Accelerated folate breakdown in pregnancy

McPartlin, Joseph; Halligan, Aidan; Scott, John M.; Darling, Michael; Weir, Donald G.

doi:10.1016/0020-7292(93)90258-x

Cited by 27 publications

(35 citation statements)

References 0 publications

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“…Folic acid concentrations are a primary determinant of the metabolism of homocysteine. Several studies suggest that there is an increased metabolic demand for folic acid during pregnancy as a result of the fast-growing conceptus and placenta (15,17,20,21). In addition, it is reasonable to assert that this metabolic demand will be further increased in pregnancies with multiple gestations, and this has lead to the practice of increased supplementation during twin pregnancies (as is the practice at the Magee-Womens Hospital, 1 mg extra in addition to normal prenatal vitamins).…”

Section: Discussionmentioning

confidence: 98%

Maternal Plasma Homocysteine Concentrations Are Not Increased in Twin Pregnancies

Powers¹,

Dunbar²,

Laivuori³

et al. 2005

LHIP

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Section: Discussionmentioning

confidence: 98%

Maternal Plasma Homocysteine Concentrations Are Not Increased in Twin Pregnancies

Powers¹,

Dunbar²,

Laivuori³

et al. 2005

LHIP

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“…For example, it has been suggested that an increase in excretion of folate catabolism during pregnancy would account, in part, for a higher folate requirement (38,52). If folate intake did not meet or exceed excretory and catabolic losses, the mass of tissue folate pools would inevitably decline.…”

Section: Outlook For Determining Folate Requirements Using Kinetic Prmentioning

confidence: 98%

“…This confirms and extends findings of Caudill et al (12) that indicated that there was no difference between second trimester pregnant women and controls in excretion of folate catabolites. However, Irish studies have indicated that urinary excretion of folate catabolites increases during pregnancy (38,52).…”

Section: Relationships Of Folate Kinetics and Healthmentioning

confidence: 98%

IN VIVO KINETICS OF FOLATE METABOLISM

Gregory

Quinlivan²

2002

Annu. Rev. Nutr.

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Investigation of the in vivo kinetics of folate metabolism provides information that contributes to a better understanding of the manner in which this vitamin is processed in vivo. Kinetic studies can yield insight into the requirements for folate, especially with respect to factors that may lead to increased requirements. This review considers the strengths and weaknesses of various approaches to the study of folate kinetics and resulting data, followed by a summary and interpretation of existing data.

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“…This deficiency is associated with increased risk of cardiovascular diseases (Powers, 2003). Folate is important for the prevention of foetal neural tube defects (FAO/WHO, 2001) and folate requirements are significantly higher during pregnancy (McPartlin et al, 1993). Fortification of these vitamins in the food supply has reduced incidences of the respective deficiencies.…”

Section: Riboflavin and Folatementioning

confidence: 99%