Accelerated Identification of Halogenated Monoterpenes from Australian Specimens of the Red Algae <i>Plocamium hamatum</i> and <i>Plocamium costatum</i>

Motti, Cherie A.; Thomas-Hall, Peter; Hagiwara, Kehau A.; Simmons, Charles J.; Willis, Rick; Wright, Anthony D.

doi:10.1021/np500059h

Cited by 16 publications

(16 citation statements)

References 28 publications

(82 reference statements)

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“…There was the usual range of structural types with glycolipids 698 478 and 699-701, 479 halogenated allenes and alkynes 702-704, 480 489 and the mahorones 738-739, unusual 2,3-dibrominated 2-cyclopentenones. 490 The use of rapid dereplication tools (UHPLC-PDA-HRMS, 2D HSQC NMR, soware tools and databases) for identication of the allenes 710 and 711 482 and LC-UV-MS-SPE-NMR for the monoterpenes 712-718 483 were notable features.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2016

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This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1378 in 456 papers for 2014), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2016

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“…[1] Eight new halogenated monoterpenes 11-18 (Scheme 4) were found in the red alga Plocamium hamatum from Moreton Bay, Queensland, and Plocamium costatum from Pandalowie Bay, South Australia. [5] These compounds were inactive against Candida albicans, Mycobacterium smegmatis, Staphylococcus aureus and Escherichia coli.…”

Section: Algaementioning

confidence: 99%

A recent survey of naturally occurring organohalogen compounds

2015

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Environmental context. The general perception that nature does not produce compounds containing halogens -chlorine, bromine, iodine and fluorine -is now known to be erroneous. Modern isolation and identification techniques have led to the discovery of more than 5000 halogen-containing compounds from myriad marine and terrestrial plant and animal sources. Many of these compounds possess extraordinary biological activity, including anticancer, antiviral and antibacterial activity of potential human benefit.Abstract. This short review presents the naturally occurring organohalogen compounds discovered and characterised in 2014. They include compounds from both marine and terrestrial organisms, such as algae, sponges, corals, tunicates, bryozoans, fungi, bacteria, cyanobacteria and plants. Several novel structural types have been characterised. From only ,24 in 1968, naturally occurring organohalogens currently number more than 5000, and they continue to be discovered in all regions of the world. This review presents the 114 discovered organohalogens from natural sources in the year 2014.The enormous upsurge in the total number of natural organohalogens discovered since 1968 arises from several factors: (1) a worldwide revitalisation of natural products research in the search for new medicinal compounds from all aspects of our environment, (2) improved isolation, separation and identification techniques, (3) selective bioassays to identify biologically active extracts, (4) an awareness of folk medicine and ethnobotany for guidance to potentially important organisms.

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“…In 2014 P. costatum was revisited and studied using HPLC-UV-MS-SPE-NMR analysis yielding, among others, the natural products 357, 358, 361-364. All compounds from this study underwent anti-microbial screening against C. albicans, M. smegmatis, S. aureus and E. coli, but were all found to be inactive [125]. The compound aplysiaterpenoid A (365) was isolated from the red alga P. leptophyllum in a bioassay guided fractionation using antifeedant activity as the guiding factor in isolation.…”

Section: Halogenated Monoterpenesmentioning

confidence: 99%

Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

et al. 2020

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Marine macroalgae occurring in the south eastern region of Victoria, Australia, consisting of Port Phillip Bay and the heads entering the bay, is the focus of this review. This area is home to approximately 200 different species of macroalgae, representing the three major phyla of the green algae (Chlorophyta), brown algae (Ochrophyta) and the red algae (Rhodophyta), respectively. Over almost 50 years, the species of macroalgae associated and occurring within this area have resulted in the identification of a number of different types of secondary metabolites including terpenoids, sterols/steroids, phenolic acids, phenols, lipids/polyenes, pheromones, xanthophylls and phloroglucinols. Many of these compounds have subsequently displayed a variety of bioactivities. A systematic description of the compound classes and their associated bioactivities from marine macroalgae found within this region is presented.

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Accelerated Identification of Halogenated Monoterpenes from Australian Specimens of the Red Algae Plocamium hamatum and Plocamium costatum

Cited by 16 publications

References 28 publications

Marine natural products

Marine natural products

A recent survey of naturally occurring organohalogen compounds

Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

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