Accelerated Bone Regeneration by Chitosan/Nanometer Hydroxyapatite/Collagen Composite Incorporating BMP-7 Mimetic Peptide

Feng, Bo; Hu, Dongbin; Yang-de, Zhang

doi:10.2485/jhtb.21.481

Cited by 5 publications

(8 citation statements)

References 29 publications

(30 reference statements)

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“…Importantly, this peptide exhibits higher osteogenic potential than BMP-7 [127]. Moreover, another BMP-7 mimetic peptide containing KQLNAISVLYFDD (Lys-Gln-Leu-Asn-Ala-Ile-Ser-Val-eu-Gln-Phe-Asp-Asp) amino acid sequence improves bone regeneration in vivo [128].…”

Section: Bmps-derived Peptidesmentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Bmps-derived Peptidesmentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…Draenert et al [21] had evaluated the biological effect of the growth factor [bone morphogenetic protein (BMP)] on human osteoblasts, which showed that sustained release of BMP on bone biomaterials had a stronger positive effect on biological scaffolds. Chitosan/nano-HA/collagen composite incorporating BMP was fabricated by Feng et al [22], successfully accelerating the healing of rat's cranial bone defects. In conclusion, the further research is much needed to incorporate BMP into FGM for promoting bone regeneration.…”

Section: Methodsmentioning

confidence: 99%

Mechanical performance and in vivo bioactivity of functionally graded PEEK–HA biocomposite materials

Lin

Luo

et al. 2014

J Sol-Gel Sci Technol

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A functionally graded material (FGM) of polyetheretherketone (PEEK)-hydroxyapatite (HA) with a symmetrical three-layer structure containing 8.7, 2.6 and 8.7 vol% HA, respectively, is successfully fabricated by hot pressing and evaluated by scanning electron microscopy and tensile testing. A good bonding between the HA particles and the PEEK matrix is achieved by virtue of an in situ method in fabricating each PEEK-HA composite layer. There are no apparent microcracks and microscopic interfaces within each layer of the FGM. The symmetrical PEEK-HA FGM does not fall apart or delaminate during loading with a tensile strength of 86.2 MPa, and its fracture energy is 56.5 kJ/m 2 . Furthermore, in vivo bioactivity of the FGM sample is also evaluated, showing that it has sound biocompability and bioactivity. Accordingly, the FGM in the future may be a promising biomaterial to be used as replacement implant of human bone through a proper design to balance mechanical properties and bioactivity.

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“…BMP-7-derived peptide (KQLNALSVLYFDD) containing 13 amino acids was built according to the literature (Fig. 1c ) 31 . BMP-7 and its derived peptide molecules were immersed in TIP3P water boxes and charges balanced with sodium and chloride ions.…”

Section: Simulation Methodsmentioning

confidence: 99%

“…However, the structure of BMP-7 is complicated, it degrades easily in the body, and requires considerable time to be produced on a large scale. Thus, BMP-7-derived peptides have attracted attention because of their low-cost and excellent bio-functions 31 . Studies have shown that these peptides from the BMP-7 or BMP-7 receptors can be used to treat bone-related diseases.…”

Section: Introductionmentioning

confidence: 99%

“… 33 prepared a new type of functional, self-assembling peptide nanofiber-hydrogel scaffold with the sequence RADKPS (ARG-ALA-ASP-LYS-PRO-SER); they clearly showed that RADKPS promoted cell proliferation and activity of human degenerative nucleus pulposus cells. Another peptide, KQLNALSVLYFDD (LYS-GLN-LEU-ASN-ALA-LEU-SER-VAL-LEU-TYR-PHE-ASP-ASP), is synthesized from the BMP-7 receptor I- and receptor II-binding active domains 31 and, in addition, has excellent osteogenic activity and induces mineralization of bone marrow stromal stem cells. The structures of BMP-7-derived peptides are simple and easy to integrate into biomaterials while maintaining their biological activities during synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Effects of atomic-level nano-structured hydroxyapatite on adsorption of bone morphogenetic protein-7 and its derived peptide by computer simulation

Wang

et al. 2017

Sci Rep

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Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we evaluated the effects of atomic-level nano-structured HA (110) surfaces on the adsorption of bone morphogenetic protein-7 (BMP-7) and its derived peptide (KQLNALSVLYFDD) using molecular dynamics and density functional theory methods. The results indicated that the atomic-level morphology of HA significantly affected the interaction strength between proteins and HA substrates. The interactions of BMP-7 and its derived peptide with nano-concave and nano-pillar HA surfaces were stronger than those with flat or nano-groove HA surfaces. The results also revealed that if the groove size of nano-structured HA surfaces matched that of residues in the protein or peptide, these residues were likely to spread into the grooves of the nano-groove, nano-concave, and nano-pillar HA, further strengthening the interactions. These results are helpful in better understanding the adsorption behaviors of proteins onto nano-structured HA surfaces, and provide theoretical guidance for designing novel bioceramic materials for bone regeneration and tissue engineering.

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Accelerated Bone Regeneration by Chitosan/Nanometer Hydroxyapatite/Collagen Composite Incorporating BMP-7 Mimetic Peptide

Cited by 5 publications

References 29 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Mechanical performance and in vivo bioactivity of functionally graded PEEK–HA biocomposite materials

Effects of atomic-level nano-structured hydroxyapatite on adsorption of bone morphogenetic protein-7 and its derived peptide by computer simulation

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