Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress

Brodnik, Zachary D.; Black, Emily; España, Rodrigo A.

doi:10.1038/s41386-019-0526-1

Cited by 14 publications

(17 citation statements)

References 76 publications

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“…The elevated plus maze was conducted as described previously [39]. The apparatus comprised two open arms (25 cm × 8 cm × 0.5 cm) and two closed arms (25 cm × 8 cm × 12 cm) that extended from a common central platform (8 cm × 8 cm).…”

Section: Elevated Plus Maze (Epm) Testmentioning

confidence: 99%

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Wang

Yang

Liu

et al. 2020

Aging

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Sleep disorder has become a prevalent issue in current society and is connected with the deterioration of neurobehaviors such as mood, cognition and memory. Ellagic acid (EA) is a phenolic phytoconstituent extracted from grains and fruits that has potent neuroprotective properties. This research aimed to study the alleviative effect and mechanism of EA on memory impairment and anxiety caused by sleep deprivation (SD). EA ameliorated behavioral abnormalities in SD mice, associated with increased dendritic spine density, and reduced shrinkage and loss of hippocampal neurons. EA reduced the inflammatory response and oxidative stress injury caused by SD, which may be related to activation of the Nrf2/HO-1 pathway and mitigation of the TLR4-induced inflammatory response. In addition, EA significantly reduced the mortality and ROS levels in glutamate (Glu)-induced hippocampal neuron injury, and these effects of EA were enhanced in TLR4 siRNA-transfected neurons. However, knockdown of Nrf2 dramatically restrained the protective impact of EA on Glu-induced toxicity. Taken together, EA alleviated memory impairment and anxiety in sleep-deprived mice potentially by inhibiting TLR4 and activating Nrf2. Our findings suggested that EA may be a promising nutraceutical ingredient to prevent cognitive impairment and anxiety caused by sleep loss.

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Section: Elevated Plus Maze (Epm) Testmentioning

confidence: 99%

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Wang

Yang

Liu

et al. 2020

Aging

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“…Additionally, exposure to 2,3,5-trimethyl-3thiazoline (TMT; an extract of fox feces) has been shown to produce alcohol reinstatement (e.g., relapse-like behavior) in mice [18]. Animal models can also be used to examine relevant individual variability in responses to stress [19][20][21][22][23][24], including stress resilience. Previous studies have utilized a variety of methods to classify animals into specific phenotype groups to examine individual variability following the stress exposure.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have utilized a variety of methods to classify animals into specific phenotype groups to examine individual variability following the stress exposure. For example, classification can be based on avoidance behavior during reexposure to a bobcat urine paired context [16,25], behavior during an elevated-plus maze and acoustic startle response following TMT exposure [16,25], and anxiety-like behavior in an elevated plus maze and context avoidance behavior [23,24]. These characterization methods focus on grouping rats based on behavioral changes that occur after exposure to stress.…”

Section: Introductionmentioning

confidence: 99%

Increased alcohol self-administration following exposure to the predator odor TMT in active coping female rats

Ornelas¹,

Tyler²,

Irukulapati³

et al. 2021

Behavioural Brain Research

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Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid. Additionally, individual differences in response to stress suggest resilient and susceptible populations. The current study exposed male and female Long Evans rats to the synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) to examine individual differences in stress-reactive behaviors (digging and immobility) and whether these differences could predict lasting consequences of TMT and increases in alcohol drinking. Male and female Long Evans rats were trained on operant alcohol self-administration. After 9 sessions, rats underwent exposure to TMT or water (Control) in a distinct context. 6 days after TMT exposure, rats underwent re-exposure to the TMT-paired context (without TMT), and a series of behavioral assessments (acoustic startle, zero maze, light/dark box), after which rats resumed alcohol selfadministration. Rats were divided into two TMT-subgroups using a ratio of digging and immobility behavior during TMT exposure: TMT-subgroup 1 (low digging/immobility ratio) and TMT-subgroup 2 (high digging/immobility ratio). Digging/immobility ratio scores predicted elevated corticosterone levels during TMT exposure and reactivity during context re-exposure in males and females (TMT-subgroup 2), as well as elevated corticosterone levels after context re-exposure and hyperarousal behavior in females (TMT-subgroup 1). Furthermore, TMT stress reactivity predicted increases in alcohol self-administration, specifically in females. These data show that stress-reactivity can predict lasting behavioral changes which may lead to a better understanding of increases in alcohol drinking following stress in females and that individual differences .

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“…Sensitivity to reward is modulated by prior experiences, particularly during early developmental periods [1][2][3][4][5][6][7][8][9][10][11]. In the United States, over 30% of children experience some type of early-life adversity (ELA) related to poverty, trauma, and chaotic environments [12] and these events have been associated with poor cognitive and emotional health [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

Kangas

Short

Luc

et al. 2021

Neuropsychopharmacol.

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Exposure to early-life adversity (ELA) is associated with several neuropsychiatric conditions, including major depressive disorder, yet causality is difficult to establish in humans. Recent work in rodents has implicated impaired reward circuit signaling in anhedonic-like behavior after ELA exposure. Anhedonia, the lack of reactivity to previously rewarding stimuli, is a transdiagnostic construct common to mental illnesses associated with ELA. Here, we employed an assay of reward responsiveness validated across species, the Probabilistic Reward Task (PRT). In the PRT, healthy participants reliably develop a response bias toward the more richly rewarded stimulus, whereas participants with anhedonia exhibit a blunted response bias that correlates with current and future anhedonia. In a well-established model of ELA that generates a stressful, chaotic, and unpredictable early-life environment, ELA led to blunted response biases in the PRT in two separate cohorts, recapitulating findings in humans with anhedonia. The same ELA rats had blunted sucrose preference, further supporting their anhedonic-like phenotypes. Probing the aspects of ELA that might provoke these deficits, we quantified the unpredictability of dam/pup interactions using entropy measures and found that the unpredictability of maternal care was significantly higher in the ELA groups in which PRT and sucrose preference reward deficits were present later in life. Taken together, these data position the PRT, established in clinical patient populations, as a potent instrument to assess the impact of ELA on the reward circuit across species. These findings also implicate the unpredictability of maternal signals during early life as an important driver of reward sensitivity deficits.

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Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress

Cited by 14 publications

References 76 publications

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Increased alcohol self-administration following exposure to the predator odor TMT in active coping female rats

A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

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