Accelerated Muscle Recovery After In Vivo Curcumin Supplementation

Tsai, Sen Wei; Huang, Chih‐Wei; Hsu, Yi Ju; Chen, Chun‐Jung; Lee, Po Ying; Huang, Yao Zhi; Lee, Mon Chien; Chiu, Yen Shuo; Tung, Yu Tang

doi:10.1177/1934578x20901898

Cited by 5 publications

(3 citation statements)

References 57 publications

(67 reference statements)

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“…Further, curcumin might enter the circulatory system via diffusion for transportation throughout the body. In previous studies, curcumin was found to play important roles in wound healing acceleration, endothelial cell proliferation, inducible nitric oxide stimulation, and anti-inflammatory and antioxidant activities [ 33 , 34 ]. Cur-SHAP may thus exert antioxidant effects and promote tissue repair in the recovery from LPS-induced muscle injury.…”

Section: Discussionmentioning

confidence: 99%

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

et al. 2021

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Oxidative stress and later-induced chronic inflammation have been reported to play an important role on the progression of sarcopenia. Current treatments for sarcopenia are mainly administered to patients whom sarcopenia already developed. However, there has been no promising results shown in therapy. Therefore, the development of therapeutic and preventive strategies against sarcopenia would be necessary. Curcumin is a traditional medicine that possesses anti-inflammatory and antioxidative properties. In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP). It was, subsequently, utilized for delivery to the patient’s body via intramuscular injection in order to achieve constant release for more than 2 weeks, preventing the progression of the sarcopenia or even leading to recovery from the early stage of the illness. According to the results of WST-1, LIVE/DEAD, DCFDA, and gene expression assays, Cur-SHAP exhibited good biocompatibility and showed great antioxidant/anti-inflammatory effects through the endocytic pathway. The results of the animal studies showed that the muscle endurance, grip strength, and fat/lean mass ratio were all improved in Cur-SHAP-treated rats from LPS-induced sarcopenia. In summary, we successfully synthesized hydrophobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route. The LPS-induced sarcopenia rats were able to recover from disease after the Cur-SHAP treatment.

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Section: Discussionmentioning

confidence: 99%

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

et al. 2021

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“…Curcumin also shows anti-inflammatory effects by downregulating NF-κB expression and suppressing COX-2 production, both of which have a vital role in the inflammatory cascade. 20 In this study, administration of oral curcumin to resistance exercise did not show a significant Front Physiol 2016; 7(8): 1-10.…”

Section: Discussionmentioning

confidence: 52%

Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus

Pawana¹,

Kusumawardani²,

Arfianti³

2022

IndoJPMR

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Introduction: The aim of this study was to explore the effect of adding oral curcumin to resistance exerciseafter immobilization on the diameter of skeletal muscle fiber in Rattus Norvegicus.Methods: This was a post-test only study design on animal model. Subjects of the study were male Rattusnorvegicus strain Wistar, age 10-12 weeks old, weigh between 150-300 g, were immobilized at soleusmuscle for 2 weeks, then randomly allocated to 3 groups: (i) control group, (ii) resistance exercise, (iii)oral curcumin + resistance exercise. After 4 weeks of intervention, the diameter of the muscle fibers wasmeasured.Result: The results of this study showed a significant difference on the diameter of skeletal muscle fiberbetween control group and resistance exercise, as well as control group and resistance exercise + oralcurcumin (p<0.05). There was no significant difference between resistance exercise only and resistanceexercise + oral curcumin (p>0.05).Conclusion: Administration of oral curcumin to resistance exercise after immobilization does not affectskeletal muscle fiber diameter in Rattus Norvegicus.Keywords : curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.

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“…In vitro studies showed that curcumin suppresses the production of TNF-α and IL-1 by human macrophages [ 18 ]. In addition, curcumin ingestion reduces muscle damage following exercise [ 19 ], improves muscle performance, reduces muscle inflammation after hind limb ischemia [ 20 ] and following muscle injury [ 21 – 23 ]. Moreover, curcumin attenuates inflammation following exercise-induced muscle damage and ischemia-reperfusion injury [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of chitosan and curcumin nanoparticles against skeletal muscle fibrosis at early regenerative stage of glycerol-injured rat muscles

Mahdy

Akl

Madkour

2022

BMC Musculoskelet Disord

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Introduction Chitosan and curcumin are natural products that have a wide range of beneficial effects including wound healing. However, their high molecular weight and poor water solubility limit their applications. Aims Therefore, the current study aims to evaluate the effects of chitosan (Cs) and curcumin (Cn) nanoparticles (NPs) on fibrosis and regeneration of glycerol-injured muscle. Methods Muscle injury was induced by intramuscular injection of glycerol into the tibialis anterior muscle of rats. Cs-NPs and Cn-NPs were administered at different doses intraperitoneally after injury. Injured muscles were collected at day 7 after injury, and muscle fibrosis and regeneration were assessed. Results The present results revealed that Cs-NPs and Cn-NPs treatment significantly decreased fibrosis index and increased the average myotube diameter with shifting of the distribution of myotube diameters towards larger diameters in a dose-dependent manner. Immunohistochemical analysis revealed that Cs-NPs and Cn-NPs treatment significantly decreased the number of CD-68+ cells and Col-1+ area. Results showed that Cn-NPs had a higher protective effect, in the form of attenuating muscle fibrosis and inflammation, and enhancing muscle regeneration, than that of Cs-NPs. Conclusions To our knowledge, this is the first study to document the effects of Cs-NPs in injured muscles. The results of study might be a novel approach to attenuate muscle fibrosis in humans using curcumin and chitosan nanoparticles.

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Accelerated Muscle Recovery After In Vivo Curcumin Supplementation

Cited by 5 publications

References 57 publications

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention

Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus

Effect of chitosan and curcumin nanoparticles against skeletal muscle fibrosis at early regenerative stage of glycerol-injured rat muscles

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