Accelerated angiogenesis by continuous medium flow with vascular endothelial growth factor inside tissue-engineered trachea☆

Tan, Qiang; Steiner, Rudolf; Yang, Lin; Welti, Manfred; Neuenschwander, Peter; Hillinger, Sven; Weder, Walter

doi:10.1016/j.ejcts.2007.01.045

Cited by 44 publications

(29 citation statements)

References 25 publications

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“…64 The engineered autologous cell sheets can not only be used in clinical settings, but they can also be transferred to implant surfaces as epithelium for tissue replacement. 65 However, a major disadvantage of the cell sheet methodology is the time-consuming procedure to create a robust structure for transplantation and the difficulties in handling the sheets.…”

Section: Epithelium In Clinical Tissue-engineering Applicationsmentioning

confidence: 99%

Engineering Functional Epithelium for Regenerative Medicine and In Vitro Organ Models: A Review

Vrana

Lavalle²,

Dokmeci³

et al. 2013

Tissue Engineering Part B: Reviews

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Recent advances in the fields of microfabrication, biomaterials, and tissue engineering have provided new opportunities for developing biomimetic and functional tissues with potential applications in disease modeling, drug discovery, and replacing damaged tissues. An intact epithelium plays an indispensable role in the functionality of several organs such as the trachea, esophagus, and cornea. Furthermore, the integrity of the epithelial barrier and its degree of differentiation would define the level of success in tissue engineering of other organs such as the bladder and the skin. In this review, we focus on the challenges and requirements associated with engineering of epithelial layers in different tissues. Functional epithelial layers can be achieved by methods such as cell sheets, cell homing, and in situ epithelialization. However, for organs composed of several tissues, other important factors such as (1) in vivo epithelial cell migration, (2) multicell-type differentiation within the epithelium, and (3) epithelial cell interactions with the underlying mesenchymal cells should also be considered. Recent successful clinical trials in tissue engineering of the trachea have highlighted the importance of a functional epithelium for long-term success and survival of tissue replacements. Hence, using the trachea as a model tissue in clinical use, we describe the optimal structure of an artificial epithelium as well as challenges of obtaining a fully functional epithelium in macroscale. One of the possible remedies to address such challenges is the use of bottom-up fabrication methods to obtain a functional epithelium. Modular approaches for the generation of functional epithelial layers are reviewed and other emerging applications of microscale epithelial tissue models for studying epithelial/mesenchymal interactions in healthy and diseased (e.g., cancer) tissues are described. These models can elucidate the epithelial/mesenchymal tissue interactions at the microscale and provide the necessary tools for the next generation of multicellular engineered tissues and organ-on-a-chip systems.

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Section: Epithelium In Clinical Tissue-engineering Applicationsmentioning

confidence: 99%

Engineering Functional Epithelium for Regenerative Medicine and In Vitro Organ Models: A Review

Vrana

Lavalle²,

Dokmeci³

et al. 2013

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

show abstract

“…If successful, such bioreactors are believed to clear the way for the generation of clinically applicable, tissue engineered constructs tailored with respect to the required size and shape in vitro. In various fields of hollow organ tissue engineering, such as of the cardiovascular system (Song et al, 2011;Iyer et al, 2011), as well as the respiratory (Tan et al, 2007) and genitourinary tract (Wei et al, 2011) the rapidly growing know-how on bioreactor design and manufacturing has ultimately enhanced their more and more frequent use. The increasing application of these devices has not yet been parallelled in gastrointestinal tissue engineering.…”

Section: Bioreactorsmentioning

confidence: 99%

Bioengineering of Colo-Rectal Tissue

Inglin¹,

Brügger²,

Candinas³

et al. 2011

Tissue Engineering for Tissue and Organ Regeneration

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“…The continuous perfusion of the tubular biodegradable scaffolds coincided with an adequate epithelialization of the constructs and an accelerated vascularization in the chorioallantois membrane assay. The authors assumed that the concept of the in vivo bioreactor allows a more physiological process in the reconstruction of tissues and that better initial conditions are granted for the problem so far not solved, the vascularization of tracheal scaffolds [106] .…”

Section: Vascular Supply Of Tracheal Constructsmentioning

confidence: 99%

Regenerative Medicine: Reconstruction of Tracheal and Pharyngeal Mucosal Defects in Head and Neck Surgery

Rickert

Hiebl

Fuhrmann

et al. 2011

Handbook of Biodegradable Polymers

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Accelerated angiogenesis by continuous medium flow with vascular endothelial growth factor inside tissue-engineered trachea☆

Cited by 44 publications

References 25 publications

Engineering Functional Epithelium for Regenerative Medicine and In Vitro Organ Models: A Review

Engineering Functional Epithelium for Regenerative Medicine and In Vitro Organ Models: A Review

Bioengineering of Colo-Rectal Tissue

Regenerative Medicine: Reconstruction of Tracheal and Pharyngeal Mucosal Defects in Head and Neck Surgery

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