Accelerated spectroscopic imaging of hyperpolarized C‐13 pyruvate using SENSE parallel imaging

Arunachalam, Arjun; Whitt, David; Fish, Kenneth; Giaquinto, Randy O.; Piel, Joseph E.; Watkins, Ronald D.; Hancu, Ileana

doi:10.1002/nbm.1401

Cited by 46 publications

(171 citation statements)

References 18 publications

Supporting

Mentioning

171

Contrasting

Order By: Relevance

“…SENSE has been used to reduce 2D acquisition from 43 seconds to 14 seconds [162], and parallel imaging with EPSI has been used to collect 3D pyruvate and lactate images from rat kidneys in a few seconds [163]. …”

Section: Magnetic Resonance Spectroscopic Imagingmentioning

confidence: 99%

Recent advances in parallel imaging for MRI

Hamilton

Franson

Seiberlich

2017

Progress in Nuclear Magnetic Resonance Spectroscopy

177

125

View full text Add to dashboard Cite

Magnetic Resonance Imaging (MRI) is an essential technology in modern medicine. However, one of its main drawbacks is the long scan time needed to localize the MR signal in space to generate an image. This review article summarizes some basic principles and recent developments in parallel imaging, a class of image reconstruction techniques for shortening scan time. First, the fundamentals of MRI data acquisition are covered, including the concepts of k-space, undersampling, and aliasing. It is demonstrated that scan time can be reduced by sampling a smaller number of phase encoding lines in k-space; however, without further processing, the resulting images will be degraded by aliasing artifacts. Nearly all modern clinical scanners acquire data from multiple independent receiver coil arrays. Parallel imaging methods exploit properties of these coil arrays to separate aliased pixels in the image domain or to estimate missing k-space data using knowledge of nearby acquired k-space points. Three parallel imaging methods—SENSE, GRAPPA, and SPIRiT—are described in detail, since they are employed clinically and form the foundation for more advanced methods. These techniques can be extended to non-Cartesian sampling patterns, where the collected k-space points do not fall on a rectangular grid. Non-Cartesian acquisitions have several beneficial properties, the most important being the appearance of incoherent aliasing artifacts. Recent advances in simultaneous multi-slice imaging are presented next, which use parallel imaging to disentangle images of several slices that have been acquired at once. Parallel imaging can also be employed to accelerate 3D MRI, in which a contiguous volume is scanned rather than sequential slices. Another class of phase-constrained parallel imaging methods takes advantage of both image magnitude and phase to achieve better reconstruction performance. Finally, some applications are presented of parallel imaging being used to accelerate MR Spectroscopic Imaging.

show abstract

Section: Magnetic Resonance Spectroscopic Imagingmentioning

confidence: 99%

Recent advances in parallel imaging for MRI

Hamilton

Franson

Seiberlich

2017

Progress in Nuclear Magnetic Resonance Spectroscopy

177

125

View full text Add to dashboard Cite

show abstract

“…Parallel imaging has been shown to yield significant reductions in acquisition speed and generally does not carry the signal-to-noise penalty that is observed in traditional 1 H MRI [132,156,157]. Another approach is to implement compressed sensing into the imaging sequence to exploit the sparsity of the NMR spectrum.…”

Section: Hyperpolarized Mri Acquisition Techniquesmentioning

confidence: 99%

The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging

Siddiqui

Kadlecek

Pourfathi

et al. 2017

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Until recently, molecular imaging using magnetic resonance (MR) has been limited by the modality’s low sensitivity, especially with non-proton nuclei. The advent of hyperpolarized (HP) MR overcomes this limitation by substantially enhancing the signal of certain biologically important probes through a process known as external nuclear polarization, enabling real-time assessment of tissue function and metabolism. The metabolic information obtained by HP MR imaging holds significant promise in the clinic, where it could play a critical role in disease diagnosis and therapeutic monitoring. This review will provide a comprehensive overview of the developments made in the field of hyperpolarized MR, including advancements in polarization techniques and delivery, probe development, pulse sequence optimization, characterization of healthy and diseased tissues, and the steps made towards clinical translation.

show abstract

“…Furthermore, if the unaccelerated acquisition times are long relative to T 1 or metabolic conversion (Figure 11), then accelerated acquisitions can reduce the losses due to these factors during the acquisition and so increase the SNR. 52 Compressed Sensing. HP MRS is particularly well suited for compressed sensing 53 because experimental methods can be designed to fulfill the key requirements of: (i) having sufficient SNR for acceleration (provided by the hyperpolarization and VFA strategies); (ii) having signal sparsity in some domain (typically in the spectral dimension, but also in spatial dimensions); (iii) being amenable to pseudorandom k-space sampling strategies that create incoherent aliasing in the sparsity domain; and (iv), incorporating nonlinear reconstruction methods.…”

Section: Acceleration Strategiesmentioning

confidence: 99%

“…It requires an RF receiver coil array, and exploits the spatial localization information provided by these different coils in order to accelerate the acquisition by a factor of R. Interestingly, the SNR in HP parallel imaging performed with VFAs does not suffer from the usual acceleration penalty of √ R in thermal equilibrium acquisitions. 52 However, there is still SNR loss due to the g-factor (geometric factor) when using parallel imaging with HP agents that depend on the coil geometry, object geometry, sampling pattern, and reconstruction method:…”

Section: Acceleration Strategiesmentioning

confidence: 99%

Pulse Sequences for Hyperpolarized MRS

Gordon

Larson

2016

eMagRes

View full text Add to dashboard Cite

Hyperpolarization offers substantial gains in sensitivity for magnetic resonance (MR) spectroscopy (MRS) and imaging (MRI), which are particularly beneficial for providing novel functional information not accessible to conventional MRS and MRI. However, hyperpolarized MR requires tailored pulse sequences because of its unique magnetization behavior, including its decay back to thermal equilibrium, spin exchange, and metabolic conversion of the hyperpolarized magnetization. In addition, rapid delivery of the hyperpolarized media from the polarizer to the subject is key to success. This article begins by describing the unique behavior of hyperpolarized agents and the problems associated with their delivery, focusing on 13 C-labeled pyruvate. Efficient RF and acquisition strategies that include variable flip angles, spectral-spatial RF pulses that address problems with chemical shift displacement artifacts, hyperpolarized slice profile distortions, and the effects of magnetic field inhomogeneity are presented. Acquisition strategies covered include MR spectroscopic imaging with phase encoding and time-dependent readout gradient trajectories, model-based methods, metabolite-specific imaging, steady-state free-precession, and ultrafast two-dimensional NMR. The integration of compressed sensing and parallel imaging into hyperpolarized MR for acceleration is also examined.

show abstract

Accelerated spectroscopic imaging of hyperpolarized C‐13 pyruvate using SENSE parallel imaging

Cited by 46 publications

References 18 publications

Recent advances in parallel imaging for MRI

Recent advances in parallel imaging for MRI

The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging

Pulse Sequences for Hyperpolarized MRS

Contact Info

Product

Resources

About