Accelerated Decrease in Bone Mineral Density in Women Aged 52-57 Years

Abstract

Bone mineral density (BMD) has been known to decline in middle-aged and elderly individuals, but when this decline begins and the rate at which it occurs remain unclear. We thus undertook this study to examine the association between BMD and age by their mean values in women visiting the Shimane Institute of Health Science for medical examination. We performed dual energy X-ray absorptiometry measurement of lumbar vertebrae in 1,167 women, and of the entire skeleton in 1,038 women. The ages of subjects ranged from 30 to 70 years. We found that the mean value of whole-body and lumbar BMD changed little in the age range of 30-51 years, and any change after 58 years was a gradual decrease, unlike the sharp decrease found between 52 and 57 years of age. The effects of endocrine kinetics may be reflected in women by the decrease of bone density relative to age. In conclusion, BMD declines more rapidly in women within the age range of 52-57 years than in those 58 years and over. This regression line is considered useful in predicting BMD of whole-body skeleton and lumbar vertebrae relative to age for the prevention of osteoporosis in women.

Correlation of Body Growth and Bone Mineral Density Measured by Ultrasound Densitometry of the Calcaneus in Children and Adolescents

“…However, RTBA of the calcaneus was higher in girls than in boys. We consider this to be related to the female hormone (Nohara et al 2006); however, we did not investigate the relationship with sex characteristics such as menarche in girls, as we thought that objective data would be difficult to be obtained. One study found that age at onset of puberty, peak height velocity, and menarche was about 9.5, 11, and 12 years, respectively in Japanese girls (Tanaka and Imai 2005).…”

Role of type I collagen C telopeptide, bone‐specific alkaline phosphatase and osteocalcin in the assessment of bone status in postmenopausal women

“…Soon after menopause the osteoporotic risk for women increases. This is due to accelerated bone remodeling as a consequence of estrogen withdrawal 3 . Therefore, it is important to identify postmenopausal women at high risk for future fractures in order to develop effective preventive treatment.…”

“…This is due to accelerated bone remodeling as a consequence of estrogen withdrawal. 3 Therefore, it is important to identify postmenopausal women at high risk for future fractures in order to develop effective preventive treatment. In this context, measurement of bone mineral density (BMD) is of considerable clinical relevance because BMD is one of the best predictors of future osteoporotic bone fractures.…”

Higher Efficacy of Urinary Bone Resorption Marker Measurements in Assessing Response to Treatment for Osteoporosis in Postmenopausal Women

“…BMD is the most frequently used measurement for diagnosing osteoporosis and monitoring osteoporosis treatments in postmenopausal women (Nohara et al 2006). However, changes in BMD following osteoporosis treatment only appear after 6 months or longer.…”