Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model

Farahpour, Mohammad Reza; Pirkhezr, Ehsan; Ashrafian, Ali; Sonboli, Ali

doi:10.1016/j.biopha.2020.110120

Cited by 69 publications

(53 citation statements)

References 29 publications

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“…The bacteria are commonly detected in the upper and deepest region of wound bed (Serra et al 2015). Colonization of S. aureus and P. aeruginosa in the wound site postpones the wound healing process (Farahpour et al 2020;Khezri et al 2020). The wound healing process comprises several phases, including coagulation, inflammation, epithelialization, granulation tissue formation, and tissue remodelling (Daemi et al 2019a(Daemi et al , 2019bFarahpour et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Colonization of S. aureus and P. aeruginosa in the wound site postpones the wound healing process (Farahpour et al 2020;Khezri et al 2020). The wound healing process comprises several phases, including coagulation, inflammation, epithelialization, granulation tissue formation, and tissue remodelling (Daemi et al 2019a(Daemi et al , 2019bFarahpour et al 2020). Inflammatory phase occurs after activation of inflammatory chemokines (Farahpour et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…The wound healing process comprises several phases, including coagulation, inflammation, epithelialization, granulation tissue formation, and tissue remodelling (Daemi et al 2019a(Daemi et al , 2019bFarahpour et al 2020). Inflammatory phase occurs after activation of inflammatory chemokines (Farahpour et al 2020). Interleukin-1b (IL-1b) is significantly synthesized 12-24 h after infliction of the wound, and its level returns to basal level after the proliferative stage is completed (Fahey and Doyle 2019).…”

Section: Introductionmentioning

confidence: 99%

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Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis

Farahpour

Sheikh

Kafshdooz

et al. 2020

Pharmaceutical Biology

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Context: Zataria multiflora Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection. Objective: This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds. Materials and methods: A full-thickness excisional skin wound was surgically created in each mouse and inoculated with 5 Â 10 7 suspension containing Pseudomonas aeruginosa and Staphylococcus aureus. The BALB/c mice (n ¼ 72) were divided into four groups: (1) negative control that received base ointment (NCG), (2) positive control that daily received Mupirocin V R (MG), (3) therapeutic ointment containing 2% ZMEO and (4) therapeutic ointment containing 4% ZMEO, for 21 days. Wound contraction, total bacterial count, histopathological parameters, antioxidant activity, qRT-PCR analysis for expression of IL-1b, TNF-a, VEGF, IGF-1, TGF-b, IL-10, and FGF-2 mRNA levels were assessed on days 3, 7, and 14 following the wounding. Results: Topical administration of ZMEO significantly decreased the total bacterial count and wound area and also expression of IL-1b and TNF-a compared to the control groups (p < 0.05) in all days. This could also increase significantly the expression of TGF-b, IL-10 IGF-1, FGF-2, and VEGF, and also angiogenesis, fibroblasts, fibrocytes, epithelialization ratio, and collagen deposition and improve antioxidant status compared to the control group (p < 0.05). Discussion and conclusion: ZMEO accelerated the healing process of infected wounds by shortening the inflammatory factors and increasing proliferative phase. Applying ZMEO only and/or in combination with chemical agents for the treatment of wound healing could be suggested.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis

Farahpour

Sheikh

Kafshdooz

et al. 2020

Pharmaceutical Biology

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“…The used in vitro and in vivo models are also listed. Salvia officinalis -Infected wound model (BALB/c) [190] Tridax procumbens -B16-F10 (C57BL/6) [86] Curcumol HUVEC [199] Eugenol EAhy.926 [188] Perillyl Alcohol BLMVEC, HUVEC, B16-F10 [198] Zerumbone HUVEC, CAM, rat aortic ring assay [195,196] β-Caryophyllene B16-F10 (C57BL/6N) [140] β-Elemene CAM, rat aortic ring assay, B16-F10 (C57BL/6) [120,152] Human Umbilical Vein Endothelial Cells (HUVEC), transformed human umbilical vein endothelial cells produced by fusion of A549/8 lung adenocarcinoma with human umbilical endothelial cells (EAhy.926), Bovine Lung Microvascular Endothelial Cells (BLMVEC), chick embryo chorioallantoic membrane (CAM). Where not reported, EO active components were not available in the cited paper.…”

Section: Inhibition Of Angiogenesis and Lymphangiogenesismentioning

confidence: 99%

“…Promotion of the healing process by Salvia officinalis EO was attributed to enhanced angiogenesis through upregulation of VEGF and fibroblast growth factor-2 (FGF-2) expression. An increase in the number of blood vessels and fibroblasts, through cyclin-D1 pathway activation and enhanced expression of Bcl-2, was also observed [ 190 ]. A positive effect on wound healing process has also been described for other EOs such as lavender EO, TTO, Alpinia zerumbet and Chrysantemum boreale Makino EO and their use has been suggested for the treatment of wounds, burns, abscesses or diseases such as diabetes [ 191 , 192 , 193 , 194 ].…”

Section: Mechanism Of Action Of Eos In Melanomamentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Effects of sub‐acute co‐exposure to WIFI (2.45 GHz) and Pistacia lentiscus oil treatment on wound healing by primary intention in male rabbits

Latrach¹,

Chehida²,

Allous³

et al. 2022

Veterinary Medicine & Sci

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Background The bioeffects of WIFI on cutaneous wound healing remains unexplored. In addition, several medicinal plant products including lentisk oil have been shown to interfere with wound healing process. Since the use of this oil is increasing, the co‐exposure (WIFI‐Lentisk oil) assessment is of paramount importance. Objectives We aimed in the present study to investigate the effects of WIFI exposure as well as the application of Pistacia lentiscus oil on sutured wounds (SW). Methods New Zealand male rabbits (n = 24) were used and randomly divided into four groups of six animals each: a control group (SW) and three experimental groups (i) a first group exposed to WIFI (2.45 GHz, 6 h/day) during 16 days (SWW); (ii) a second group exposed to WIFI (2.45 GHz, 6 h/day) during 16 days and treated with lentisk oil (SWWL) and (iii) a third group not exposed to WIFI but treated with lentisk oil (SWL). The wound healing was evaluated by monitoring clinical parameters (temperature, food intake, relative weight variation, and macroscopic aspect) and histology. Results The mean food intake was higher in the SWWL group compared to the three other groups (p < 0.001) and higher in the SWL group compared to the SW group (p = 0.014). The exposition to WIFI (SWW group) or lentisk oil application (SWL group) can promote the collagen deposition and ameliorate the general aspect of wounds. By contrast, the co‐exposure to WIFI and lentisk oil (SWWL) results in antagonist effects and extends the inflammatory phase of wound healing. Conclusions Wounds treated topically with Pistacia lentiscus oil should not be exposed to WIFI.

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Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model

Cited by 69 publications

References 29 publications

Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis

Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Effects of sub‐acute co‐exposure to WIFI (2.45 GHz) and Pistacia lentiscus oil treatment on wound healing by primary intention in male rabbits

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