Accelerated functional losses in ageing congenital Minamata disease patients

Yorifuji, Takashi; Takaoka, Shigeru; Grandjean, Philippe

doi:10.1016/j.ntt.2018.08.001

Cited by 21 publications

(19 citation statements)

References 16 publications

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“…A study of Japanese scientists conducted in the residents of Minamata City exposed to Hg in the 1950s‐1960s reported elevated levels of spontaneous stillbirth and fertility compared with an unexposed population ( P < 0.001). There was an elevated report in the male proportion among stillbirths, which corresponded to a decrease in the proportion of men at birth in the late 1950s . An investigation of the association between fish consumption, Hg content in the hair and sperm parameters among 129 men attending reproductive centres found that an increase in the Hg level in the hair had a direct relationship with the sperm concentration, the total number of spermatozoa and their progressive mobility, taking into account the influence of age, index body‐weight, smoking and alcohol drinking.…”

Section: Organic Mercury and Fertilitymentioning

confidence: 99%

“…There was an elevated report in the male proportion among stillbirths, which corresponded to a decrease in the proportion of men at birth in the late 1950s. 148 An investigation of the association between fish consumption, Hg content in the hair and sperm parameters among 129 men attending reproductive centres found that an increase in the Hg level in the hair had a direct relationship with the sperm concentration, the total number of spermatozoa and their progressive mobility, taking into account the influence of age, index body-weight, smoking and alcohol drinking. This relevance was greater among men who had fish consumption higher than the average in the population.…”

Section: Organic Mercury and Fertilit Ymentioning

confidence: 99%

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Mercury exposure and its effects on fertility and pregnancy outcome

Bjørklund

Chirumbolo

Dadar

et al. 2019

Basic Clin Pharma Tox

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Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminiferous tubules, and testicular degeneration as well as abnormal menstrual cycles. Some studies investigated spontaneous abortion and complicated fertility outcome due to occupational Hg exposure. Moreover, there is a relation between inhaled Hg vapour and reproductive outcome. This MiniReview evaluates the hypothesis that exposure to Hg may increase the risk of reduced fertility, spontaneous abortion and congenital deficits or abnormalities.

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Section: Organic Mercury and Fertilitymentioning

confidence: 99%

Section: Organic Mercury and Fertilit Ymentioning

confidence: 99%

Mercury exposure and its effects on fertility and pregnancy outcome

Bjørklund

Chirumbolo

Dadar

et al. 2019

Basic Clin Pharma Tox

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“…Of note, a pregnant woman who ate seafood heavily contaminated with methylmercury might be unscathed herself but would give birth to a poisoned child with spastic paresis and intellectual disability . Again, the infants’ condition did not improve with time, and patients with congenital mercury poisoning now show increased incapacitation as older adults . A third remarkable event happened in France in the 1960s, where a paediatrician noted the preponderance of alcohol‐dependent women among the mothers of mentally disabled children at an institution .…”

Section: Lifelong Consequences Of Developmental Toxicitymentioning

confidence: 99%

“…5 Again, the infants' condition did not improve with time, and patients with congenital mercury poisoning now show increased incapacitation as older adults. 6 A third remarkable event happened in France in the 1960s, where a paediatrician noted the preponderance of alcohol-dependent women among the mothers of mentally disabled children at an institution. 7 As with lead and mercury, the discovery, later named foetal alcohol syndrome, was at first met with scepticism and disbelief, but adverse effects were subsequently documented at much lower maternal alcohol intake levels, with additional problems, such as behavioural problems and delinquency, emerging at later ages.…”

Section: Lifelong Consequences Of Developmental Toxicitymentioning

confidence: 99%

Timescales of developmental toxicity impacting on research and needs for intervention

