Accelerated full-thickness wound healing via sustained bFGF delivery based on a PVA/chitosan/gelatin hydrogel incorporating PCL microspheres

Shamloo, Amir; Sarmadi, Morteza; Aghababaie, Zahra; Vossoughi, Manouchehr

doi:10.1016/j.ijpharm.2017.12.045

Cited by 96 publications

(63 citation statements)

References 50 publications

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“…Based on these characteristics, hydrogels are primarily used on pressure ulcers, surgical wounds, burns, radiation dermatitis, etc. (Francesko et al, 2017;Shamloo et al, 2018). They are suitable for wounds with minimal-to-moderate exudate.…”

Section: Wound Dressingsmentioning

confidence: 99%

Selection of Appropriate Wound Dressing for Various Wounds

Shi

Wang

et al. 2020

Front. Bioeng. Biotechnol.

238

140

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There are many factors involved in wound healing, and the healing process is not static. The therapeutic effect of modern wound dressings in the clinical management of wounds is documented. However, there are few reports regarding the reasonable selection of dressings for certain types of wounds in the clinic. In this article, we retrospect the history of wound dressing development and the classification of modern wound dressings. In addition, the pros and cons of mainstream modern wound dressings for the healing of different wounds, such as diabetic foot ulcers, pressure ulcers, burns and scalds, and chronic leg ulcers, as well as the physiological mechanisms involved in wound healing are summarized. This article provides a clinical guideline for selecting suitable wound dressings according to the types of wounds.

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Section: Wound Dressingsmentioning

confidence: 99%

Selection of Appropriate Wound Dressing for Various Wounds

Shi

Wang

et al. 2020

Front. Bioeng. Biotechnol.

238

140

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“…Most of the hydrogels used for wound dressing are usually loaded with drug to increase the rate of healing of the skin. Shamloo et al [214] prepared a PVA/chitosan/gelatin hydrogel embedded with PCL microspheres by a double-emulsion-solvent-evaporation method destined for accelerated wound healing by sustained release of bFGF. Electron beam irradiation (EBI) was used to prepare hybrid keratin based hydrogels in the presence of two synthetic polymers, namely PVA and polyethylenimine (PEI) that influence the gelation rate of keratin [392].…”

Section: Wound Healingmentioning

confidence: 99%

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Vasile¹,

Pamfil²,

Stoleru³

et al. 2020

Molecules

177

110

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New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids, are presented from the point of view of their ability to form hydrogels with synthetic polymers, the preparation procedures for polymeric organic hybrid hydrogels, general physico-chemical properties and main biomedical applications (i.e., tissue engineering, wound dressing, drug delivery, etc.).

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“…However, CS can be dissolved in the stomach due its solubility at low pH condition (pKa 6.5) [177], causing release and denaturation of protein [178]. Therefore, the solubility of CS can be prevented by its association with anionic polymers including alginate [179], pectin [180], gelatin [181], and carrageenan [182] to create hydrogels as oral protein delivery carriers.…”

Section: As Protein Deliveringmentioning

confidence: 99%

“…In order to slow down the degradation rate of hydrogels and prevent burst protein release, polycaprolactone can be incorporated in CS-based hydrogels. Shamloo et al [181] developed poly(vinyl alcohol)/CS/gelatin hydrogel incorporating polycaprolactone microspheres for delivery of basic fibroblast growth factor (bFGF). Poly(vinyl alcohol) and gelatin were used to improve mechanical properties and increase cell adhesion, respectively.…”

Section: As Protein Deliveringmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

Rufato¹,

Galdino²,

Ody³

et al. 2019

Hydrogels - Smart Materials for Biomedical Applications

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Chitosan (CS) is a polymer obtained from chitin, being this, after the cellulose, the most abundant polysaccharide. The fact of (i) CS being obtained from renewable sources; (ii) CS to possess capability for doing interactions with different moieties being such capability dependent of pH; (iii) plenty of possibilities for chemical modification of CS; and (iv) tuning the final properties of CS derivatives makes this polymer very interesting in academic and technological points of view. In this way, hydrogels based on CS and on CS derivatives have been widely used for biomedical applications. Other important technological applications can be also cited, such as adsorbent of metals and dyes in wastewater from industrial effluents. In pharmaceutical field, hydrogels based on CS are often used as drugs' and proteins' carrier formulations due to the inherent characteristics such as the biocompatibility, nontoxicity, hydrophilicity, etc. This chapter is an attempt for updating and joining the plenty of available information regarding the preparation, characterization, and biomedical application of hydrogels based on chitosan and chitosan derivatives. More than 260 references are provided, being the majority of them published in the last 10 years.

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Accelerated full-thickness wound healing via sustained bFGF delivery based on a PVA/chitosan/gelatin hydrogel incorporating PCL microspheres

Cited by 96 publications

References 50 publications

Selection of Appropriate Wound Dressing for Various Wounds

Selection of Appropriate Wound Dressing for Various Wounds

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

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