypertrophy in transplanted kidneys shows that the major regulators are humoral. Crosscirculation experiments are confirmatory indicating further that the regulators are short-lived and must be consistently present during the early phases of hypertrophy. Controls are difficult to achieve in other systems; variables relate to nutrition, means of assay, pharmacokinetics, and abnormalities produced by the experimental model itself. A simple hypothesis to account for the events precipitating renal hypertrophy might integrate the onsets of renal hyperemia soon after contralateral nephrectomy with the activation of pre-existing stimulators specific for the kidney.

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Accelerated Transport of a-Aminoisobutyric Acid in Kidney During Compensatory Hypertrophy

Cited by 5 publications

References 5 publications

Cyclic AMP Mediated Increased Amino Acid Transport: Effect of Isoproterenol Administration

Cyclic AMP Mediated Increased Amino Acid Transport: Effect of Isoproterenol Administration

Renal Growth Factor

Humoral factors in regulation of compensatory renal hypertrophy

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