Accelerated Hypofractionated Chemoradiation Followed by Stereotactic Ablative Radiotherapy Boost for Locally Advanced, Unresectable Non–Small Cell Lung Cancer
Trudy C. Wu,
Elaine Luterstein,
Beth K. Neilsen
et al.
Abstract:ImportanceIntrathoracic progression remains the predominant pattern of failure in patients treated with concurrent chemoradiation followed by a consolidation immune checkpoint inhibitor for locally advanced, unresectable non–small cell lung cancer (NSCLC).ObjectiveTo determine the maximum tolerated dose (MTD) and use of hypofractionated concurrent chemoradiation with an adaptive stereotactic ablative radiotherapy (SABR) boost.Design, Setting, and ParticipantsThis was an early-phase, single-institution, radiati… Show more
“…Most of these clinical studies focus on a specific disease stage and the number of clinical studies for patients with a metastasized form of cancer is rising. [1][2][3][4][5] There are many forms of metastasized disease and the aggressiveness of treatment while having stage IV disease substantially differs across cancers. Moreover, systemic treatment while having stage IV disease in some instances may be regarded as part of treating a chronic disease (such as in breast-or prostate cancer) and in some instances as a form of palliative treatment in which additional life prolongation may for instance be 6 months (such as in lung cancer).…”
“…Most of these clinical studies focus on a specific disease stage and the number of clinical studies for patients with a metastasized form of cancer is rising. [1][2][3][4][5] There are many forms of metastasized disease and the aggressiveness of treatment while having stage IV disease substantially differs across cancers. Moreover, systemic treatment while having stage IV disease in some instances may be regarded as part of treating a chronic disease (such as in breast-or prostate cancer) and in some instances as a form of palliative treatment in which additional life prolongation may for instance be 6 months (such as in lung cancer).…”
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