Accelerated long-term forgetting in children with temporal lobe epilepsy

Rethinking cognition and behavior in the new classification for childhood epilepsy: Examples from frontal lobe and temporal lobe epilepsies

“…One described a teenager with bilateral frontal foci who experienced a transitory "frontal lobe syndrome" during the [21] 21 n/r b n/a Cohen [23] n/a 24 11.21 6-16.3 Jambaque et al [24] n/a 28 n/r 7-14 Gonzalez et al [25] n/a 43 12.06 5-16 Nolan et al [26] 25 12.8 n/r 32 12.5 n/r Smith & Lah [27] n/a 66 13.55 5.17-18.17 Rzezak et al [28] n/a 19 14.46 8-16 Hershey et al [29] n/a 28 11.20 7-16 Gascoigne et al [30] n/a 23 12.5 n/r Oitment et al [31] n/a 41 n/r 6-18 Gonzalez et al [32] n/a 44 12.23 6-16 Gascoigne et al [33] n/a 21 12 [40] n/a 36 n/r 7-16 a n/a: no patients within this group included in study. b n/r: data not reported in paper.…”

“…These children are adversely affected by interference over relatively short delay intervals [29]. Even when the materials are learned through extensive repetition to a criterion that is matched to that of healthy controls, children with TLE show abnormally rapid forgetting, in that their recall after one week is impoverished [30]. TLE has also been associated with deficits in aspects of semantic memory, as evident on measures of mental scanning for semantic clues, object naming, verbal fluency, and word definitions [27,28].…”

“…Performance on memory tests may change over time, particularly in children with right temporal lobe seizures [41]. Deficits in rapid forgetting and in autobiographical memory associated with temporal lobe epilepsy were more apparent with increasing age across childhood [30,33], whereas preadolescent children with FLE were found to have more difficulties than older children on tests of executive function and motor coordination [35]. The developmental stage of the cognitive function in question at the time of seizure onset can also influence the nature of cognitive impairment, with skills in a critical phase of development being more vulnerable to disruption than those in a stable developmental phase [42].…”

Remembrance and time passed: Memory outcomes 4–11 years after pediatric epilepsy surgery

“…[1][2][3][4] Among children with intractable epilepsy, we have found previously that patients score on average 1.2 standard deviations (SDs) below normative data on memory tasks of episodic and semantic verbal memory and on visual measures such as face recognition. [1][2][3][4] Among children with intractable epilepsy, we have found previously that patients score on average 1.2 standard deviations (SDs) below normative data on memory tasks of episodic and semantic verbal memory and on visual measures such as face recognition.…”

Third International Congress on Epilepsy, Brain, and Mind: Part 2

“…Indeed, current evidence suggests that ALF may be more prevalent in those with some forms of epilepsy, such as TLE, than others, such as idiopathic generalized epilepsy [97]. In addition, ALF has not been shown to be present in all people with TLE [97,98]. Given the inconsistent findings in this area, there is a need for further well-designed studies to probe the distinction between standard and nonstandard forms of forgetting in patients with epilepsy, which may provide insight into their separate or shared mechanisms.…”