Accelerated degradation of poly(l-lactide) bone scaffold: Crystallinity and hydrophilicity

Feng, Pei; Jia, Jiye; Yu, Li; Min, Anjie; Yang, Sheng Lin; Shuai, Cijun

doi:10.1016/j.matchemphys.2021.124545

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…As shown in Figure c, chemical incorporation of PAs decreased the initial contact angle. This result is attributed to the addition of hydrophilic ester bonds between glycerol and the PAs and/or the reduced crystallinity after PA incorporation, which increase access of water to polymer chains . Physical incorporation of PAs had larger effects on contact angle than chemical incorporation (Figure d), and the changes over time of storage in PBS are more significant.…”

Section: Resultsmentioning

confidence: 99%

“…This result is attributed to the addition of hydrophilic ester bonds between glycerol and the PAs and/or the reduced crystallinity after PA incorporation, which increase access of water to polymer chains. 57 Physical incorporation of PAs had larger effects on contact angle than chemical incorporation (Figure 2d), and the changes over time of storage in PBS are more significant. In general, increasing concentrations of physically incorporated PAs reduced hydrophobicity, which correlates with reduced crystallinity.…”

Section: Property Changes Over Time Of Incubation In Pbsmentioning

confidence: 99%

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Self-Defensive Antimicrobial Shape Memory Polyurethanes with Honey-Based Compounds

Ramezani,

Labour,

et al. 2023

ACS Appl. Mater. Interfaces

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Infection treatment plays a crucial role in aiding the body in wound healing. To that end, we developed a library of antimicrobial polymers based on segmented shape memory polyurethanes with nondrug-based antimicrobials (i.e., honey-based phenolic acids (PAs)) using both chemical and physical incorporation approaches. The antimicrobial shape memory polymers (SMPs) have high transition temperatures (>55 °C) to enable maintenance of temporary, programmed shapes in physiological conditions unless a specific external stimulus is present. Polymers showed tunable mechanical and shape memory properties by changing the ratio, chemistry, and incorporation method of PAs. Cytocompatible (∼100% cell viability) synthesized polymers inhibited growth rates of Staphylococcus aureus (∼100% with physically incorporated PAs and >80% with chemically incorporated PAs) and Escherichia coli (∼100% for samples with cinnamic acid (physical and chemical)). Crystal violet assays showed that all formulations inhibit biofilm formation in surrounding solutions, and chemically incorporated samples showed surface antibiofilm properties with S. aureus . Molecular dynamics simulations confirm that PAs have higher levels of interactions with S. aureus cell membranes than E. coli . Long-term antimicrobial properties were measured after storage of the sample in aqueous conditions; the polymers retained their antimicrobial properties against E. coli after up to 20 days. As a proof of concept, magnetic particles were incorporated into the polymer to trigger user-defined shape recovery by applying an external magnetic field. Shape recovery disrupted preformed S. aureus biofilms on polymer surfaces. This antimicrobial biomaterial platform could enable user- or environmentally controlled shape change and/or antimicrobial release to enhance infection treatment efforts.

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Section: Resultsmentioning

confidence: 99%

Section: Property Changes Over Time Of Incubation In Pbsmentioning

confidence: 99%

Self-Defensive Antimicrobial Shape Memory Polyurethanes with Honey-Based Compounds

Ramezani,

Labour,

et al. 2023

ACS Appl. Mater. Interfaces

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“…Thus, the degradation of PLLA is accelerated. [221] Acidity and alkalinity of degradation environment are important factors affecting the degradation of synthetic polymers. Both acidic and alkaline environments can accelerate the degradation of polymers.…”

Section: Laminated Object Manufacturingmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

Self Cite

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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“…Feng et al blended l-lactic (L-LA) with PLA, which increased the amorphous region by hindering the crystallization of PLA. This accelerated the hydrolysis of PLA but also decreased the tensile strength and modulus of the composites [ 10 ]. Starch exhibits a similar promoting effect as it not only increases the hydrophilicity of the material but also destroys the crystal structure of PLA.…”

Section: Introductionmentioning

confidence: 99%

The Mechanical Properties and Degradation Behavior of 3D-Printed Cellulose Nanofiber/Polylactic Acid Composites

Zhang,

Cao,

Jiang

2023

Materials

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Polylactic acid (PLA) has been widely used in many fields because of its good biodegradability, biocompatibility, and renewability. This work studied the degradation behavior and mechanical properties of cellulose nanofiber (CNF)/PLA composites. In vitro degradation experiments of 3D-printed samples were conducted at elevated temperatures, and the degradation characteristics were evaluated by mechanical tests, gel permeation chromatography (GPC), differential scanning calorimetric (DSC), and scanning electron microscope (SEM). The results indicated that the addition of CNF (0.5 wt%) accelerated the degradation rate of PLA. The decreases in number average molecular weight (Mn) and weight average molecular weight (Mw) of composites were 7.96% and 4.91% higher than that of neat PLA, respectively. Furthermore, the tensile modulus of composites was 18.4% higher than that of neat PLA, while the strength was 7.4% lower due to poor interfacial bonding between CNF and PLA. A mapping relationship between accelerated and normal degradation showed that the degradation experienced during 60 days at 37 °C was equivalent to that undergone during 14 days at 50 °C; this was achieved by examining the alteration in Mn. Moreover, the degradation process caused a notable deformation in the samples due to residual stress generated during the 3D printing process. This study provided valuable insights for investigating the in vitro degradation behavior of 3D-printed products.

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Accelerated degradation of poly(l-lactide) bone scaffold: Crystallinity and hydrophilicity

Cited by 4 publications

References 41 publications

Self-Defensive Antimicrobial Shape Memory Polyurethanes with Honey-Based Compounds

Self-Defensive Antimicrobial Shape Memory Polyurethanes with Honey-Based Compounds

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

The Mechanical Properties and Degradation Behavior of 3D-Printed Cellulose Nanofiber/Polylactic Acid Composites

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