Accelerated Partial-Breast Irradiation (APBI) Using Protons for Patients with Early-Stage Breast Cancer: A Comparison with 3D Conformal Photon/Electron Based Treatment

Taghian, Alphonse G.; Kozak, Kevin R.; Adams, Judith; Doppke, Karen P.; Nyamwanda, Jacqueline A.; Crowley, Elizabeth; Smith, Barbara L.; Gadd, Michele A.; Habin, Karleen; Katz, Angela; Powell, Simon N.; Lu, Hsiao‐Ming

doi:10.1016/j.ijrobp.2005.07.021

Cited by 5 publications

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“…Taghian et al . have published the dosimetric comparison of APBI using protons with 3D conformal photon/electron based radiotherapy in 17 patients with early breast cancer [ 51 ]. PTV coverage for both modalities was equivalent.…”

Section: Methodsmentioning

confidence: 99%

Radiation therapy planning with photons and protons for early and advanced breast cancer: an overview

et al. 2006

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Postoperative radiation therapy substantially decreases local relapse and moderately reduces breast cancer mortality, but can be associated with increased late mortality due to cardiovascular morbidity and secondary malignancies. Sophistication of breast irradiation techniques, including conformal radiotherapy and intensity modulated radiation therapy, has been shown to markedly reduce cardiac and lung irradiation. The delivery of more conformal treatment can also be achieved with particle beam therapy using protons. Protons have superior dose distributional qualities compared to photons, as dose deposition occurs in a modulated narrow zone, called the Bragg peak. As a result, further dose optimization in breast cancer treatment can be reasonably expected with protons. In this review, we outline the potential indications and benefits of breast cancer radiotherapy with protons. Comparative planning studies and preliminary clinical data are detailed and future developments are considered.

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Section: Methodsmentioning

confidence: 99%

Radiation therapy planning with photons and protons for early and advanced breast cancer: an overview

et al. 2006

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“…But a significant proportion of women are either not offered BCS or do not have radiotherapy after conservative surgery because of the cost of surgery and nursing care during the 5-7 weeks of daily radiotherapy [6,7]. In addition, the necessity of providing WBI for all patients after BCS has been questioned, and several centers have evaluated the feasibility and efficacy of accelerated partial breast irradiation (APBI) [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…External beam APBI has a wide availability and is costeffective as compared to WBI [11][12][13][14][15], and therefore it is the most widely used APBI technology at present. Although it may be assumed that APBI would be an improvement over WBI in certain situations, it cannot be presumed that APBI would have less effect on QoL due to similar local toxicities.…”

Section: Introductionmentioning

confidence: 99%

A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China

Tong

et al. 2011

Breast Cancer Res Treat

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To compare quality of life (QoL) of early breast cancer patients treated with either accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) after breast-conserving therapy in China. The functional assessment of chronic illness therapy-Breast, traditional Chinese version 4 (FACT-B) instruments were given to 84 women (31 APBI and 53 WBI) who attended the radiotherapy clinic between July 2006 and May 2009 at Cancer Center of Sun Yat-sen University. Baseline characteristics and Karnofsky performance status scores were not different between the two groups. The median follow-up period in the APBI group was 29 versus 34 months in the WBI group. The APBI group scores in the physical domain, functional domain, social domain, and breast-specific concerns of FACT-B were 23.01 ± 3.91, 17.97 ± 4.99, 20.87 ± 4.80, and 22.55 ± 5.45, respectively, and were not significantly different from those of the WBI group (22.80 ± 3.50, 17.50 ± 4.40, 20.13 ± 5.31, 23.81 ± 4.65, respectively, P = 0.987, P = 0.476, P = 0.442, P = 0.330, respectively). However, the scores of the APBI group with respect to the emotional domains were lower compared to those of the WBI group (16.84 ± 3.86 vs. 19.47 ± 3.45, respectively, P = 0.002). Compared with women who underwent WBI, women treated with APBI were shown to have no significantly better QoL outcome, and yet had worse emotional response to their treatment.

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“…Quand une seule sé ance par jour est utilisé e, la dose est de 30 Gy en cinq fractions de 6 Gy un jour sur deux [9,10,12,23]. Avec cette technique, la dose é valué e au niveau du poumon homolaté ral é tait de 16,7 % de la dose prescrite au lit opé ratoire.…”

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Accelerated partial breast irradiation: a true therapeutic option for breast cancer patients who have good prognoses

et al. 2008

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Ré sumé : Aprè s une chirurgie conservatrice, la radiothé rapie adjuvante de la totalité de la glande mammaire reste le standard thé rapeutique. L'irradiation partielle accé lé ré e du sein (IPAS) et focalisé e au lit opé ratoire, dé livré e en quelques jours, constitue, dans le contexte de l'individualisation des traitements, une vraie option thé rapeutique et un domaine de recherche prometteur qui permettrait une é volution historique de la radiothé rapie mammaire. La duré e plus courte du traitement (et la possibilité d'instituer rapidement les traitements mé dicaux), une meilleure observance thé rapeutique et l'absence de recours à la mastectomie totale ont é té considé ré es comme des arguments importants pour lé gitimer l'option de l'IPAS outre-Atlantique. Mê me si le profil de patientes idé al pour une IPAS n'est pas encore clairement dé fini, la tentation d'é largir les indications est grande chez les dé fenseurs du concept. Ce profil sera certainement basé sur un faisceau d'arguments qui seront discuté s dans cet article. Motsclé s : Radiothé rapie -Cancers du sein -Irradiation partielle du seinAccelerated partial breast irradiation: a true therapeutic option for breast cancer patients who have good prognoses Abstract: After conservative surgery, whole-breast radiation therapy remains the standard of care. Accelerated partial breast irradiation (APBI) delivered for one week is a new research avenue in individualized treatment and may lead to historic change in adjuvant breast radiation therapy. In North America, several factors, such as the duration of irradiation allowing early medical treatment, better treatment compliance and the decrease in total mastectomies, allowed the development of APBI. Although the ideal candidate for APBI has not been determined, several teams are advocating increased use of the procedure in a higher proportion of patients. Defining the appropriate selection criteria is crucial for future trials. In this paper, we discuss these selection criteria for better treatment individualization.

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Accelerated Partial-Breast Irradiation (APBI) Using Protons for Patients with Early-Stage Breast Cancer: A Comparison with 3D Conformal Photon/Electron Based Treatment

Cited by 5 publications

References 0 publications

Radiation therapy planning with photons and protons for early and advanced breast cancer: an overview

Radiation therapy planning with photons and protons for early and advanced breast cancer: an overview

A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China

Accelerated partial breast irradiation: a true therapeutic option for breast cancer patients who have good prognoses

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