Accelerated 15 mW pulsed-light crosslinking to treat progressive keratoconus: Two-year clinical results

Mazzotta, Cosimo; Baiocchi, Stefano; Bagaglia, Simone Alex; Fruschelli, Mario; Meduri, Alessandro; Rechichi, Miguel

doi:10.1016/j.jcrs.2017.05.030

Cited by 50 publications

(39 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the progressive nature of myopia in most of these patients, the efficacy of the procedure decreases with time [15]. Corneal diseases such as keratoconus or development of cataracts may also induce progression of myopia [16]. However preoperative corneal topography was normal in all eyes and cataracts did not developed in any eye.…”

Section: Discussionmentioning

confidence: 99%

Rotational Stability of a New Posterior Chamber Toric Phakic Intraocular Lens

Yaşa

Köse²,

Ağca

2020

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. To evaluate the refractive results and rotational stability of Eyecryl toric phakic intraocular lens (pIOL). Methods. In this retrospective single-surgeon case series, manifest refraction, visual acuities, endothelial cell density (ECD), and pIOL rotation were evaluated over 6 months. Results. 43 eyes from 23 patients were included. At 6 months, the SE was within ±0.50 D of emmetropia in 30 (70%) eyes and within ±1.00 D of emmetropia in 39 (91%) eyes. The efficacy and safety indices were 1.25 ± 0.38 and 1.41 ± 0.34, respectively. Mean ECD was 2719 ± 296 cells/mm2 at the preoperative visit and 2779.42 ± 422 cells/mm2 at the 6-month visit (p>0.05). The mean value of absolute axis orientation error was 4.95 ± 5.28°. Mean absolute change in axis orientation between visits was less than 3° for all visit intervals. Ninety percent or more of lenses were found to rotate 5° or less between all visit intervals. None of the patients experienced a vision-threatening complication, and no patient required secondary IOL repositioning. Conclusion. The pIOL appears to effectively reduce subjective manifest astigmatism and provide good visual acuity. Its position was found to be stable throughout the follow-up.

show abstract

Section: Discussionmentioning

confidence: 99%

Rotational Stability of a New Posterior Chamber Toric Phakic Intraocular Lens

Yaşa

Köse²,

Ağca

2020

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Moreover, the 9mW/cm 2 A-CXL was safe for corneal endothelium, stabilizing the progression of keratoconus and iatrogenic ectasia with a significant reduction in topographic keratometry values and a significant increase in CDVA, comparable with conventional 3mW/cm 2 CXL in a mid-term (two-years) follow-up. 63 Mazzotta et al 73 documented the clinical and microstructural IVCM and OCT results of accelerated 15mW/cm 2 pulsed-light corneal crosslinking (CXL) in progressive KC showing a distinct DL at 280 ±30 µm depth on average. The 15mW/cm 2 pulsed-light epithelium-off A-CXL confirmed the laboratory data of Krueger et al 72 demonstrating the safety and the clinical efficacy of this protocol in stabilizing KC progression through 2 years of follow-up.…”

Section: -Dmentioning

confidence: 99%

The meaning of the demarcation line after riboflavin-UVA corneal collagen crosslinking

Mazzotta

Wollensak

Raiskup³

et al. 2019

Expert Review of Ophthalmology

Self Cite

View full text Add to dashboard Cite

Since at least two decades, corneal cross-linking by riboflavin and UV-A irradiation stands as an established treatment option of progressive corneal ectasia. More than ten years ago, the histological evaluation of animal corneas and later of human corneas by means of in vivo biomicroscopy and scanning laser confocal microscopy demonstrated in corneas treated with cross-linking procedure the occurrence of a demarcation line running almost parallel to the corneal surface. The feature is a direct consequence of the cross-linking-induced photooxidative modification of the stromal tissue due to riboflavin stromal concentration, light distribution within the corneal stroma, riboflavin activation, oxygen availability and diffusion in the corneal stroma, radicals release, and UV-A exposure time. In this study, the general role of the demarcation line observed after a corneal cross-linking process, in particular its mechanical relevance, clinical consequences, and other various findings in the numerous nowadays available modalities of this treatment, are reviewed objectively.

show abstract

“…Because the Dresden protocol requires a long treatment time of 60 minutes, accelerated protocols have been proposed to shorten the treatment time [103][104][105][106]. Recent studies include evaluations of pulsed or fractionated UV-A protocols in order to improve the effectiveness of accelerated protocols 107. Current treatment protocols require either the removal of the epithelium or exposure of the intact epithelium to agents that increase the permeability of the cell layer, followed by the application of topical riboflavin and UV-A treatment.…”

mentioning

confidence: 99%