Accelerated onset of diabetes in non‐obese diabetic mice fed a refined high‐fat diet
Heidi M. Batdorf,
Luz de Luna Lawes,
Gabrielle A. Cassagne
et al.
Abstract:AimType 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non‐obese diabetic (NOD) mice.MethodsFemale NOD mice were fed either unrefined diets or matched refined low‐ and high‐fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbi… Show more
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