Grandjean

Abdennebi-Najar

Barouki

et al. 2018

Basic Clin Pharma Tox

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Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects that can be transgenerationally transferred to future generations. Although epidemiology and toxicology to an increasing degree are exploring the adverse effects from developmental exposures in human beings, the improved documentation has resulted in little progress in protection, and few environmental chemicals are currently regulated to protect against developmental toxicity, whether it be neurotoxicity, endocrine disruption or other adverse outcome. The desire to obtain a high degree of certainty and verification of the evidence used for decision-making must be weighed against the costs and necessary duration of research, as well as the long-term costs to human health because of delayed protection of vulnerable early-life stages of human development and, possibly, future generations. Although two-generation toxicology tests may be useful for initial test purposes, other rapidly emerging tools need to be seriously considered from computational chemistry and metabolomics to CLARITY-BPA-type designs, big data and population record linkage approaches that will allow efficient generation of new insight; epigenetic mechanisms may necessitate a set of additional regulatory tests to reveal such effects. As reflected by the Prenatal Programming and Toxicity (PPTOX) VI conference, the current scientific understanding and the timescales involved require an intensified approach to protect against preventable adverse health effects that can harm the next generation and generations to come. While further research is needed, the main emphasis should be on research translation and timely public health intervention to avoid serious, irreversible and perhaps transgenerational harm.

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“…Although the use of mercury (Hg) by mankind has been going on for centuries, fundamental and applied geochemical, ecological, hygienic and toxicological studies aimed at comprehensively studying and solving the problem of human safety of one of the most toxic chemical elements have been active since the mid-20th century, including in Ukraine [1][2][3][4][5].On the one hand, this was due to the growth of production and use of Hg in various spheres of economy and life, on the other hand, the growing number of acute, chronic poisonings, mercury-dependent pathological changes in the human body [6,7]. Among these is the infamous Minamata disease, which arose after a long diet of one of the regions of Japan contaminated with Hg seafood [8,9]. The multifaceted intersectoral problem of human security in contact with mercury has gained global significance, primarily due to its anthropogenic component.…”

mentioning

confidence: 99%

Toxico-ecological Analysis of Mercury-contained Waste Management in Ukraine

Pykhteyeva

Bolshoy

Shafran

2020

UJMTA

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Relevance. The multifaceted intersectoral problem of human security in contact with mercury has gained global significance in the twentieth century, it is relevant today. Considerable attention is paid to the environmental and hygienic aspects of mercury hazards in the field related to the production and disposal of waste containing Hg. The Aim of the Research. Analyze the data of own research on mercury content in the environment in connection with the management of mercury-containing waste and justify a set of preventive environmental and hygienic, technological and organizational measures to improve safety, public health and improve the environment in the region and the country in general. Materials and Methods. Sampling, sample preparation and determination of mercury content in environmental facilities and bioassays were performed according to MI “Methodical instructions for the determination of mercury in biological material, air, drinking water, food products and the environment.” The concentration of mercury was measured by the method of AAS “cold steam” on the upgraded device “Yulia-2M”. The mercury content in soil and air at the spontaneous dump of mercury lamps in Odessa region, on the border of the sanitary protection zone and in the air of the working zone of the enterprise for utilization of mercury lamps was studied. For sample preparation, chemically pure nitric acid (56%) was used, to reduce mercury during the analysis of chemically pure tin (II) chloride. Results and Conclusions. Mercury lamps have been shown to be hazardous to the environment and human health without proper disposal. Mercury lamps should be collected and disposed of as hazardous waste not only in industrial facilities but also in the general public. The formation of spontaneous unauthorized landfills of mercury lamps is unacceptable. The problem of environmental monitoring needs to be addressed at the state level with the mandatory involvement of specialists in the field of hygiene, toxicology and analytical chemistry of heavy metals in cases of violations to assess the level of danger and make informed decisions on approaches to elimination of mercury sources. Key Words: mercury, mercury lamps, ecology.

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Accelerated functional losses in ageing congenital Minamata disease patients

Cited by 21 publications

References 16 publications

Mercury exposure and its effects on fertility and pregnancy outcome

Mercury exposure and its effects on fertility and pregnancy outcome

Timescales of developmental toxicity impacting on research and needs for intervention

Toxico-ecological Analysis of Mercury-contained Waste Management in Ukraine

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