Accelerated ageing and hydrolytic stabilization of poly(lactic acid) (PLA) under humidity and temperature conditioning

Porfyris, Athanasios; Vasilakos, Sozon; Zotiadis, Christos; Papaspyrides, Constantine; Moser, Kevin; Schueren, Lien Van der; Buyle, Guy; Pavlidou, S.; Vouyiouka, Stamatina

doi:10.1016/j.polymertesting.2018.04.018

Cited by 78 publications

(63 citation statements)

References 39 publications

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“…11. This observation supports the idea that change in water uptake at saturation is directly linked to change of hydrophilicity in the TPU [31]. Ester hydrolysis products, carboxylic acid and alcohol, are more hydrophilic, causing an increase in solubility with immersion time.…”

Section: Model Developmentsupporting

confidence: 85%

Hydrolytic kinetic model predicting embrittlement in thermoplastic elastomers

Bardin

Gac

Cérantola

et al. 2020

Polymer Degradation and Stability

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A hydrolytic kinetic model predicting chains scissions of a polyurethane elastomer (TPU) containing an anti-hydrolysis agent (stabilization via carbodiimide) was developed. This model is based on four components: uncatalysed hydrolysis, acid-catalysed hydrolysis, carboxylic acid dissociation and competitive carbodiimide-based deactivation of acid. Protons were considered as the key catalyst responsible for the hydrolysis. Model parameters were determined by fitting experimental data measured on unstabilized and stabilized TPUs, aged in immersion from 40 to 90 C. Scission kinetics were predicted for immersion and 50% relative humidity conditions, from 10 to 100 C. Structure-failure property relationships were also investigated, between molar mass and elongation at break. A master curve was established for elongation at break with molar mass, including both TPUs at four ageing temperatures. By combining predictions for scission kinetics with the molar mass-elongation at break master curve and an embrittlement molar mass as the end-of-life criterion, non-Arrhenian lifetime predictions are proposed for all exposure conditions considered.

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Section: Model Developmentsupporting

confidence: 85%

Hydrolytic kinetic model predicting embrittlement in thermoplastic elastomers

Bardin

Gac

Cérantola

et al. 2020

Polymer Degradation and Stability

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“…The neat PLA membrane showed low water uptake due to hydrophobic methyl groups in its structure. The limited water uptake shown by bare PLA could be initiated in the amorphous regions of PLA, since it is less organized and more accessible to water molecules 60. Corroborating evidence from other studies on PVA-clay nanocomposites for wound dressing applications showed a relatively similar trend as observed in the current research 61.…”

Section: Discussionsupporting

confidence: 86%

<p>CTGF Loaded Electrospun Dual Porous Core-Shell Membrane For Diabetic Wound Healing</p>

Augustine

Zahid

Wang

et al. 2019

IJN

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PurposeImpairment of wound healing is a major issue in type-2 diabetes that often causes chronic infections, eventually leading to limb and/or organ amputation. Connective tissue growth factor (CTGF) is a signaling molecule with several roles in tissue repair and regeneration including promoting cell adhesion, cell migration, cell proliferation and angiogenesis. Incorporation of CTGF in a biodegradable core-shell fiber to facilitate its sustained release is a novel approach to promote angiogenesis, cell migration and facilitate wound healing. In this paper, we report the development of CTGF encapsulated electrospun dual porous PLA-PVA core-shell fiber based membranes for diabetic wound healing applications.MethodsThe membranes were fabricated by a core-shell electrospinning technique. CTGF was entrapped within the PVA core which was coated by a thin layer of PLA. The developed membranes were characterized by techniques such as Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD) analysis. In vitro cell culture studies using fibroblasts, keratinocytes and endothelial cells were performed to understand the effect of CTGF loaded membranes on cell proliferation, cell viability and cell migration. A chicken chorioallantoic membrane (CAM) assay was performed to determine the angiogenic potential of the membranes.ResultsResults showed that the developed membranes were highly porous in morphology with secondary pore formation on the surface of individual fibers. In vitro cell culture studies demonstrated that CTGF loaded core-shell membranes improved cell viability, cell proliferation and cell migration. A sustained release of CTGF from the core-shell fibers was observed for an extended time period. Moreover, the CAM assay showed that core-shell membranes incorporated with CTGF can enhance angiogenesis.ConclusionOwing to the excellent cell proliferation, migration and angiogenic potential of CTGF loaded core-shell PLA-PVA fibrous membranes, they can be used as an excellent wound dressing membrane for treating diabetic wounds and other chronic ulcers.

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“…Even though PLA is mostly used for short-lifespan applications such as food packages or drinking cups, it is becoming increasingly popular in the automotive, electronic or fiber industries where reliability is prioritized [13]. Therefore, the knowledge of ageing behavior is crucial to fully benefit from the polylactide’s utilization.…”

Section: Introductionmentioning

confidence: 99%

“…During the latter process, water diffuses into the polymeric matrix and causes a cleavage reaction of the polymeric chains. The polar, water-soluble low molecular weight products of the hydrolysis further promote the degradation of PLA due to the presence of carboxylic end groups [13,14]. There are numerous factors which influence the process of hydrolytic degradation of PLA.…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous factors which influence the process of hydrolytic degradation of PLA. External factors such as temperature or the aqueous medium’s pH can be distinguished from the internal ones, including the polymer’s crystallinity [13,14] or the presence of modifying agents. It is generally accepted that the first stage of hydrolysis takes place in the amorphous regions of the polymer, where the diffusion of water is possible.…”

Section: Introductionmentioning

confidence: 99%

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Accelerated Weathering of Polylactide-Based Composites Filled with Linseed Cake: The Influence of Time and Oil Content within the Filler

et al. 2019

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This paper presents the effects of accelerated weathering on the properties of polylactide (PLA) composites filled with linseed cake. The particle-shaped waste filler with different linseed oil content (0.9–39.8 wt %) was incorporated with constant amount of 10 wt % to a polymeric matrix and subjected to accelerated weathering tests with different exposition times. The structure of the composites, their mechanical, thermal, and thermo-mechanical properties were evaluated by means of scanning electron microscopy, tensile test, dynamic mechanical thermal analysis, and differential scanning calorimetry prior to and after weathering. The results of the measurements were analyzed in reference to the amount of crude oil contained in the filler. The behavior of the multiphase composite during weathering was described. It was found that the oil-rich samples during the first stage of the process showed increased resistance to hydrolytic degradation due to their relatively high crystallinity. The presence of water and elevated temperatures caused swelling of the filler and cracking of the polymeric matrix. Those discontinuities enabled the plasticizing oil to be rinsed out of the composite and thus water penetrated into the samples. As a result, the PLA-based composites containing oil-rich linseed cake were found to be more vulnerable to hydrolytic degradation in a longer time.

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Accelerated ageing and hydrolytic stabilization of poly(lactic acid) (PLA) under humidity and temperature conditioning

Cited by 78 publications

References 39 publications

Hydrolytic kinetic model predicting embrittlement in thermoplastic elastomers

Hydrolytic kinetic model predicting embrittlement in thermoplastic elastomers

<p>CTGF Loaded Electrospun Dual Porous Core-Shell Membrane For Diabetic Wound Healing</p>

Accelerated Weathering of Polylactide-Based Composites Filled with Linseed Cake: The Influence of Time and Oil Content within the Filler

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