Accelerated atherosclerosis in haemodialysis patients; correlation of endothelial function with oxidative DNA damage

Kaya, Yüksel; Arı, Elif; Demır, Halit; Söylemez, Nihat; Çebi, Ayşegül; Alp, Handan; Bakan, Ebubekîr; Geçit, İlhan; Aşıcıoğlu, Ebru; Beytur, Ali

doi:10.1093/ndt/gfr443

Cited by 31 publications

(26 citation statements)

References 28 publications

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“…Increased oxidative stress has been linked to accelerated atherosclerosis and CVD in dialysis patients (34)(35)(36). One study found increased levels of asymmetrical dimethylarginine (37), a compound reflecting oxidative stress, in patients who experienced cardiovascular events or who died (14).…”

Section: Discussionmentioning

confidence: 99%

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Watanabe

Qureshi

et al. 2015

Perit Dial Int

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Section: Discussionmentioning

confidence: 99%

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Watanabe

Qureshi

et al. 2015

Perit Dial Int

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“…Some of these risk factors are angiosteosis, vascular stiffness, accumulation of circulating inflammatory mediators and autonomic dysfunction, which result in CVD becoming the most common cause of morbidity and mortality in patients with CKD receiving dialysis, accounting for 40% [13] . Recent evidence also elucidated an increased incidence and accelerated progress of atherosclerosis in patients with CKD receiving dialysis compared with that of the conventional CVD [14] . H 2 S is an endogenous gas and recognized as a biological mediator with various roles such as neuromodulation, regulation of the vascular tone, cytoprotection, anti-inflammation, oxygen sensing, angiogenesis, and generation of mitochondrial energy.…”

Section: Discussionmentioning

confidence: 99%

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Feng

Wang³

2015

Blood Purif

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Background/Aims: To evaluate the relationship between plasma hydrogen sulfide (H₂S) and cardiovascular risk markers, including pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in chronic hemodialysis (CHD) patients and further investigate the underlying cardiovascular protection mechanism of H₂S. Methods: CHD patients, 113 of them, were studied. Plasma H₂S was measured through zinc acetate reaction. cPKCβII membrane translocation and phosphorylation of Akt were detected by western blot. Results: Lower plasma H₂S level in CHD patients was predictor of an increased PP, LVMI and IMT. Patients with lower H₂S had a lower survival at the end of the study. H₂S was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. CHD patients with lower H₂S showed an increase of cPKCβII activation, but phosphorylation of Akt decreased. The level of VCAM-1 and ICAM-1 increased significantly. Conclusions: Lower plasma H₂S in CHD patients is associated with cardiovascular risk factors and mortality, which may be mediated by the cPKCβII/Akt pathway and further VCAM-1/ICAM-1 upregulation.

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“…Endothelial damage is the first step in the development of a vascular disease, such as atherosclerosis [22]. Endothelial cells may undergo vesiculation, leading to the release of EMPs into the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

Post-Dilution High Convective Transport Improves Microinflammation and Endothelial Dysfunction Independently of the Technique

Ariza

Merino²,

Carracedo³

et al. 2013

Blood Purif

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Background/Aims: We examined the effects of different online hemodiafiltration techniques on microinflammation and endothelial damage/repair. Methods: The study was designed as a prospective crossover study. Flow cytometry was used to measure CD14⁺CD16⁺ monocytes, apoptotic endothelial microparticles (EMPs), and endothelial progenitor cells (EPCs). Results: Patients treated with high-flux hemodialysis showed a marked chronic inflammatory state (HF-HD 11 ± 2) versus healthy subjects (HS 3.9 ± 2.3; p < 0.05). High convective transport, independent of the technique used, improves microinflammatory parameters (OL-HDF 7.3 ± 2.1 or MID 6.5 ± 3.4; p < 0.05) and the endothelial damage/repair balance compared to HF-HD (EPCs HF-HD 0.3 ± 0.2), with no differences found between the two modalities (EPCs OL-HDF 0.6 ± 0.1, MID 0.6 ± 0.2; p < 0.05). Conclusion: An increase in convective transport improves the microinflammatory state and the endothelial damage/repair of these patients independently of the technique used.

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Accelerated atherosclerosis in haemodialysis patients; correlation of endothelial function with oxidative DNA damage

Cited by 31 publications

References 28 publications

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Oxidative Dna Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Post-Dilution High Convective Transport Improves Microinflammation and Endothelial Dysfunction Independently of the Technique

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